Possible mechanisms of action of the hypotensive effect of Annona muricata(soursop) in normotensive Sprague–Dawley rats
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CONTEXT: Annona muricata Linn (Annonaceae) (soursop) is a food plant reported to have antihypertensive properties. OBJECTIVE: We investigated the blood pressure reducing effect of its aqueous leaf extract and the possible mechanisms that may be responsible. METHODS: Intravenous administration of an aqueous leaf extract (9.17-48.5 mg/kg) of A. muricata on the mean arterial pressure and heart rate were recorded invasively on anaesthetized, normotensive Sprague-Dawley rats. Contractile responses of rat aortic rings to the extract (0.5-4.0 mg/mL) were studied using standard organ bath techniques. RESULTS: A. muricata (9.17-48.5 mg/kg) caused significant (p < 0.05) dose-dependent reduction in blood pressure without affecting the heart rates. The hypotensive effects were unaffected by atropine (2 mg/kg), mepyramine (5 mg/kg), propranolol (1 mg/kg) and L-NAME (5 mg/kg). A. muricata leaf aqueous extract significantly (p < 0.05) relaxed phenylephrine (10(-9)-10(-4) M) and 80 mM KCl induced contractions in endothelium intact and denuded aortic rings; and caused a significant (p < 0.05) rightward shift of the Ca(2+) dose response curves in Ca(2+)-free Kreb's solution containing 0.1 mM EGTA. CONCLUSIONS: The hypotensive effects of A. muricata are not mediated through muscarinic, histaminergic, adrenergic and nitric oxide pathways, but through peripheral mechanisms involving antagonism of Ca(2+).
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A. muricata's hypotensive effect could be attributed to the alkaloid compounds found in the plant's leaves.
“A. muricata’s hypotensive effect could be attributed to the alkaloid compounds found in the plant’s leaves.”
From Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties (2023) · cites this paper as [84]
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- Authors
- Nwokocha, C. R., Owu, D. U., Gordon, A., Thaxter, K., McCalla, G., Ozolua, R. I., & Young, L.
- Affiliations
- University of the West Indies System (JM)
- University of Calabar (NG)
- University of the West Indies (JM)
- University of Benin (NG)
- Corresponding author
- Nwokocha, Chukwuemeka R.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2012-09-11
- Volume
- 50
- Issue
- 11
- Pages
- 1436-1441
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2007302622
- Cited by
- 57
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 10 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmaceutical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Traditional and Medicinal Uses of Annonaceae
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- Annona muricata, antihypertensive effect, aqueous leaf extract, blood pressure reduction, aortic relaxation, calcium channel blockade, phenylephrine-induced contraction, EGTA, Sprague-Dawley rats
- MeSH terms
- Animals, Antihypertensive Agents, Aorta, Thoracic, Blood Pressure, Calcium, Dose-Response Relationship, Drug, Endothelium, Vascular, Heart Rate, Male, Muscle Contraction, Rats, Sprague-Dawley, Plant Leaves, Annona, Rats
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