Cited by 18Circadian rhythm and melatoninDietary Effects on HealthSleep and Work-Related Fatigue

The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.

Metabolism as an integral cog in the mammalian circadian clockwork

Open access

Gamble, Karen L., Young, Martin E.·2013·Critical Reviews in Biochemistry and Molecular Biology

DOI 10.3109/10409238.2013.786672PMC PMC3862897

Open this paper in CoChat — free account

Abstract

Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g. DNA synthesis) to the whole organism (e.g. behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell-autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell-autonomous circadian clocks and metabolism and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3109/10409238.2013.786672

Cites

208 of 208 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index
Taheri, S., Lin, L., Austin, D., Young, T., & Mignot, E. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010062 · Cited by 2,477 · cited 1×
“The satiety hormone leptin is an attractive candidate to explain this relationship between sleep and metabolism because peak leptin levels normally reached during the night are blunted in a dosedependent manner to the amount of sleep restriction (Taheri et al., 2004).”
Background
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Quantity and Quality of Sleep and Incidence of Type 2 Diabetes
Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010) · Diabetes Care · doi:10.2337/dc09-1124 · Cited by 1,670
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426
The metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365
Molecular cloning and expression of glycogen synthase kinase‐3/factor A.
Woodgett, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07419.x · Cited by 1,362
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216
Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis
Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059
Physiological significance of a peripheral tissue circadian clock
Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958
Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932
Slow-wave sleep and the risk of type 2 diabetes in humans
Tasali, E., Leproult, R., Ehrmann, D. A., & Van Cauter, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706446105 · Cited by 921
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 910
The Meter of Metabolism
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 1×
“Similar to humans, rodents exhibit marked diurnal variations in metabolic parameters, at the whole body, organ and cellular levels (Green et al., 2008; Rutter et al., 2002; Wijnen & Young, 2006).”
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857
Circadian clocks in human red blood cells
O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 843
GSK3 signalling in neural development
Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 841
A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms
Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Vollmers, C., Gill, S., DiTacchio, L., Pulivarthy, S. R., Le, H. D., & Panda, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909591106 · Cited by 765
Circadian Rhythms in Man: A self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity
Aschoff, J. (1965) · Science · doi:10.1126/science.148.3676.1427 · Cited by 752
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
Frame, S., Cohen, P., & Biondi, R. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00253-2 · Cited by 724
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Hassa, P. O., Haenni, S. S., Elser, M., & Hottiger, M. O. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-05 · Cited by 719
Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
Yin, L., Wu, N., Curtin, J. C., Qatanani, M., Szwergold, N. R., Reid, R. A., Waitt, G. M., Parks, D. J., Pearce, K. H., Wisely, G. B., et al. (2007) · Science · doi:10.1126/science.1150179 · Cited by 707
Putative contributors to the secular increase in obesity: exploring the roads less traveled
Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D., Pietrobelli, A., Barger, J. L., Fontaine, K. R., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803326 · Cited by 659
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 632
INFLUENCE OF CIRCADIAN TIME OF HYPERTENSION TREATMENT ON CARDIOVASCULAR RISK: RESULTS OF THE MAPEC STUDY
Hermida, R. C., Ayala, D. E., Mojón, A., & Fernández, J. R. (2010) · Chronobiology International · doi:10.3109/07420528.2010.510230 · Cited by 608
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567
The human circadian metabolome
Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566
Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis
Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536
Sleep Apnea and Heart Failure
Bradley, T. D., & Floras, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000061758.05044.64 · Cited by 522
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 512
Self-citation
Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study.
Chaput, J., Després, J., Bouchard, C., & Tremblay, A. (2007) · Obesity · doi:10.1038/oby.2007.512 · Cited by 498
Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects
