Cited by 47Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Intramuscular Abdominal Wall Endometriosis Treated by Ultrasound-Guided Ethanol Injection

Open access
Bozkurt, M., Cil, A. S., Bozkurt, D. K.·2014·Clinical Medicine & Research

Abstract

Case ReportEndomet riosis is described as the presence of endometrial tissue outside the uterine cavity.Endometriosis is most commonly located in the ovaries, bowel, or the tissue lining in the pelvis.It may develop in virtually every organ in extrapelvic sites.The abdominal wall is an uncommon site of the extrapelvic location, where it mostly occurs in an old surgical scar.Abdominal wall endometriosis (AWE) appears following the implantation of endometrial cells into the soft tissues of the abdominal wall after open uterine surgeries like Caesarean sections.The incidence rate is reported at 0.4% to 0.1%. 1 The disease is characterized with the triad of mass in the abdominal wall, periodic pain associated with menses, and history of abdominal surgery.Its treatment is recognized to be broad surgical excision.There are reports suggesting that successful results can be achieved in patients with pelvic endometriosis by injecting ultrasound-guided alcohol into the lesion and performing sclerotherapy as well as surgical treatment.2,3 However, to the best of our knowledge, the literature contains no cases of intramuscular AWE treated by injecting ultrasoundguided alcohol.This case report describes the clinical and radiological findings of a patient who had intramuscular AWE following Caesarean section and received sclerotherapy by injecting ultrasound-guided alcohol. Case ReportWe report a 25-year-old female patient (G2 P2 A0 C0) who underwent a Caesarean section 7 years ago for post-term pregnancy with no response to induction.The patient, who underwent a second Caesarean section 4 years ago, was admitted to another clinic 26 months after this operation with complaints of

AI snapshot

Written from the paper’s full text.

TL;DR

This case report describes a 25-year-old woman with intramuscular abdominal wall endometriosis (AWE) in the rectus abdominis muscle following two Caesarean sections, treated with ultrasound-guided injection of 95% ethanol rather than surgical excision. The authors report complete resolution of pain and no recurrence over a 9-month follow-up, claiming this is the first reported case of intramuscular AWE treated by ethanol sclerotherapy.

Key findings

  • The patient, a 25-year-old female (G2 P2 A0 C0) with two prior Caesarean sections, presented with cyclic pain in the Caesarean scar and a palpable mass measuring approximately 3 cm × 1.5 cm on the right side of the scar; the interval between the previous Caesarean section and clinical symptoms was 2.1 years.
  • Imaging showed a heterogeneous hypoechoic, irregularly marginated lesion (30 mm × 14 mm) in the rectus abdominis muscle on ultrasound, a weakly contrasting mass with heterogeneous hypo-hyperintense areas on MRI, and restricted diffusion with ADC values of 0.95×10⁻³ mm²/s; diagnosis was confirmed by fine needle aspiration showing endometrial glands, stroma, and smooth muscle cells.
  • After ultrasound-guided injection of 1 cc 95% ethanol (22-gauge needle) plus 3 months of oral contraceptives, the patient reported complete disappearance of pain and no recurrence was observed during the 9-month follow-up.
  • The authors cite prior literature: AWE incidence reported at 0.4% to 0.1%; a 445-patient study found palpable mass in 96% and pain in 86% (cyclic in 57%); a 33-patient retrospective study reported Caesarean scar endometriosis incidence of 0.29% and episiotomy scar incidence of 0.01%; previous Caesarean section increased relative risk of AWE by 27 times; recurrence rate after surgery reported at 4.3%.

Methods

  • Design: single case report describing clinical and radiological findings of one patient with intramuscular AWE.
  • Data/sample: one 25-year-old woman with a history of two Caesarean sections, evaluated with ultrasound (LOGIQ 9, linear 12–14 MHz and convex 2–5 MHz transducers), contrast-enhanced abdominal CT, and 1.5-Tesla MRI (including diffusion-weighted sequences), followed by ultrasound-guided fine needle aspiration biopsy.
  • Intervention/analysis: ultrasound-guided sclerotherapy with 1 cc 95% ethanol injected into various parts of the lesion, followed by pelvic ultrasound and MRI to check for complications, 3 months of oral contraceptives, and an additional 3-month follow-up (9 months total).

