Chronic Physical Health Problems Moderate Changes in Depression and Substance Use Among Dual Diagnosed Individuals During and After Treatment
Open accessAbstract
BACKGROUND: Physical illnesses frequently co-occur with depression and substance use disorders and may impact their improvement. Physical illness symptoms may overlap with or exacerbate somatic symptoms of depression. Individuals may use substances to cope with symptoms of physical illness. OBJECTIVES: We examined whether chronic physical health problems moderated changes in depression and substance use among dual diagnosed individuals during and in the year following treatment. METHODS: Participants were recruited from a Veterans Affairs dual diagnosis outpatient program between March 2000 and November 2007 and were randomized to either Integrated Cognitive-Behavioral Therapy or Twelve-Step Facilitation Therapy. A total of 214 veterans with assessment data for the variables of interest were included in analyses. Participants completed quarterly depression, substance use, and health assessments over an 18 month period. We used linear-mixed effects models to analyze patterns of change for depression and substance use. RESULTS: Individuals with severe chronic health problems and higher intake depression showed slower improvements in both nonsomatic and somatic depression symptoms. Individuals with severe chronic health problems and higher midtreatment substance use showed less improvement in substance use. CONCLUSIONS: Assessing and addressing physical health issues during depression and substance use disorder treatment may improve outcomes.
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Pharmacological treatment of ADHD in adolescents, including with psychostimulant medications, reduces the risk for development of SUD.
“research has shown that pharmacological treatment of ADHD in this population, including with psychostimulant medications, reduces the risk for development of SUD.168”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [168]
The Methods > Participants section describes a VA clinic sample with substance dependence and major depressive disorder (page not available). The Methods > Procedure section mentions psychotropic medications but does not identify ADHD treatment or report whether it reduces later SUD risk. Searches for adolescent ADHD treatment, psychostimulants, and prevention of substance dependence found no passage addressing the claim. (LLM, conf=0.77)
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The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder
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- Authors
- Cui, R., Tate, S. R., Cummins, K., Skidmore, J. R., & Brown, S. A.
- Affiliations
- VA San Diego Healthcare System (US)
- University of California San Diego (US)
- Corresponding author
- Tate, Susan R.
- Venue
- Substance Use & Misuse
- Publisher
- Informa UK Limited
- Published
- 2014-10-07
- Volume
- 50
- Issue
- 2
- Pages
- 174-183
- ISSN
- 1082-6084 (ISSN-L)
- 1532-2491
- PMC
- PMC4374892
- OpenAlex
- W2120071139
- Cited by
- 5
- References
- 56
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Substance Use & Misuse (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (T32AA013525)
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- dual diagnosis, depression, substance use disorders, somatic symptoms of depression, veterans, cognitive behavioral therapy, twelve-step facilitation, treatment outcomes, comorbidities
- MeSH terms
- Adult, Depressive Disorder, Female, Health Status, Humans, Male, Middle Aged, Psychotherapy, Cognitive Behavioral Therapy, Treatment Outcome, Diagnosis, Dual (Psychiatry), Substance-Related Disorders
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