Ravussin, É. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.3.566 · Cited by 482
Linking neural activity and molecular oscillations in the SCN
Colwell, C. S. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3086 · Cited by 474
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465
Increased risk of ischaemic heart disease in shift workers
Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBPPreprint
Ripperger, J. A., Shearman, L. P., Reppert, S. M., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.14.6.679 · Cited by 429
Clinical Relevance of Nighttime Blood Pressure and of Daytime Blood Pressure Variability
Palatini, P. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400210081013 · Cited by 424
Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanismPreprint
Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) · Genes & Development · doi:10.1101/gad.873501 · Cited by 412
Metabolism and the Control of Circadian Rhythms
Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 405
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373
The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse
Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367
Diurnal Variations of Blood Pressure and Microalbuminuria in Essential Hypertension
Bianchi, S., Bigazzi, R., Baldari, G., Sgherri, G., & Campese, V. M. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.1.23 · Cited by 366
Suprachiasmatic Nucleus: Use of 14 C-Labeled Deoxyglucose Uptake as a Functional Marker
Schwartz, W. J., & Gainer, H. (1977) · Science · doi:10.1126/science.887940 · Cited by 358 · cited 1×
“…utilization (uptake of 2-deoxyglucose) within the suprachiasmatic nucleus (SCN) of animals were observed, independent of the lighting conditions (Schwartz & Gainer, 1977); and 20 years later, these rhythms were shown to persist at the single cell level in immortalized rat SCN cells (Earnest et…”
Background
Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
Kaasik, K., & Lee, C. C. (2004) · Nature · doi:10.1038/nature02724 · Cited by 352
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351
The Clocks That Time Us: Physiology of the Circadian Timing System
(1983) · Journal of Gerontology · doi:10.1093/geronj/38.2.246a · Cited by 349
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 347
Interplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 341
Self-citation
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340
A Daily Rhythm in Glucose Tolerance
la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337
Circadian Clock Control by SUMOylation of BMAL1
Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J., & Sassone‐Corsi, P. (2005) · Science · doi:10.1126/science.1110689 · Cited by 329
Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323
Neurons and networks in daily rhythms
Herzog, E. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2215 · Cited by 321
Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans
Jung, C. M., Melanson, E. L., Frydendall, E. J., Perreault, L., Eckel, R. H., & Wright, K. P. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.197517 · Cited by 318
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters
Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317
Incidence of metabolic syndrome among night-shift healthcare workers
Pietroiusti, A., Neri, A., Somma, G., Coppeta, L., Iavicoli, I., BERGAMASCHI, A., & Magrini, A. (2009) · Occupational and Environmental Medicine · doi:10.1136/oem.2009.046797 · Cited by 310
Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ
Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308
Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila
Xu, K., Zheng, X., & Sehgal, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.006 · Cited by 306
The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels
Kalsbeek, A., Fliers, E., Romijn, J. A., la Fleur, S. E., Wortel, J., Bakker, O., Endert, E., & Buijs, R. M. (2001) · Endocrinology · doi:10.1210/endo.142.6.8197 · Cited by 305
Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation
Bodosi, B., Gardi, J., Hajdu, I., Szentirmai, É., Obál, F., & Krueger, J. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00294.2004 · Cited by 305
Glycogen Synthase Kinase 3α-Specific Regulation of Murine Hepatic Glycogen Metabolism
MacAulay, K., Doble, B. W., Patel, S., Hansotia, T., Sinclair, E. M., Drucker, D. J., Nagy, A., & Woodgett, J. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.013 · Cited by 303
Deleterious effects of omitting breakfast on insulin sensitivity and fasting lipid profiles in healthy lean women1–3
Farshchi, H. R., Taylor, M. A., & Macdonald, I. A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.388 · Cited by 302
Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation
Sahar, S., Zocchi, L., Kinoshita, C., Borrelli, E., & Sassone‐Corsi, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008561 · Cited by 293
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 289
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β
Hirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., & Kay, S. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811410106 · Cited by 285
Glycogen Synthase Kinase-3 - An Overview of An Over-Achieving Protein Kinase
