Cited by 321Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Oxidative stress in vascular disease and its pharmacological prevention

Li, Huige, Horke, Sven, Förstermann, Ulrich·2013·Trends in Pharmacological Sciences

Abstract

Cardiovascular risk factors lead to enhanced production of reactive oxygen species (ROS) generated by NADPH oxidase, xanthine oxidase (XO), the mitochondrial electron-transport chain (ETC), and dysfunctional endothelial nitric oxide synthase (eNOS). When the capacity of antioxidant defense systems [e.g., superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), heme oxygenase (HO), paraoxonase (PON)] is exceeded, this results in oxidative stress, which can promote atherogenesis. Therefore, pharmacological means to prevent oxidative stress are of major therapeutic interest. Some established drugs and novel therapeutic approaches can prevent oxidative stress and, presumably, vascular disease. These include angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 (AT1 receptor) blockers (ARBs), statins, nebivolol, pentaerithrityl tetranitrate (PETN), resveratrol, and mitochondria-targeted antioxidants. Molecular mechanisms involved in the induction of oxidative stress under pathological conditions as well as pharmacological approaches (and their molecular mechanisms) are summarized in this review.

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Crossref · 10.1016/j.tips.2013.03.007

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Authors
Li, H., Horke, S., & Förstermann, U.
Affiliations
University Medical Center of the Johannes Gutenberg University Mainz (DE)
Corresponding author
Förstermann, Ulrich
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2013-06
Volume
34
Issue
6
Pages
313-319
ISSN
0165-6147 (ISSN-L)
OpenAlex
W1994343244
Cited by
321
References
75
Citations by year
2026: 9 · 2025: 13 · 2024: 24 · 2023: 21 · 2022: 26 · 2021: 24 · 2020: 24 · 2019: 25 · 2018: 25 · 2017: 29 · 2016: 23 · 2015: 31 · 2014: 35 · 2013: 11
FWCI
3.67
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
oxidative stress, vascular disease, reactive oxygen species, NADPH oxidase, xanthine oxidase, mitochondrial electron transport chain, endothelial nitric oxide synthase, antioxidant defense, atherogenesis, ACE inhibitors, angiotensin receptor blockers, statins, nebivolol, PETN, resveratrol, mitochondria-targeted antioxidants, cardiovascular risk factors
MeSH terms
Animals, Antioxidants, Humans, Vascular Diseases, Oxidative Stress

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