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Cited by 108Hormonal and reproductive studiesBone health and osteoporosis researchMenopause: Health Impacts and Treatments

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Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 36 months controlled study

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Aversa, Antonio, Bruzziches, Roberto, Francomano, Davide, Greco, Emanuela A., Fornari, Rachele, Luigi, Luigi Di, Lenzi, Andrea, Migliaccio, Silvia·2012·The Aging Male
DOI 10.3109/13685538.2011.631230
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Abstract

We evaluated the effects of long-term testosterone replacement therapy (TRT) on the bone mineral density (BMD) in obese patients with metabolic syndrome (MS) and late-onset hypogonadism (LOH). Sixty men (mean age 57 ± 10) with low serum testosterone (T < 320 ng/dL) and MS regardless the presence of osteoporosis were enrolled. Forty men received intramuscular T-undecanoate (TU) four times/year for 36 months and 20 age-matched hypogonadal men with MS in whom T treatment was contraindicated were used as controls. Hormonal, biochemical markers, vertebral and femoral BMD by dual-energy x-ray absorptiometry were measured. At baseline, overall patients had mild osteopenia (lumbar BMD= 0.891 ± 0.097 g/cm(2); femoral BMD= 0.847 ± 0.117 g/cm(2)). TU induced a significant improvement of bone mass after 36 months (lumbar BMD=1.053 ± 0.145 g/cm(2); p < 0.002; femoral BMD=0.989 ± 0.109; p < 0.003 g/cm(2)) with a 5%/year increase and a significant reduction in hs-CRP without changes in body mass index. A direct relationship between serum T and BMD increments at the lumbar (r(2) = 0.66, p < 0.0001) and femoral (r(2) =0.52, p < 0.0001) sites was demonstrated. Study adherence was 50% without serious side effects. Long-term TRT in middle-aged men with LOH and MS determines a significant increase in both vertebral and femoral BMD related to increased serum T levels, probably independently from estradiol modifications.

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Research works printed but not linked: 5

  1. Reid IR, 1993, Am J Physiol, 265, E655
  2. Vignozzi L, 2010, J Endocrinol Invest, 33, 27
  3. 10.1210/jcem.86.8.7736 · DOI · Paper page
  4. Korach KS, 1996, Recent Prog Horm Res, 51
  5. Snyder PJ, 1999, J Clin Endocrinol Metab, 84, 1966

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Metadata

Authors
Aversa, A., Bruzziches, R., Francomano, D., Greco, E. A., Fornari, R., Luigi, L. D., Lenzi, A., & Migliaccio, S.
Affiliations
  • Sapienza University of Rome (IT)
  • Foro Italico University of Rome (IT)
ORCID
Venue
The Aging Male
Publisher
Informa UK Limited
Published
2012-03-23
Volume
15
Issue
2
Pages
96-102
ISSN
  • 1368-5538 (ISSN-L)
  • 1473-0790
DOI
10.3109/13685538.2011.631230
OpenAlex
W2145291570
Cited by
108
References
52
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 4
FWCI
10.78
Type
journal article
Language
en
Open access
Locations
  • The Aging Male (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone undecanoate, testosterone replacement therapy, bone mineral density, andropause, metabolic syndrome, obesity, osteopenia, middle-aged men, serum testosterone, C-reactive protein, estradiol, medication adherence
MeSH terms
Aged, Androgens, Femur, Humans, Hypogonadism, Male, Middle Aged, Obesity, Spine, Testosterone, Bone Density, Metabolic Syndrome

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