Mild thyroid hormone excess is associated with a decreased physical function in elderly men
Open accessAbstract
INTRODUCTION: In the adult, subclinical hyperthyroidism (Shyper) may alter skeletal muscle mass and strength. However, whether these effects are present in elderly subjects is not known. We explored the relationship between mild hyperthyroidism and physical function in a population-based sample of older persons. METHODS: In a cross-sectional analysis, calf muscle cross-sectional area (CMA), handgrip strength, nerve conduction velocity (NCV), and Short Physical Performance Battery (SPPB) scores were compared between 364 euthyroid (Eut) and 28 Shyper men as well as between 502 Eut and 39 Shyper women. In a longitudinal analysis, we evaluated the relationship between baseline plasma TSH, FT3 and FT4 and the 3-year change in SPPB score in 304 men and 409 women who were euthyroid at enrolment. RESULTS: At the cross-sectional analysis, Shyper men, but not women, had a significantly (p = 0.02) lower SPPB score than Eut controls, although with comparable CMA, grip strength and NCV, and were more likely to have poor physical performance (odds ratio = 2.97, p < 0.05). Longitudinal analysis showed that in Eut men higher baseline FT4 was significantly (p = 0.02) predictive of a lower SPPB score at the 3-year follow-up. CONCLUSION: Even a modest thyroid hormone excess is associated with a reduced physical function in elderly men.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In older adults, subclinical hyperthyroidism is not associated with low muscle mass and/or strength.
“However, in older adults, subclinical hyperthyroidism was not associated with low muscle mass and/or strength (121–123)”
From Levothyroxine therapy in elderly patients with hypothyroidism (2021) · cites this paper as [122]
Three studies could find no correlation, while the fourth found a correlation between SH and lower physical performance in men only.
“Three could find no correlation, while the fourth found a correlation between SH and lower physical performance in men only (425).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [425]
Four studies have investigated whether SH is associated with self-reported functional capacity or objective measures of physical functioning.
“Four studies have investigated whether SH is associated with self-reported functional capacity or objective measures of physical functioning (420, 423-425).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [425]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Guralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792 · see citing works
Self-citationLauretani, F., Russo, C. R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A. M., Rantanen, T., Guralnik, J. M., & Ferrucci, L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00246.2003 · Cited by 1,946 · see citing works
Self-citationMidlife Hand Grip Strength as a Predictor of Old Age Disability
Rantanen, T. (1999) · JAMA · doi:10.1001/jama.281.6.558 · Cited by 1,481 · see citing works
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418 · see citing works
Thyroid Status, Disability and Cognitive Function, and Survival in Old Age
Gussekloo, J. (2004) · JAMA · doi:10.1001/jama.292.21.2591 · Cited by 899 · see citing works
Ferrucci, L., Bandinelli, S., Benvenuti, E., Iorio, A. D., Macchi, C., Harris, T. B., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03873.x · Cited by 797 · see citing works
Self-citationSarcopenic obesity and inflammation in the InCHIANTI study
Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594 · see citing works
Self-citationThe aging of America. Impact on health care costs
Schneider, E. (1990) · JAMA · doi:10.1001/jama.263.17.2335 · Cited by 591 · see citing works
The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability
Guralnik, J. M., Fried, L. P., Simonsick, E. M., Kasper, J. D., & Lafferty, M. E. (1995) · PsycEXTRA Dataset · doi:10.1037/e306362003-001 · Cited by 504 · see citing works
Self-citationPisani, P. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.suppl_1.s152 · Cited by 473 · see citing works
Grip strength changes over 27 yr in Japanese-American men
Rantanen, T., Masaki, K., Foley, D., Izmirlian, G., White, L. R., & Guralnik, J. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.6.2047 · Cited by 364 · see citing works
Self-citationSubclinical hyperthyroidism and the risk of dementia. The Rotterdam study
Kalmijn, S., Mehta, K. M., Pols, H. A. P., Albert Hofman, D., Drexhage, H. A., & Breteler, M. M. B. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01146.x · Cited by 319 · see citing works
Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Men
van den Beld, A. W., Visser, T. J., Feelders, R. A., Grobbee, D. E., & Lamberts, S. W. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0872 · Cited by 294 · see citing works
Bone-muscle strength indices for the human lower leg
Rittweger, J., Beller, G., Ehrig, J., Jung, C., Koch, U., Ramolla, J., Schmidt, F., Newitt, D., Majumdar, S., Schiessl, H., et al. (2000) · Bone · doi:10.1016/s8756-3282(00)00327-6 · Cited by 270 · see citing works
Association Between Serum Free Thyroxine Concentration and Atrial Fibrillation
Gammage, M. D. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.9.928 · Cited by 225 · see citing works
Boelaert, K., Torlinska, B., Holder, R. L., & Franklyn, J. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2495 · Cited by 196 · see citing works
Ceresini, G., Lauretani, F., Maggio, M. G., Ceda, G. P., Morganti, S., Usberti, E., Chezzi, C., Valcavi, R., Bandinelli, S., Guralnik, J. M., et al. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02080.x · Cited by 185 · see citing works
Self-citationThe aging of America. Impact on health care costs.
