A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers
Open accessAbstract
CONTEXT: Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk. OBJECTIVE: To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers. METHODS: Biomarker levels were compared from 143 smokers, 61 never-smokers and 61 ex-smokers. RESULTS: In total, 27 candidate biomarkers were assessed, 14 were significantly different between smokers and never-smokers (p < 0.01) and of these 14 biomarkers, 12 were able to distinguish between smokers and former smokers (p < 0.05), which indicates the potential for reversibility. CONCLUSIONS: A total of 12 of 27 BOBE are potentially useful tools for future product assessment.
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Simeone, P., Liani, R., Lattanzio, S., Frezza, M., Alfonsetti, M., Cipollone, F., & Santilli, F. (2026) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2026.100782
- Authors
- Haswell, L. E., Papadopoulou, E., Newland, N., Shepperd, C. J., & Lowe, F. J.
- Affiliations
- British American Tobacco (United Kingdom) (GB)
- Corresponding author
- Haswell, Linsey E.
- Venue
- Biomarkers
- Publisher
- Informa UK Limited
- Published
- 2014-05-22
- Volume
- 19
- Issue
- 5
- Pages
- 356-367
- ISSN
- 1354-750X (ISSN-L)
- 1366-5804
- OpenAlex
- W2081043365
- Cited by
- 28
- References
- 71
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Biomarkers (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- tobacco use, smokers, never smokers, former smokers, biomarker discrimination
- MeSH terms
- Adult, Cotinine, Cross-Sectional Studies, Erythrocytes, Female, Humans, Leukocyte Count, Lipoproteins, LDL, Male, Middle Aged, Nicotine, Saliva, Smoking, Dinoprost, Biomarkers, Young Adult
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