Kockeritz, L. K., Doble, B. W., Patel, S., & Woodgett, J. R. (2006) · Current Drug Targets · doi:10.2174/1389450110607011377 · Cited by 285
The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease
Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277
Self-citation
Nucleocytoplasmic shuttling and mCRY‐dependent inhibition of ubiquitylation of the mPER2 clock protein
Yagita, K., Tamanini, F., Yasuda, M., Hoeijmakers, J. H. J., van der Horst, G. T. J., & Okamura, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.6.1301 · Cited by 273
Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262
A Suprachiasmatic Nucleus Generated Rhythm In Basal Glucose Concentrations
Fleur, L., Kalsbeek, Wortel, & Buijs (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00373.x · Cited by 256
The rhythm of rest and excess
Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 255
Short Communication: Ischemia/Reperfusion Tolerance Is Time-of-Day–Dependent: Mediation by the Cardiomyocyte Circadian Clock
Durgan, D. J., Pulinilkunnil, T., Villegas-Montoya, C., Garvey, M. E., Frangogiannis, N. G., Michael, L. H., Chow, C.-W., Dyck, J. R. B., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209346 · Cited by 254
Self-citation
Clock Genes in the Heart
Young, M. E., Razeghi, P., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh1101.091190 · Cited by 252
Self-citation
Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity
Coomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., van Dijk, K. W., Biermasz, N. R., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-210898 · Cited by 252
Activation of 5′-AMP-activated Kinase with Diabetes Drug Metformin Induces Casein Kinase Iɛ (CKIɛ)-dependent Degradation of Clock Protein mPer2
Um, J. H., Yang, S., Yamazaki, S., Kang, H., Viollet, B., Foretz, M., & Chung, J. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700070200 · Cited by 244
Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men.
Degaute, J. P., van de Borne, P., Linkowski, P., & Van Cauter, E. (1991) · Hypertension · doi:10.1161/01.hyp.18.2.199 · Cited by 243
Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm
Van Cauter, E., Shapiro, E. T., Tillil, H., & Polonsky, K. S. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.4.e467 · Cited by 240
Evidence for a Circadian Rhythm of Insulin Sensitivity in Patients With NIDDM Caused by Cyclic Changes in Hepatic Glucose Production
Boden, G., Chen, X., & Urbain, J. L. (1996) · Diabetes · doi:10.2337/diab.45.8.1044 · Cited by 228 · cited 2×
“Although insulin sensitivity is relatively low during the night in healthy people, subjects with diabetes show increased sensitivity to insulin at this phase (Boden et al., 1996).”
Background
Clock is important for food and circadian regulation of macronutrient absorption in mice
Pan, X., & Hussain, M. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900085-jlr200 · Cited by 226
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
Wang, T. A., Yu, Y. V., Govindaiah, G., Ye, X., Artinian, L. R., Coleman, T. P., Sweedler, J. V., Cox, C. L., & Gillette, M. U. (2012) · Science · doi:10.1126/science.1222826 · Cited by 221
Work characteristics and incidence of type 2 diabetes in women.
Kroenke, C. H., Spiegelman, D., Manson, J., Schernhammer, E. S., Colditz, G. A., & Kawachi, I. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj355 · Cited by 220
The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function
Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00582.2005 · Cited by 218
Self-citation
Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake
Nagai, K., Nishio, T., Nakagawa, H., Nakamura, S., & Fukuda, Y. (1978) · Brain Research · doi:10.1016/0006-8993(78)90648-0 · Cited by 217
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215
Working on atypical schedules
Boivin, D. B., Tremblay, G. M., & James, F. O. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.015 · Cited by 214
High-fat feeding alters the clock synchronization to light
Mendoza, J., Pévet, P., & Challet, E. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.159566 · Cited by 213
Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice
Bray, M. S., Ratcliffe, W. F., Grenett, M. H., Brewer, R. A., Gamble, K. L., & Young, M. E. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.137 · Cited by 213
Self-citation
Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207
Postprandial hormone and metabolic responses amongst shift workers in Antarctica
Lund, J., Arendt, J., Hampton, S., English, J., & Morgan, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710557 · Cited by 206
Sleep-Promoting Effects of Melatonin: At What Dose, in Whom, Under What Conditions, and by What Mechanisms?
Sack, R. L., Hughes, R. J., Edgar, D. M., & Lewy, A. J. (1997) · SLEEP · doi:10.1093/sleep/20.10.908 · Cited by 205
Circadian Adaptation to Night-Shift Work by Judicious Light and Darkness Exposure
Boivin, D. B., & James, F. O. (2002) · Journal of Biological Rhythms · doi:10.1177/0748730402238238 · Cited by 205
Altered sleep regulation in leptin-deficient mice
Laposky, A. D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., & Turek, F. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2005 · Cited by 203
