The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells
Abstract
The use of engineered nanoparticles in the food sector is anticipated to increase dramatically, whereas their potential hazards for the gastrointestinal tract are still largely unknown. We investigated the cytotoxic and DNA-damaging effects of several types of nanoparticles and fine particles relevant as food additives (TiO2 and SiO2) or for food packaging (ZnO and MgO) as well as carbon black on human intestinal Caco-2 cells. All particles, except for MgO, were cytotoxic (LDH and WST-1 assay). ZnO, and to lesser extent SiO2, induced significant DNA damage (Fpg-comet), while SiO2 and carbon black were the most potent in causing glutathione depletion. DNA damage by TiO2 was found to depend on sample processing conditions. Interestingly, application of different TiO2 and ZnO particles revealed no relation between particle surface area and DNA damage. Our results indicate a potential hazard of several food-related nanoparticles which necessitate investigations on the actual exposure in humans.
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Cites
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Cited by
Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties
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Nanotoxicology: An Interdisciplinary Challenge
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Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract
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A review of mammalian toxicity of ZnO nanoparticles
Vandebriel, R., & De Jong, W. (2012) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s23932 · Cited by 494
Sharma, V., Singh, P., Pandey, A. K., & Dhawan, A. (2012) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2011.12.009 · Cited by 468
Metadata
- Authors
- Gerloff, K., Albrecht, C., Boots, A. W., Förster, I., & Schins, R. P. F.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2009-11-30
- Volume
- 3
- Issue
- 4
- Pages
- 355-364
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2137098239
- Cited by
- 263
- References
- 37
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gerloff, K., Albrecht, C., Boots, A. W., Förster, I., & Schins, R. P. F. (2009). Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology. https://doi.org/10.3109/17435390903276933
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