Schneider, E. L., & Guralnik, J. M. (1990) · PubMed · Cited by 169 · see citing works
Self-citationHigh-Normal Thyroid Function and Risk of Atrial Fibrillation: The Rotterdam Study
Heeringa, J., Hoogendoorn, E. H., van der Deure, W. M., Hofman, A., Peeters, R. P., Hop, W. C. J., den Heijer, M., Visser, T. J., & Witteman, J. C. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.20.2219 · Cited by 161 · see citing works
The Impact of Overt and Subclinical Hyperthyroidism on Skeletal Muscle
Brennan, M. D., Powell, C., Kaufman, K. R., Sun, P. C., Bahn, R. S., & Nair, K. S. (2006) · Thyroid · doi:10.1089/thy.2006.16.375 · Cited by 155 · see citing works
Measuring muscular strength of the lower limbs by hand-held dynamometer: A standard protocol
Bandinelli, S., Benvenuti, E., Lungo, I. D., Baccini, M., Benvenuti, F., Iorio, A. D., & Ferrucci, L. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03339802 · Cited by 146 · see citing works
Self-citationRl, S. (1996) · PubMed · Cited by 130 · see citing works
Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study.
Valenti, G., Denti, L., Maggio, M., Ceda, G., Volpato, S., Bandinelli, S., Ceresini, G., Cappola, A., Guralnik, J., & Ferrucci, L. (2004) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/59.5.m466 · Cited by 116 · see citing works
Self-citationAxonal degeneration affects muscle density in older men and women
Lauretani, F., Bandinelli, S., Bartali, B., Iorio, A. D., Giacomini, V., Corsi, A. M., Guralnik, J. M., & Ferrucci, L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.009 · Cited by 103 · see citing works
Self-citationAghini-Lombardi, F., Antonangeli, L., Pinchera, A., et al. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.4.3867 · Cited by 92 · see citing works
Bandinelli, S., Lauretani, F., Boscherini, V., Gandi, F., Pozzi, M., Corsi, A. M., Bartali, B., Lova, R. M., Guralnik, J. M., & Ferrucci, L. (2006) · Aging Clinical and Experimental Research · doi:10.1007/bf03324831 · Cited by 91 · see citing works
Self-citationClinical implications of the reduced activity of the GH-IGF-I axis in older men.