Limitations

  • Stated by the authors: no prospective studies are available on prevention of AWE; literature review revealed no studies reporting the incidence of recurrence in AWE patients treated with ethanol injection; further investigations of large series are needed to compare surgical operation with ethanol injection treatment.
  • Evident from the text: this is a single case report with only a 9-month follow-up, so no generalizable efficacy or recurrence data can be drawn; the authors themselves note that intralesional ethanol may cause difficult-to-repair necrosis in large lesions and chemical peritonitis or severe pain if the focus extends intraperitoneally, and that such patients may require multiple sessions rather than a single injection.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.3121/cmr.2013.1183

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 12 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    The patient's pain completely disappeared during the 9-month follow-up.

    “The patient reported that her pain completely disappeared during the 9-month follow-up, and no recurrence was observed.”
    • Also stated in: § Discussion · plain
      “The patient's pain completely disappeared after the treatment, and there was no recurrence during the 9-month follow-up.”
    Quote in the paperSubstantial claim
  • Findingown data

    MRI showed a weakly contrasting mass, 3 cm x 1.5 cm, containing heterogeneous hypo-hyperintense areas in the suprapubic region on the right rectus abdominis muscle in T1 and T2A sequences, causing asymmetric thickening.

    “MRI imaging showed a weakly contrasting mass, 3 cm x 1.5 cm, containing heterogeneous hypo-hyperintense areas in the suprapubic region on the right rectus abdominis muscle in the T1 and T2A sequences, causing asymmetric thickening (figure 2).”
    Quote in the paperSubstantial claim
  • Findingown data

    The ADC value of the mass was 0.95×10 -3 mm 2 /sn.

    “Apparent diffusion coefficient (ADC) values were found to be 0.95×10 -3 mm 2 /sn.”
    Quote in the paperNot a substantial claim
  • Findingown data

    Diffusion-weighted MRI showed a slight signal increase secondary to restricted diffusion in the mass.

    “Diffusion-weighted images showed a slight signal increase secondary to restricted diffusion in the mass.”
    Quote in the paperNot a substantial claim
  • Findingown data

    Ultrasound showed a heterogeneous hypoechoic, irregularly marginated lesion, 30 mm x14 mm, in the lower right quadrant in the rectus abdominis muscle.

    “Superficial ultrasound scan showed a heterogeneous hypoechoic, irregularly marginated lesion, 30 mm x14 mm, in the lower right quadrant in the rectus abdominis muscle (figure 1A).”
    Quote in the paperSubstantial claim
  • May combine two claims. 7
  • Classified as probably not a substantial claim. 6
  • May combine two claims.

    Findingown data

    Contrast-enhanced abdominal CT showed asymmetrical thickening at the inferior portion of the left rectus abdominis muscle and a hyper-intense mass suggestive of hematoma.

    “The patient's contrast enhanced abdominal computed tomography scan taken at another hospital showed an asymmetrical thickening at the inferior portion of the left rectus abdominis muscle and a hyper-intense mass, suggestive of hematoma (figure 1B).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    The time between the previous Caesarean section and clinical symptoms was 2.1 years.

    “The time between previous Cesarean section and clinical symptoms was 2.1 years.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    The patient's pain was cyclic, intensified particularly in the first 2 days of menstruation, and significantly restricted her daily activities.

    “The patient stated that the pain was cyclic, intensified particularly in the first 2 days of menstruation, and it significantly restricted her daily activities.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Interpretationnone given

    Literature review revealed no studies reporting the incidence of recurrence in AWE patients treated with ethanol injection.

    “Literature review revealed no studies reporting the incidence of recurrence in AWE patients treated with ethanol injection.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductnone given

    Approval was obtained from the patient and the hospital's ethics committee.

    “Approval was obtained from the patient and the hospital's ethics committee.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    There are reports suggesting successful results can be achieved in patients with pelvic endometriosis by injecting ultrasound-guided alcohol into the lesion and performing sclerotherapy as well as surgical treatment.

    “There are reports suggesting that successful results can be achieved in patients with pelvic endometriosis by injecting ultrasound-guided alcohol into the lesion and performing sclerotherapy as well as surgical treatment.2,3”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites [2]

      Not checked in the free run.

    • cites [3]

      Not checked in the free run.

  • May combine two claims.

    Premisecitation

    Hormonal treatment offers temporary alleviation of symptoms, but recurrence is common after cessation of treatment.

    “Hormonal treatment offers temporary alleviation of symptoms, but recurrence is common after cessation of treatment.13”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [13]

      Not checked in the free run.

  • May combine two claims.

    Interpretationown data

    Sclerotherapy with ultrasound-guided ethanol injection into the lesion, with short-term hormonal treatment, eliminates patients' complaints and results in no recurrence in the short term.