The clocks that time us. Physiology of the circadian timing system
Aschoff, J. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90088-3 · Cited by 200
High-fat diet acutely affects circadian organisation and eating behavior
Pendergast, J. S., Branecky, K. L., Yang, W., Ellacott, K. L. J., Niswender, K. D., & Yamazaki, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12133 · Cited by 198
Shift Work in Nurses: Contribution of Phenotypes and Genotypes to Adaptation
Gamble, K. L., Motsinger‐Reif, A. A., Hida, A., Borsetti, H., Servick, S. V., Ciarleglio, C. M., Robbins, S., Hicks, J., Carver, K., Hamilton, N. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018395 · Cited by 194
Self-citation
The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191
7 Indirect calorimetry
Jéquier, E., & Felber, J.-P. (1987) · Baillière's Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(87)80011-3 · Cited by 191
Health risks related to shift work
Koller, M. (1983) · International Archives of Occupational and Environmental Health · doi:10.1007/bf00406178 · Cited by 191
Activity Feedback to the Mammalian Circadian Pacemaker: Influence on Observed Measures of Rhythm Period Length
Edgar, D. M., Martin, C. E., & Dement, W. C. (1991) · Journal of Biological Rhythms · doi:10.1177/074873049100600301 · Cited by 187
The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Coomans, C. P., van den Berg, S. A. A., Lucassen, E. A., Houben, T., Pronk, A. C. M., van der Spek, R. D., Kalsbeek, A., Biermasz, N. R., Willems van Dijk, K., Romijn, J. A., et al. (2013) · Diabetes · doi:10.2337/db12-0507 · Cited by 173
Lithium Impacts on the Amplitude and Period of the Molecular Circadian Clockwork
Li, J., Lu, W., Beesley, S., Loudon, A. S. I., & Meng, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033292 · Cited by 171
The clock gene, brain and muscle Arnt‐like 1, regulates adipogenesis via Wnt signaling pathway
Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., Minze, L. J., Hsueh, W. A., & Ma, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-205781 · Cited by 168
Alterations of the Circadian Clock in the Heart by Streptozotocin-induced Diabetes
Young, M. E., Wilson, C. R., Razeghi, P., Guthrie, P. H., & Taegtmeyer, H. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1504 · Cited by 167
Self-citation
Impairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice
Ando, H., Kumazaki, M., Motosugi, Y., Ushijima, K., Maekawa, T., Ishikawa, E., & Fujimura, A. (2011) · Endocrinology · doi:10.1210/en.2010-1068 · Cited by 166
Development of dilated cardiomyopathy in Bmal1-deficient mice
Lefta, M., Campbell, K. S., Feng, H.-Z., Jin, J.-P., & Esser, K. A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2012 · Cited by 158
Chronic REM-sleep deprivation of rats elevates metabolic rate and increases UCP1 gene expression in brown adipose tissue
Koban, M., & Swinson, K. L. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00543.2004 · Cited by 152
The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue‐specific expression, but have different target promoter preferences.
Fonjallaz, P., Ossipow, V., Wanner, G., & Schibler, U. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00365.x · Cited by 151
Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1
Sanada, K., Okano, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107850200 · Cited by 151
Diurnal Patterns of Triglycerides, Free Fatty Acids, Blood Sugar, and Insulin during Carbohydrate-Induction in Man and Their Modification by Nocturnal Suppression of Lipolysis
Schlierf, G., & Dorow, E. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107235 · Cited by 148
Alteration of Internal Circadian Phase Relationships after Morning versus Evening Carbohydrate-Rich Meals in Humans
Kräuchi, K., Cajochen, C., Werth, E., & Wirz‐Justice, A. (2002) · Journal of Biological Rhythms · doi:10.1177/074873040201700409 · Cited by 146
Entrainment and phase shifting of circadian rhythms in mice by forced treadmill running
Marchant, E. G., & Mistlberger, R. E. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)80045-x · Cited by 145
O-GlcNAcylation, Novel Post-Translational Modification Linking Myocardial Metabolism and Cardiomyocyte Circadian Clock
Durgan, D. J., Pat, B., Laczy, B., Bradley, J. A., Tsai, J.-Y., Grenett, M. H., Ratcliffe, W. F., Brewer, R. A., Nagendran, J., Villegas‐Montoya, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278903 · Cited by 145
Self-citation
Demonstration of a dawn phenomenon in normal human volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diabetes.33.12.1150 · Cited by 142
Voluntary scheduled exercise alters diurnal rhythms of behaviour, physiology and gene expression in wild‐type and vasoactive intestinal peptide‐deficient mice
Schroeder, A., Truong, D. A., Loh, D. H., Jordan, M. C., Roos, K. P., & Colwell, C. S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.233676 · Cited by 140
DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping
Kurabayashi, N., Hirota, T., Sakai, M., Sanada, K., & Fukada, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01047-09 · Cited by 136
Working for Food Shifts Nocturnal Mouse Activity into the Day
Hut, R. A., Pilorz, V., Boerema, A. S., Strijkstra, A. M., & Daan, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017527 · Cited by 133
