Malignant transformation of abdominal wall endometriosis to clear cell carcinoma: Case report and review of the literature
Open accessAbstract
Objective To report a case of clear cell carcinoma in abdominal wall endometriosis after cesarean section.Design Case report.Setting A French oncology center.Patient(s) A 38-year-old woman who developed a 10-cm mass in the abdominal wall muscles, 13 years after a cesarean section.Intervention(s) Abdominal wall resection and chemotherapy.Main outcome measure(s) Clinical outcome.Result(s) The diagnosis of clear cell carcinoma in abdominal wall endometriosis was confirmed, and wide surgical excision with abdominal wall reconstruction was performed after three courses of chemotherapy.Conclusion(s) The malignant transformation of abdominal wall endometrioma has not been clearly elucidated, owing to its rarity. However, the eventuality should always be considered, and the prognosis improved through wide surgical excision.
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CT scan findings play a primary role in staging, as CT is more sensitive than ultrasound in detecting pelvic lymphadenopathy and is more able to assess distant thoracic metastases than MRI.
“Additionally, CT scan findings play a primary role in staging, as this imaging technique is more sensitive than ultrasound in detecting pelvic lymphadenopathy and is more able to assess distant thoracic metastases than MRI [52].”
From Malignancy in Abdominal Wall Endometriosis: Is There a Way to Avoid It? A Systematic Review (2024) · cites this paper as [52]
Clear cell carcinoma arising from abdominal wall endometriosis presents as a slow-growing mass adjacent to a scar from previous surgery and cyclical abdominal pain.
“Clear cell carcinoma arising from the abdominal wall endometriosis presents as a slow-growing mass adjacent to a scar from previous surgery and cyclical abdominal pain [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
The management of clear cell carcinoma of the abdominal wall necessitates cytoreductive surgery with considerations for adjuvant platinum-based chemotherapy.
“The management of clear cell carcinoma of the abdominal wall necessitates cyto reductive surgery with considerations for adjuvant platinum-based chemotherapy [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
The most common histologic subtype of extra-gonadal malignant endometriosis is endometrioid carcinoma (69.1%) followed by sarcoma (25%) and clear cell carcinoma (4.5%).
“The most common histologic subtype of extra-gonadal malignant endometriosis is endometrioid carcinoma (69.1%) followed by sarcoma (25%) and clear cell carcinoma (4.5%) [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
When malignant endometriosis involves the abdominal wall, the predominant histological subtype observed is clear cell carcinoma (66%) followed by endometrioid carcinoma (24%).
“However, when malignant endometriosis involves the abdominal wall, the predominant histological subtype observed is clear cell carcinoma (66%) followed by endometrioid carcinoma (24%) [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
Clear cell carcinoma of the abdominal wall presents as an abdominal mass that develops adjacent to a previous surgical scar.
“Clear cell carcinoma of the abdominal wall presents as an abdominal mass that develops adjacent to a previous surgical scar [5, 17].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
The management of clear cell carcinoma arising from abdominal wall endometriosis consists of cytoreductive surgery with considerations for adjuvant chemotherapy.
“The management of clear cell carcinoma arising from abdominal wall endometriosis consists of cytoreductive surgery with considerations for adjuvant chemotherapy [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
The cancer antigen CA-125 is a non-specific biomarker elevated in both ovarian malignancy and advanced endometriosis.
“The cancer antigen, CA-125, is a non-specific biomarker elevated in both ovarian malignancy and advanced endometriosis [5].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
Surgical intervention for clear cell carcinoma arising from abdominal wall endometriosis necessitates wide excision of the abdominal wall tumor to achieve healthy margins, hysterectomy, bilateral salpingo-oophorectomy, and abdominal wall reconstruction.
“Surgical intervention necessitates wide excision of the abdominal wall tumor to achieve healthy margins, hysterectomy, bilateral salpingo-oophorectomy, and abdominal wall reconstruction [5, 17].”
From Clear cell carcinoma arising from abdominal wall endometriosis—A report on two cases and literature review (2022) · cites this paper as [5]
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“The cancer antigen, CA-125, is a non-specific biomarker elevated in both ovarian malignancy and advanced endometriosis [5].”
BackgroundInfluentialTransformation of Abdominal Wall Endometriosis to Clear Cell Carcinoma
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“desmoids, sarcomas, metastatic diseases, pyogenic granulomas, and melanomas [68,69].”
Background
- Authors
- Bats, A. S., Zafrani, Y., Pautier, P., Duvillard, P., & Morice, P.
- Affiliations
- Institut Gustave Roussy (FR)
- Corresponding author
- Morice, Philippe
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 90
- Issue
- 4
- Pages
- 1197.e13-1197.e16
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1990589620
- Cited by
- 77
- References
- 13
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 2 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 6
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Metastasis and carcinoma case studies
- Health Sciences › Medicine › Surgery › Teratomas and Epidermoid Cysts
- Keywords
- abdominal wall endometriosis, clear cell carcinoma, malignant transformation, endometrioma, cesarean section, abdominal wall resection, abdominal wall reconstruction, chemotherapy, prognosis
- MeSH terms
- Abdominal Neoplasms, Adult, Cell Transformation, Neoplastic, Endometriosis, Female, Humans, Sarcoma, Clear Cell, Abdominal Wall
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