    “Contrary to conventional treatments, the patients' complaints are eliminated by sclerotherapy with ultrasound-guided ethanol injection into the lesion, a minimally invasive method, and an accompanying short-term hormonal treatment, and no recurrence in the short term.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: The patient's pain relief and absence of recurrence were attributable to the ultrasound-guided ethanol injection rather than to the concomitant oral contraceptive treatment or natural course.
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationcitation

    Ultrasound-guided fine needle aspiration can be a useful and less invasive method to confirm abdominal wall endometriosis.

    “Ultrasound-guided fine needle aspiration can be a useful and less invasive method to confirm abdominal wall endometriosis.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [9]

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Interpretationnone given

    Ultrasound-guided ethanol injection is a minimally invasive method.

    “Contrary to conventional treatments, the patients' complaints are eliminated by sclerotherapy with ultrasound-guided ethanol injection into the lesion, a minimally invasive method, and an accompanying short-term hormonal treatment, and no recurrence in the short term.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Caesarean section has been reported to be the major risk factor in abdominal wall endometriosis, and a previous Caesarean section increased the relative risk of AWE by 27 times.

    “Caesarean section has been reported to be the major risk factor in abdominal wall endometriosis, and it has been observed that a previous Caesarean section increased the relative risk of AWE by 27 times.6,7”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [6]

      Not checked in the free run.

    • cites [7]

      Not checked in the free run.

11 of 11
  • The paper relies on this without support.

    The patient's pain relief and absence of recurrence were attributable to the ultrasound-guided ethanol injection rather than to the concomitant oral contraceptive treatment or natural course.

    “The patient's pain completely disappeared after the treatment, and there was no recurrence during the 9-month follow-up.”
    “Oral contraceptives were started for 3 months to reduce the risk of recurrence.”
  • The paper relies on this without support.

    The ultrasound-guided ethanol injection did not cause significant complications.

    “After the procedure, pelvic ultrasound and pelvic MRI were performed to check for any complications.”
  • The paper relies on this without support.

    The patient's self-reported pain disappearance is a valid measure of treatment success.

    “The patient reported that her pain completely disappeared during the 9-month follow-up, and no recurrence was observed.”
3 of 3

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Ultrasound typically reveals hypoechoic masses, while MRI detects hemorrhagic foci (T1 hypointensity, T2 hyperintensity) and defines lesion depth.

    “Ultrasound typically reveals hypoechoic masses, while MRI detects hemorrhagic foci (T1 hypointensity, T2 hyperintensity) and defines lesion depth [4, 20].”

    From Abdominal wall endometriosis in a cesarean scar: a case report (2025) · cites this paper as [20]

    The case description reports a heterogeneous hypoechoic lesion on ultrasound, and the Discussion describes MRI findings consistent with hemorrhage and fibrosis in the rectus abdominis muscle (page not provided). But this single case does not establish what ultrasound typically shows; MRI findings were heterogeneous on both T1- and T2-weighted images, not the specified T1-hypointense/T2-hyperintense pattern. MRI located the lesion within the muscle, but the paper does not explicitly say it defines lesion depth. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • CT places the lesion on the opposite side

    Minor

    The CT description places the mass in the left rectus abdominis muscle, while the ultrasound and MRI descriptions place it in the right rectus abdominis muscle.

1 of 1

Cites

Flagged first, then by citations

1 of the 20 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Collins AM, Power KT, Gaughan B, Hill AD, Kneafsey B. Abdominal wall reconstruction for a large caesarean scar endometrioma. Surgeon 2009;7:252-253.

Cited by

Sorted by citations

Authors
Bozkurt, M., Cil, A. S., & Bozkurt, D. K.
Affiliations
Kafkas University (TR)
Corresponding author
Bozkurt, M.
Venue
Clinical Medicine & Research
Published
2014-03-25
Volume
12
Issue
3-4
Pages
160-165
ISSN
  • 1539-4182 (ISSN-L)
  • 1554-6179
OpenAlex
W2101422671
Cited by
47
References
20
Citations by year
2025: 4 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 11 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 2
FWCI
2.02
Type
journal article
Language
en
Open access
Locations
  • Clinical Medicine & Research (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
abdominal wall endometriosis, sclerotherapy, cesarean section, extrapelvic endometriosis, postoperative endometriosis, abdominal wall mass
MeSH terms
Adult, Ethanol, Endometriosis, Female, Humans, Muscular Diseases, Solvents, Injections, Intralesional, Sclerotherapy, Ultrasonography, Interventional, Abdominal Wall

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