CK2α phosphorylates BMAL1 to regulate the mammalian clockPreprint
Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S., Takamatsu, K., & Sassone‐Corsi, P. (2008) · Nature Precedings · doi:10.1038/nsmb.1578 · Cited by 133
Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work
Horowitz, T. S., Cade, B. E., Wolfe, J. M., & Czeisler, C. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e384 · Cited by 133
Biological clocks and the digestive system
Scheving, L. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.9305 · Cited by 130
Direct Regulation of Myocardial Triglyceride Metabolism by the Cardiomyocyte Circadian Clock
Tsai, J.-Y., Kienesberger, P. C., Pulinilkunnil, T., Sailors, M. H., Durgan, D. J., Villegas‐Montoya, C., Jahoor, A., Gonzalez, R., Garvey, M. E., Boland, B. B., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077800 · Cited by 129
Self-citation
Demonstration of a Dawn Phenomenon in Normal Human Volunteers
Bolli, G. B., Feo, P. D., Cosmo, S. D., Perriello, G., Ventura, M. M., Calcinaro, F., Lolli, C., Campbell, P. J., Brunetti, P., & Gerich, J. E. (1984) · Diabetes · doi:10.2337/diab.33.12.1150 · Cited by 129
Immortal Time: Circadian Clock Properties of Rat Suprachiasmatic Cell Lines
Earnest, D. J., Liang, F.-Q., Ratcliff, M., & Cassone, V. M. (1999) · Science · doi:10.1126/science.283.5402.693 · Cited by 129
Circadian Aspects of Postprandial Metabolism
Morgan, L., Hampton, S. M., Gibbs, M. A., & Arendt, J. (2003) · Chronobiology International · doi:10.1081/cbi-120024218 · Cited by 129
Cellular Senescence Impairs Circadian Expression of Clock Genes In Vitro and In Vivo
Kunieda, T., Minamino, T., Katsuno, T., Tateno, K., Nishi, J.-I., Miyauchi, H., Orimo, M., Okada, S., & Komuro, I. (2006) · Circulation Research · doi:10.1161/01.res.0000204504.25798.a8 · Cited by 129
Changes in cortisol secretion during shiftwork: implications for tolerance to shiftwork?
Hennig, J., KIEFERDORF, P., MORITZ, C., Huwe, S., & Netter, P. (1998) · Ergonomics · doi:10.1080/001401398186784 · Cited by 128
Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice
Edgar, D. M., Kilduff, T. S., Martin, C. E., & Dement, W. C. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90080-8 · Cited by 125
Clock gene expression in peripheral leucocytes of patients with type 2 diabetes
Ando, H., Takamura, T., Nagata, N., Shima, K. R., Eto, T., Misu, H., Shiramoto, M., Tsuru, T., Irie, S., Fujimura, A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1194-6 · Cited by 125
Complete or Partial Circadian Re-entrainment Improves Performance, Alertness, and Mood During Night-Shift Work
Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L., & Eastman, C. I. (2004) · SLEEP · doi:10.1093/sleep/27.6.1077 · Cited by 122
Towards the 24-hour society - new approaches for aging shift workers?
Härmä, M., & Ilmarinen, J. (1999) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.488 · Cited by 118
DIURNAL VARIATION IN INSULIN SENSITIVITY
Gibson, T. C., & Jarrett, R. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92472-5 · Cited by 117
Evidence Suggesting that the Cardiomyocyte Circadian Clock Modulates Responsiveness of the Heart to Hypertrophic Stimuli in Mice
Durgan, D. J., Tsai, J.-Y., Grenett, M. H., Pat, B., Ratcliffe, W. F., Villegas‐Montoya, C., Garvey, M. E., Nagendran, J., Dyck, J. R. B., Bray, M. S., et al. (2011) · Chronobiology International · doi:10.3109/07420528.2010.550406 · Cited by 114
Self-citation
Physiologic Versus Pathologic Hypertrophy and the Pressure-Overloaded Myocardium
Weber, K. T., Clark, W. A., Janicki, J. S., et al. (1987) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198700106-00006 · Cited by 113
Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver
Kudo, T., Akiyama, M., Kuriyama, K., Sudo, M., Moriya, T., & Shibata, S. (2004) · Diabetologia · doi:10.1007/s00125-004-1461-0 · Cited by 112
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
Bellet, M. M., Nakahata, Y., Boudjelal, M., Watts, E. F., Mossakowska, D. E., Edwards, K. A., Cervantes, M., Astarita, G., Loh, C., Ellis, J. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214266110 · Cited by 110
Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids
Stavinoha, M. A., RaySpellicy, J. W., Hart-Sailors, M. L., Mersmann, H. J., Bray, M. S., & Young, M. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2004 · Cited by 109
Self-citation
A Compromise Circadian Phase Position for Permanent Night Work Improves Mood, Fatigue, and Performance
Smith, M. R., Fogg, L., & Eastman, C. I. (2009) · SLEEP · doi:10.1093/sleep/32.11.1481 · Cited by 108
Abnormal expressions of circadian-clock and circadian clock-controlled genes in the livers and kidneys of long-term, high-fat-diet-treated mice
Hsieh, M.-C., Yang, S.-C., Tseng, H.-L., Hwang, L.-L., Chen, C.-T., & Shieh, K.-R. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.228 · Cited by 108
The role of cell‐specific circadian clocks in metabolism and disease
Bray, M. S., & Young, M. E. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00684.x · Cited by 106
Self-citation
The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.
Falvey, E., Fleury-Olela, F., & Schibler, U. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00105.x · Cited by 105
