CoChat
Sign Up
Cited by 108Hormonal and reproductive studiesBone health and osteoporosis researchMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study

Open access
Aversa, Antonio, Bruzziches, Roberto, Francomano, Davide, Greco, Emanuela A., Fornari, Rachele, Luigi, Luigi Di, Lenzi, Andrea, Migliaccio, Silvia·2012·The Aging Male
DOI 10.3109/13685538.2011.631230
Open this paper in CoChat — free accountOpen PDF

Abstract

We evaluated the effects of long-term testosterone replacement therapy (TRT) on the bone mineral density (BMD) in obese patients with metabolic syndrome (MS) and late-onset hypogonadism (LOH). Sixty men (mean age 57 ± 10) with low serum testosterone (T < 320 ng/dL) and MS regardless the presence of osteoporosis were enrolled. Forty men received intramuscular T-undecanoate (TU) four times/year for 36 months and 20 age-matched hypogonadal men with MS in whom T treatment was contraindicated were used as controls. Hormonal, biochemical markers, vertebral and femoral BMD by dual-energy x-ray absorptiometry were measured. At baseline, overall patients had mild osteopenia (lumbar BMD= 0.891 ± 0.097 g/cm(2); femoral BMD= 0.847 ± 0.117 g/cm(2)). TU induced a significant improvement of bone mass after 36 months (lumbar BMD=1.053 ± 0.145 g/cm(2); p < 0.002; femoral BMD=0.989 ± 0.109; p < 0.003 g/cm(2)) with a 5%/year increase and a significant reduction in hs-CRP without changes in body mass index. A direct relationship between serum T and BMD increments at the lumbar (r(2) = 0.66, p < 0.0001) and femoral (r(2) =0.52, p < 0.0001) sites was demonstrated. Study adherence was 50% without serious side effects. Long-term TRT in middle-aged men with LOH and MS determines a significant increase in both vertebral and femoral BMD related to increased serum T levels, probably independently from estradiol modifications.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3109/13685538.2011.631230

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 52 references

Research works printed but not linked: 5

  1. Reid IR, 1993, Am J Physiol, 265, E655
  2. Vignozzi L, 2010, J Endocrinol Invest, 33, 27
  3. 10.1210/jcem.86.8.7736 · DOI · Paper page
  4. Korach KS, 1996, Recent Prog Horm Res, 51
  5. Snyder PJ, 1999, J Clin Endocrinol Metab, 84, 1966

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Aversa, A., Bruzziches, R., Francomano, D., Greco, E. A., Fornari, R., Luigi, L. D., Lenzi, A., & Migliaccio, S.
Affiliations
  • Sapienza University of Rome (IT)
  • Foro Italico University of Rome (IT)
ORCID
Venue
The Aging Male
Publisher
Informa UK Limited
Published
2012-03-23
Volume
15
Issue
2
Pages
96-102
ISSN
  • 1368-5538 (ISSN-L)
  • 1473-0790
DOI
10.3109/13685538.2011.631230
OpenAlex
W2145291570
Cited by
108
References
52
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 4
FWCI
10.78
Type
journal article
Language
en
Open access
Locations
  • The Aging Male (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone undecanoate, testosterone replacement therapy, bone mineral density, andropause, metabolic syndrome, obesity, osteopenia, middle-aged men, serum testosterone, C-reactive protein, estradiol, medication adherence
MeSH terms
Aged, Androgens, Femur, Humans, Hypogonadism, Male, Middle Aged, Obesity, Spine, Testosterone, Bone Density, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review