Ceda, G. P., Dall’Aglio, E., Maggio, M. G., et al. (2005) · PubMed · Cited by 87 · see citing works
Self-citationMild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany
Lombardi, F. A., Pinchera, A., Antonangeli, L., Rago, T., Chiovato, L., Bargagna, S., Bertucelli, B., Ferretti, G., Sbrana, B., Marcheschi, M., et al. (1995) · Journal of Endocrinological Investigation · doi:10.1007/bf03349700 · Cited by 72 · see citing works
Increased Lipid Peroxidation in Hyperthyroid Patients: Suppression by Propylthiouracil Treatment
Videla, L. A., Sir, T., & Wolff, C. (1988) · Free Radical Research Communications · doi:10.3109/10715768809068553 · Cited by 70 · see citing works
Endocrine Modulators of Necrotic Neuron Death
Chan, R. S., Huey, E. D., Maecker, H. L., Cortopassi, K. M., Howard, S. A., Iyer, A., Mclntosh, L. J., Ajilore, O., Brooke, S. M., & Sapolsky, R. M. (1996) · Brain Pathology · doi:10.1111/j.1750-3639.1996.tb00877.x · Cited by 39 · see citing works
Castaneda‐Sceppa, C., Price, L. L., Noel, S. E., Midle, J. B., Falcón, L. M., & Tucker, K. L. (2010) · Journal of Aging and Health · doi:10.1177/0898264310366738 · Cited by 32 · see citing works
Müssig, K., Leyhe, T., Holzmüller, S., Klein, R., Weinert, C., Saur, R., Klingberg, S., Häring, H., & Gallwitz, B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.011 · Cited by 27 · see citing works
Senovilla, L., Garcı́a-Sancho, J., & Villalobos, C. (2005) · Endocrinology · doi:10.1210/en.2005-0836 · Cited by 21 · see citing works
Kinoshita, K., Kawashima, K., Kawashima, Y., et al. (1996) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.71.139 · Cited by 17 · see citing works
Erythropoietin and polyneuropathy in older persons
Lauretani, F., Bandinelli, S., Strotmeyer, E. S., et al. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.006 · Cited by 6 · see citing works
Self-citationWhite Matter Alteration in a Patient With Graves' Disease
Kurne, A., Aydın, Ö. F., & Karabudak, R. (2007) · Journal of Child Neurology · doi:10.1177/0883073807306250 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938 · see citing works
“Three could find no correlation, while the fourth found a correlation between SH and lower physical performance in men only (425).”
BackgroundClinical aspects of thyroid function during ageing
Chaker, L., Cappola, A. R., Mooijaart, S. P., & Peeters, R. P. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30028-7 · Cited by 94 · see citing works
Self-citationThyroid dysfunction in the elderly
Boelaert, K. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.30 · Cited by 84 · see citing works
Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects
Sheng, Y., Ma, D., Zhou, Q., Wang, L., Sun, M., Wang, S., Qi, H., Liu, J., Ding, G., & Duan, Y. (2019) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1057-z · Cited by 65 · see citing works
Ceresini, G., Ceda, G. P., Lauretani, F., Maggio, M., Usberti, E., Marina, M., Bandinelli, S., Guralnik, J. M., Valenti, G., & Ferrucci, L. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12267 · Cited by 67 · see citing works
Self-citationThyroid Function and Sarcopenia: Results from the ELSA-Brasil Study
Szlejf, C., Suemoto, C. K., Janovsky, C. C. P. S., Barreto, S. M., Diniz, M. D. F. H. S., Lotufo, P. A., & Bensenor, I. M. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16416 · Cited by 60 · see citing works
Levothyroxine therapy in elderly patients with hypothyroidism
Effraimidis, G., Watt, T., & Feldt-Rasmussen, U. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.641560 · Cited by 60 · see citing works
Kong, S. H., Kim, J. H., Park, Y. J., Lee, J. H., Hong, A. R., Shin, C. S., & Cho, N. H. (2020) · Osteoporosis International · doi:10.1007/s00198-019-05137-w · Cited by 28 · see citing works
Park, Y. S., Chang, Y., Lee, Y., Shin, H., Ryu, S., & Yoon, K. J. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.13710 · Cited by 10 · see citing works
- Authors
- Ceresini, G., Ceda, G. P., Lauretani, F., Maggio, M., Bandinelli, S., Guralnik, J. M., Cappola, A. R., Usberti, E., Morganti, S., Valenti, G., & Ferrucci, L.
- Affiliations
- University of Parma (IT)
- Ospedale di Parma (IT)
- Azienda Sanitaria di Firenze (IT)
- National Institute on Aging (US)
- University of Pennsylvania (US)
- Corresponding author
- Ceresini, Graziano
- ORCID
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2011-11-24
- Volume
- 14
- Issue
- 4
- Pages
- 213-219
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- PMC
- PMC4588067
- OpenAlex
- W2121105702
- Cited by
- 41
- References
- 37
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2021: 5 · 2020: 9 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000015)
- National Institute on Minority Health and Health Disparities (263-MD-916413, 263MD 821336)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- subclinical hyperthyroidism, physical function, older men, Short Physical Performance Battery, free thyroxine, free triiodothyronine, thyroid-stimulating hormone, muscle cross-sectional area, grip strength, nerve conduction velocity
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Exercise Test, Female, Humans, Hyperthyroidism, Longitudinal Studies, Male, Neural Conduction, Thyrotropin, Thyroxine, Triiodothyronine, Muscle, Skeletal, Hand Strength, Asymptomatic Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