Meal frequency patterns determine the phase of mouse peripheral circadian clocks
Kuroda, H., Tahara, Y., Saito, K., Ohnishi, N., Kubo, Y., Seo, Y., Otsuka, M., Fuse, Y., Ohura, Y., Hirao, A., et al. (2012) · Scientific Reports · doi:10.1038/srep00711 · Cited by 105
OBESITY AND HIGH BLOOD PRESSURE OF 12-HOUR NIGHT SHIFT FEMALE CLEAN-ROOM WORKERS
Chen, J., Lin, Y.-C., & Hsiao, S.-T. (2010) · Chronobiology International · doi:10.3109/07420520903502242 · Cited by 105
Obstructive sleep apnea syndrome and hypertension: mechanism of the linkage and 24-h blood pressure control
Kario, K. (2009) · Hypertension Research · doi:10.1038/hr.2009.73 · Cited by 99
Lithium- and Valproate-Induced Alterations in Circadian Locomotor Behavior in Drosophila
Dokucu, M. E., Yu, L., & Taghert, P. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300764 · Cited by 96
Appetite‐regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers
Schiavo‐Cardozo, D., Lima, M. M. O., Pareja, J. C., & Geloneze, B. (2013) · Clinical Endocrinology · doi:10.1111/cen.12114 · Cited by 96
Circadian feeding rhythm after hypothalamic knife-cut isolating suprachiasmatic nucleus
Nishio, T., Shiosaka, S., Nakagawa, H., Sakumoto, T., & Satoh, K. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90172-0 · Cited by 92
Circadian rhythms in disaccharidases of rat small intestine and its relation to food intake
Saito, M., Murakami, E., & Suda, M. (1976) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(76)90181-1 · Cited by 90
Serotonergic afferents mediate activity-dependent entrainment of the mouse circadian clock
Edgar, D. M., Reid, M. S., & Dement, W. C. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.1.r265 · Cited by 90
Altered feeding differentially regulates circadian rhythms and energy metabolism in liver and muscle of rats
Reznick, J., Preston, E., Wilks, D. L., Beale, S. M., Turner, N., & Cooney, G. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.08.010 · Cited by 86 · cited 2×
“Recent studies have shown that this food-induced dyssynchrony extends beyond the central versus peripheral clock relationship, but causes dyssynchrony between peripheral clocks (Bray et al., 2012; Reznick et al., 2013).”
Background
Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats
Koban, M., Le, W. W., & Hoffman, G. E. (2006) · Endocrinology · doi:10.1210/en.2005-0695 · Cited by 85 · cited 1×
“At the CNS level, sleep deprivation also increases hypothalamic expression of neuropeptide y (orexigenic) and decreases expression of proopiomelanocortin (anorectic; Koban et al., 2006).”
Background
Twenty-four-hour melatonin and core body temperature rhythms: their adaptation in night workers
Weibel, L., Spiegel, K., Gronfier, C., FOLLENIUS, M., & BRANDENBERGER, G. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.3.r948 · Cited by 81
Clock genes, intestinal transport and plasma lipid homeostasis
Hussain, M. M., & Pan, X. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.001 · Cited by 80
Essential and expendable features of the circadian timekeeping mechanism
Hardin, P. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.001 · Cited by 77
Clock gene dysfunction in patients with obstructive sleep apnoea syndrome
Burioka, N., Koyanagi, S., Endo, M., Takata, M., Fukuoka, Y., Miyata, M., Takeda, K., Chikumi, H., Ohdo, S., & Shimizu, E. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138207 · Cited by 77
The Nutritional Status and Eating Habits of Shift Workers: A Chronobiological Approach
Pasqua, I. C., & Moreno, C. R. C. (2004) · Chronobiology International · doi:10.1081/cbi-200040310 · Cited by 75
Diurnal Variation in Response to Intravenous Glucose
Whichelow, M. J., Sturge, R. A., KEEN, H., et al. (1974) · BMJ · doi:10.1136/bmj.1.5906.488 · Cited by 75
Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF
Wang, Q., Maillard, M. P., Schibler, U., Burnier, M., & Gachon, F. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00241.2010 · Cited by 70
Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man
Barter, P. J., Carroll, K. F., & Nestel, P. J. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106528 · Cited by 66
Night Shift Performance is Improved by a Compromise Circadian Phase Position: Study 3. Circadian Phase after 7 Night Shifts with an Intervening Weekend Off
Smith, M. R., & Eastman, C. I. (2008) · SLEEP · doi:10.1093/sleep/31.12.1639 · Cited by 64
Heme-Based Sensing by the Mammalian Circadian Protein CLOCK
Lukat-Rodgers, G. S., Correia, C., Botuyan, M. V., Mer, G., & Rodgers, K. R. (2010) · Inorganic Chemistry · doi:10.1021/ic902388q · Cited by 63
Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia–reperfusion
Kung, T. A., Egbejimi, O., Cui, J., Ha, N. P., Durgan, D. J., Essop, M. F., Bray, M. S., Shaw, C. A., Hardin, P. E., Stanley, W. C., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.018 · Cited by 62
Self-citation
Oxygen Consumption and Body Temperatures During the Night
Kreider, M. B., BUSKIRK, E. R., & Bass, D. E. (1958) · Journal of Applied Physiology · doi:10.1152/jappl.1958.12.3.361 · Cited by 61
Circadian and ultradian rhythms in the feeding behaviour and nutrient intakes of oil refinery operators with shift-work every 3--4 days.
