Cited by 556Nanoparticles: synthesis and applicationsNanotechnology research and applicationsGraphene and Nanomaterials Applications

Nanotoxicology: An Interdisciplinary Challenge

Krug, Harald F., Wick, Peter·2011·Angewandte Chemie International Edition

Abstract

The increasing consumption of products containing nanomaterials that can be currently observed and forecasts of new developments and applications fan the fear of individuals and organizations regarding new risks to health. Considering experiences gained from previous technology developments, such fears are not completely unfounded. But are they really justified? And is it justified, moreover, to speak of “nanotoxicology” as a new discipline? This Review seeks to cast light on the phenomena that may occur as nanoobjects interact with cells, tissues, and organisms. Furthermore, we will demonstrate that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable. We will point out the aspect of reliability with specific examples from the literature and will not address specific (nano)materials. In particular, inadequate methods will be described together with recommendations how to avoid this in the future, thereby contributing to a sustainable improvement of the available data.

Integrity signals

Registry

Crossref · 10.1002/anie.201001037

Cites

166 of 166 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Toxicity induced by micro-nano particles is not only dose-dependent but also related to particle physicochemical characteristics and their effect on cellular interactions and uptake.

    “As studies with engineered nanoparticles have suggested and investigations of plastic particles are starting to indicate, toxicity induced by micro-nano particles is not only dose-dependent but also related to particle physicochemical characteristics and their effect on cellular interactions and uptake (81, 82).”

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Authors
Krug, H. F., & Wick, P.
Affiliations
Empa (CH)
Corresponding author
Krug, Harald F.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2011-01-11
Volume
50
Issue
6
Pages
1260-1278
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2169703093
Cited by
556
References
166
Citations by year
2026: 5 · 2025: 12 · 2024: 28 · 2023: 23 · 2022: 25 · 2021: 31 · 2020: 32 · 2019: 30 · 2018: 41 · 2017: 40 · 2016: 30 · 2015: 45 · 2014: 62 · 2013: 70 · 2012: 51
FWCI
3.29
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
  • DORA Empa (Swiss Federal Laboratories for Materials Science and Technology (Empa)) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
Keywords
nanotoxicology, nanomaterials, nanomaterial-cell interactions, health risks, research reliability, methodological quality, data quality improvement, interdisciplinary research
MeSH terms
Blood-Brain Barrier, Humans, Lung, Skin, Nanostructures

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