Antifungal Activity of Turkish Honey against Candida spp. and Trichosporon spp: an in vitro evaluation

Koc, Ayşe Nedret; Silici, Sibel; Ercal, Bariş Derya; Kasap, Filiz; Hörmet-Öz, Hatice Tuna; Mavus-Buldu, Hikmet

doi:10.3109/13693780802572554

Cited by 61Bee Products Chemical AnalysisAntifungal resistance and susceptibilityEssential Oils and Antimicrobial Activity

Antifungal Activity of Turkish Honey against Candida spp. and Trichosporon spp: an in vitro evaluation

Koc, Ayşe Nedret, Silici, Sibel, Ercal, Bariş Derya, Kasap, Filiz, Hörmet-Öz, Hatice Tuna, Mavus-Buldu, Hikmet·2009·Medical Mycology

DOI 10.3109/13693780802572554

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Abstract

Abstract Honey samples from different floral sources were evaluated for their ability to inhibit the growth of 40 yeast strains (Candida albicans, C. krusei, C. glabrata and Trichosoporon spp.). Broth microdilution method (CLSI, M27-A2) was used to assess the activity of the honeys against yeasts at different concentrations ranging from 1.25-80% (v/v). All of the yeast strains tested were inhibited by honeys in this study. Broth microdilution assay revealed that inhibition of growth depends on the type and concentration of honey as well as the test pathogen. Little or no antifungal activity was seen at honey concentrations <2%. Rhododendron and multifloral honeys have generally more inhibitory effect than eucalyptus and orange honeys (P<0.05). Fluconazole-resistant yeast strains were examined for their susceptibility to honeys. This study demonstrated that, in vitro, these honeys had antifungal activity at the high concentration of 80% (v/v) in these fluconazole-resistant strains. Further studies are now required to demonstrate if this antifungal activity has any clinical application.

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Few studies have focused on the antifungal properties of honey.
“However, although a number of studies have investigated the antimicrobial properties of honey against bacteria, few have focused on its antifungal properties [248,249,250,251,252,253].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [253]

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Authors: Koc, A. N., Silici, S., Ercal, B. D., Kasap, F., Hörmet-Öz, H. T., & Mavus-Buldu, H.
Affiliations: Erciyes University (TR)
ORCID: Hörmet-Öz, Hatice Tuna
Venue: Medical Mycology
Publisher: Oxford University Press (OUP)
Published: 2009-11-03
Volume: 47
Issue: 7
Pages: 707-712
ISSN: 0268-1218 (ISSN-L)
1369-3786
1460-2709
DOI: 10.3109/13693780802572554
OpenAlex: W2116901681
Cited by: 61
References: 34
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 11 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 1 · 2013: 6 · 2012: 6
FWCI: 4.39
Type: journal article
Language: en
Open access: closed
Locations: Medical Mycology (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords: honey, antifungal activity, Candida albicans, Candida krusei, Candida glabrata, Trichosporon, yeast, multifloral honey, eucalyptus honey, fluconazole resistance, antifungal natural products
MeSH terms: Antifungal Agents, Candida, Honey, Microbial Sensitivity Tests, Trichosporon, Turkey, Fluconazole

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Antifungal Activity of Turkish Honey against Candida spp. and Trichosporon spp: an in vitro evaluation

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