Reinberg, A., Migraine, C., Apfelbaum, M., Brigant, L., Ghata, J., Vieux, N., Laporte, A., & Nicolaï (1979) · PubMed · Cited by 61
Circadian rhythms in myocardial metabolism and contractile function: influence of workload and oleate
Durgan, D. J., Moore, M. W., Ha, N. P., Egbejimi, O., Fields, A., Mbawuike, U., Egbejimi, A., Shaw, C. A., Bray, M. S., Nannegari, V., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01361.2006 · Cited by 60
Self-citation
Daily rhythms of glycogen synthetase and phosphorylase activities in rat liver: Influences of food and light
Ishikawa, K., & Shimazu, T. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90119-3 · Cited by 59
Circadian rhythm and sudden death in heart failure
Carson, P. E., O’Connor, C. M., Miller, A. B., Anderson, S., Belkin, R. N., Neuberg, G. W., WERTHEIMER, J. H., Frid, D. J., Cropp, A., & Packer, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00728-2 · Cited by 57
The suprachiasmatic nucleus participates in food entrainment: a lesion study
Castellanos, A., Salgado‐Delgado, R., Rodríguez, K., Buijs, R. M., & Escobar, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.061 · Cited by 57
Unpredictable feeding schedules unmask a system for daily resetting of behavioural and metabolic food entrainment
Escobar, C., Martínez-Merlos, T., Castellanos, A., Miñana-Solis, M. D. C., & Buijs, R. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05893.x · Cited by 56
Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells
Osland, T. M., Fernø, J., Håvik, B., Heuch, I., Ruoff, P., Lærum, O. D., & Steen, V. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379508 · Cited by 56
Protein Kinase G Type II Is Required for Night-to-Day Progression of the Mammalian Circadian Clock
Tischkau, S. A., Mitchell, J. W., Pace, L., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.027 · Cited by 55
In a Rat Model of Night Work, Activity during the Normal Resting Phase Produces Desynchrony in the Hypothalamus
Salgado‐Delgado, R., Saderi, N., Castellanos, A., Buijs, R. M., & Escobar, C. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410383403 · Cited by 51
Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase 3
Paul, J. R., Johnson, R. L., Jope, R. S., & Gamble, K. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.047 · Cited by 51
Self-citation
Circadian Rhythms of Digestive Enzymes in the Small Intestine of the Rat II. Effects of Fasting and Refeeding1
Saito, M., Murakami, E., Nishida, T., et al. (1976) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131312 · Cited by 49
Effect of meal timing on diurnal rhythm of human cholesterol synthesis
Cella, L. K., Cauter, E. V., & Schoeller, D. A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e878 · Cited by 47
Circadian rhythm in sensitivity of glucose metabolism to insulin in rat soleus muscle
Leighton, B., Kowalchuk, J. M., Challiss, R. A. J., & Newsholme, E. A. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.1.e41 · Cited by 43
The metabolism of phospholipids oscillates rhythmically in cultures of fibroblasts and is regulated by the clock protein PERIOD 1
Marquez, S., Crespo, P. M., Carlini, V. P., Garbarino‐Pico, E., Baler, R., Caputto, B. L., & Guido, M. E. (2004) · The FASEB Journal · doi:10.1096/fj.03-0417fje · Cited by 41
Circadian Variation of Insulin Requirement in Insulin Dependent Diabetes Mellitus The Relationship between Circadian Change in Insulin Demand and Diurnal Patterns of Growth Hormone, Cortisol and Glucagon during Euglycemia
Trümper, B., Reschke, K., & Molling, J. (1995) · Hormone and Metabolic Research · doi:10.1055/s-2007-979926 · Cited by 39
Mechanism controlling sleep organization of the obese Zucker rats
Megirian, D., Dmochowski, J., & Farkas, G. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.1.253 · Cited by 37
Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function
Young, M. E. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00473.2009 · Cited by 35
Self-citation
Light responses of the circadian system in leptin deficient mice
Sans-Fuentes, M. A., Dı́ez-Noguera, A., & Cambras, T. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.12.023 · Cited by 35
Diurnal Variations in Cardiovascular Function and Glucose Regulation in Normotensive Humans
Biston, P., Cauter, E. V., Ofek, G., Linkowski, P., Polonsky, K. S., & Degaute, J.-P. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.863 · Cited by 35
Effects of okadaic acid and intracellular Cl- on Na(+)-K(+)-Cl- cotransport
Altamirano, A. A., Breitwieser, G. E., & Russell, J. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.4.c878 · Cited by 34
Restricted wheel access following a light cycle inversion slows re-entrainment without internal desynchrony as measured in Per2Luc mice
Castillo, C., Molyneux, P. C., Carlson, R. H., & Harrington, M. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.003 · Cited by 30
Sleep patterns in the genetically obese Zucker rat: effect of acarbose treatment
Danguir, J. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.1.r281 · Cited by 30
Circadian rhythm of intestinal disaccharidases of rats fed with adiurnal periodicity
Saito, M., Kato, H., & Suda, M. (1980) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1980.238.2.g97 · Cited by 29

