Cited by 28Smoking Behavior and CessationCarcinogens and Genotoxicity AssessmentChronic Obstructive Pulmonary Disease (COPD) Research

A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers

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Haswell, Linsey E., Papadopoulou, Ermioni, Newland, Nik, Shepperd, Christopher J., Lowe, Frazer J.·2014·Biomarkers

Abstract

CONTEXT: Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk. OBJECTIVE: To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers. METHODS: Biomarker levels were compared from 143 smokers, 61 never-smokers and 61 ex-smokers. RESULTS: In total, 27 candidate biomarkers were assessed, 14 were significantly different between smokers and never-smokers (p < 0.01) and of these 14 biomarkers, 12 were able to distinguish between smokers and former smokers (p < 0.05), which indicates the potential for reversibility. CONCLUSIONS: A total of 12 of 27 BOBE are potentially useful tools for future product assessment.

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Crossref · 10.3109/1354750x.2014.912354

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Authors
Haswell, L. E., Papadopoulou, E., Newland, N., Shepperd, C. J., & Lowe, F. J.
Affiliations
British American Tobacco (United Kingdom) (GB)
Corresponding author
Haswell, Linsey E.
Venue
Biomarkers
Published
2014-05-22
Volume
19
Issue
5
Pages
356-367
ISSN
  • 1354-750X (ISSN-L)
  • 1366-5804
OpenAlex
W2081043365
Cited by
28
References
71
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 2
FWCI
1.55
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Biomarkers (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
tobacco use, smokers, never smokers, former smokers, biomarker discrimination
MeSH terms
Adult, Cotinine, Cross-Sectional Studies, Erythrocytes, Female, Humans, Leukocyte Count, Lipoproteins, LDL, Male, Middle Aged, Nicotine, Saliva, Smoking, Dinoprost, Biomarkers, Young Adult

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