Research works printed but not linked: 14

Bray MS, 2012, Int J Obes (Lond)
Danguir J, 1989, Am J Physiol, 256, R281
Edgar DM, 1997, Am J Physiol, 273, R265
Leighton B, 1988, Am J Physiol, 255, E41
Pendergast JS, 2013, Eur J Neurosci
Rau E, 1975, Recent Adv Stud Cardiac Struct Metab, 7, 105
Reinberg A, 1979, Diabete Metab, 5, 33
Saito M, 1980, Am J Physiol, 238, G97
Saito M, 1976, II. Effects of fasting and refeeding. J Biochem, 80, 563
Schiavo-Cardozo D, 2012, Clin Endocrinol (Oxf)
Smith MR, 2008, Circadian phase after 7 night shifts with an intervening weekend off. Sleep, 31, 1639
van Cauter E, 1997, Endocr Rev, 18, 716
van Cauter E, 1992, Am J Physiol, 262, E467
Weibel L, 1997, Am J Physiol, 272, R948

Sorted by citations

Timing of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121
Meal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72
“More precisely, in humans and animals, food intake has been proven to entrain the peripheral clocks of liver, heart, and pancreatic tissue (31 – 33).”
Background

See all 18

Authors: Gamble, K. L., & Young, M. E.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Young, Martin E.
ORCID: Gamble, Karen L.
Young, Martin E.
Venue: Critical Reviews in Biochemistry and Molecular Biology
Publisher: Informa UK Limited
Published: 2013-04-17
Volume: 48
Issue: 4
Pages: 317-331
ISSN: 0045-6411 (ISSN-L)
1040-9238
1549-7798
DOI: 10.3109/10409238.2013.786672
PMC: PMC3862897
OpenAlex: W2007270297
Cited by: 18
References: 208
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 1
FWCI: 0.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000165)
Center for Clinical and Translational Science, University of Alabama at Birmingham
National Heart, Lung, and Blood Institute (HL-074259, HL‑106199, R21HL106199, R21HL107709, HL-107709, R01HL074259)
National Institute of General Medical Sciences (GM086683, R00GM086683, K99GM086683)
National Institute of Neurological Disorders and Stroke (R01NS082413, NS082413)
National Center for Research Resources
National Center for Advancing Translational Sciences
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: circadian clock, metabolic rhythms, metabolism, cardiometabolic disease, sleep-wake cycle, circadian metabolism
MeSH terms: Animals, Circadian Rhythm, Energy Metabolism, Homeostasis, Humans, Mammals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metabolism as an integral cog in the mammalian circadian clockwork

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks