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Cited by 24Gastrointestinal motility and disordersMicrobial Metabolites in Food BiotechnologyGut microbiota and health

Partially hydrolyzed guar gum is associated with improvement in gut health, sleep, and motivation among healthy subjects

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Abe, Aya, Morishima, So, Kapoor, Mahendra P., Inoue, Ryo, Tsukahara, Takamitsu, Naito, Yuji, Ozeki, Makoto·2023·Journal of Clinical Biochemistry and Nutrition
DOI 10.3164/jcbn.22-75PMC PMC10017317
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Abstract

Partially hydrolyzed guar gum dietary fiber is well recognized for a number of health benefits. In the present study, we aim to investigate the effects of partially hydrolyzed guar gum on constipation, intestinal microbiota as well as mental health in healthy subjects. In the randomized, parallel, double-blind, and placebo-controlled study the enrolled healthy men and women volunteers took either 3 g/day (T3) or 5 g/day (T5) of dietary fiber intakes for eight consecutive weeks compared to placebo (T0). The fecal characteristics, fecal microbiota, defecation characteristics, and quality of life (QOL) questionnaire were investigated. The results revealed a significant suppression in fecal potent harmful mucolytic bacteria in the T3 and T5 groups compared to the T0 group. The defecation frequency, excretory feeling, and scores of sleep and motivation questionnaire were also improved in the dietary fiber intake groups, showing a significant difference in the T5 group compared to the T0 group. In summary, the consumption of partially hydrolyzed guar gum dietary fiber is found effective in suppressing the potent harmful mucolytic bacteria that could be associated with the improvement of constipation-related symptoms including mental health in terms of sleep and motivation among the healthy subjects.

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  1. [1]Nakaji S Sugawara K Saito D Trends in dietary fiber intake in Japan over the last century. Eur J Nutr 2002; 41: 222– 227. 12395216
  2. [2]Clemens R Kranz S Mobley AR Filling America’s fiber intake gap: summary of a roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr 2012; 142: 1390S– 1401S. 22649260
  3. [3]Stephen AM Champ MM Cloran SJ Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health. Nutr Res Rev 2017; 30: 149– 190. 28676135
  4. [4]Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013; 5: 1417– 1435. 23609775 PMC3705355
  5. [5]Holscher HD. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes 2017; 8: 172– 184. 28165863 PMC5390821
  6. [6]Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444: 1027– 1031. 17183312
  7. [7]Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Human gut microbes associated with obesity. Nature 2006; 444: 1022– 1023. 17183309
  8. [8]Cani PD Amar J Iglesias MA Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56: 1761– 1772. 17456850
  9. [9]Dabke K, Hendrick G, Devkota S. The gut microbiome and metabolic syndrome. J Clin Invest 2019; 129: 4050– 4057. 31573550 PMC6763239
  10. [10]Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med 2016; 375: 2369– 2379. 27974040
  11. [15]Taylor AM, Holscher HD. A review of dietary and microbial connections to depression, anxiety, and stress. Nutr Neurosci 2020; 23: 237– 250. 29985786
  12. [16]Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev 2020; 53: 101340. 32668369
  13. [17]Li Y, Hao Y, Fan F, Zhang B. The role of microbiome in insomnia, circadian disturbance and depression. Front Psychiatry 2018; 9: 669. 30568608 PMC6290721
  14. [18]Wiest R, Albillos A, Trauner M, Bajaj JS, Jalan R. Targeting the gut-liver axis in liver disease. J Hepatol 2017; 67: 1084– 1103. 28526488
  15. [19]Reid G, Jass J, Sebulsky MT, McCormick JK. Potential uses of probiotics in clinical practice. Clin Microbiol Rev 2003; 16: 658– 672. 14557292 PMC207122
  16. [20]Nagpal R, Kumar A, Kumar M, Behare PV, Jain S, Yadav H. Probiotics, their health benefits and applications for developing healthier foods: a review. FEMS Microbiol Lett 2012; 334: 1– 15. 22568660
  17. [21]Thompson RS, Vargas F, Dorrestein PC, Chichlowski M, Berg BM, Fleshner M. Dietary prebiotics alter novel microbial dependent fecal metabolites that improve sleep. Sci Rep 2020; 10: 3848. 32123201 PMC7051969
  18. [22]Dehghani Soltani M Meftahizadeh H Barani M Guar (Cyamopsis tetragonoloba L.) plant gum: from biological applications to advanced nanomedicine. Int J Biol Macromol 2021; 193 (Pt B): 1972– 1985. 34748787
  19. [23]Rao TP, Quartarone G. Role of guar fiber in improving digestive health and function. Nutrition 2019; 59: 158– 169. 30496956
  20. [24]Slavin JL, Greenberg NA. Partially hydrolyzed guar gum: clinical nutrition uses. Nutrition 2003; 19: 549– 552. 12781858
  21. [25]Ohashi Y, Sumitani K, Tokunaga M, Ishihara N, Okubo T, Fujisawa T. Consumption of partially hydrolysed guar gum stimulates Bifidobacteria and butyrate-producing bacteria in the human large intestine. Benef Microbes 2015; 6: 451– 455. 25519526
  22. [26]Okubo T Ishihara N Takahashi H Effects of partially hydrolyzed guar gum intake on human intestinal microflora and its metabolism. Biosci Biotechnol Biochem 1994; 58: 1364– 1369.
  23. [27]Yasukawa Z Inoue R Ozeki M Effect of repeated consumption of partially hydrolyzed guar gum on fecal characteristics and gut microbiota: a randomized, double-blind, placebo-controlled, and parallel-group clinical trial. Nutrients 2019; 11: 2170. 31509971 PMC6769658
  24. [28]Kapoor MP Koido M Kawaguchi M Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals—A randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study. J Funct Foods 2020; 72: 104067.
  25. [29]Pylkas AM, Juneja LR, Slavin JL. Comparison of different fibers for in vitro production of short chain fatty acids by intestinal microflora. J Med Food 2005; 8: 113– 116. 15857221
  26. [30]Velázquez M, Davies C, Marett R, Slavin JL, Feirtag JM. Effect of oligosaccharides and fibre substitutes on short-chain fatty acid production by human faecal microflora. Anaerobe 2000; 6: 87– 92.
  27. [31]Kapoor MP, Sugita M, Fukuzawa Y, Okubo T. Impact of partially hydrolyzed guar gum (PHGG) on constipation prevention: a systematic review and meta-analysis. J Funct Foods 2017; 33: 52– 66.
  28. [32]Polymeros D Beintaris I Gaglia A Partially hydrolyzed guar gum accelerates colonic transit time and improves symptoms in adults with chronic constipation. Dig Dis Sci 2014; 59: 2207– 2214. 24711073
  29. [33]Alam NH Ashraf H Kamruzzaman M Efficacy of partially hydrolyzed guar gum (PHGG) supplemented modified oral rehydration solution in the treatment of severely malnourished children with watery diarrhoea: a randomised double-blind controlled trial. J Health Popul Nutr 2015; 34: 3. 26825757 PMC5026008
  30. [34]Rushdi TA, Pichard C, Khater YH. Control of diarrhea by fiber-enriched diet in ICU patients on enteral nutrition: a prospective randomized controlled trial. Clin Nutr 2004; 23: 1344– 1352. 15556256
  31. [35]Homann HH, Kemen M, Fuessenich C, Senkal MZV. Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition. J Parenter Enter Nutr 1994; 18: 486– 490. 7602722
  32. [36]Hung TV, Suzuki T. Dietary fermentable fibers attenuate chronic kidney disease in mice by protecting the intestinal barrier. J Nutr 2018; 148: 552– 561. 29659957
  33. [37]Takayama S Katada K Takagi T Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis. World J Gastroenterol 2021; 27: 2160– 2176. 34025071 PMC8117741
  34. [38]Sakakida T Ishikawa T Doi T Water‐soluble dietary fiber alleviates cancer‐induced muscle wasting through changes in gut microenvironment in mice. Cancer Sci 2022; 113: 1789– 1800. 35201655 PMC9128179
  35. [39]Okamura T Hamaguchi M Mori J Partially hydrolyzed guar gum suppresses the development of sarcopenic obesity. Nutrients 2022; 14: 1157. 35334814 PMC8955723
  36. [40]Dall' Alba V, Silva FM, Antonio JP, et al. Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial. Br J Nutr 2013; 110: 1601– 1610. 23551992
  37. [41]Kapoor MP, Ishihara N, Okubo T. Soluble dietary fibre partially hydrolysed guar gum markedly impacts on postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic hormones over time in healthy and glucose intolerant subjects. J Funct Foods 2016; 24: 207– 220.
  38. [42]Takagi T Inoue R Oshima A Typing of the gut microbiota community in Japanese subjects. Microorganisms 2022; 10: 664. 35336239 PMC8954045
  39. [43]Morishima S Oda N Ikeda H Altered fecal microbiotas and organic acid concentrations indicate possible gut dysbiosis in university rugby players: an observational study. Microorganisms 2021; 9: 1687. 34442766 PMC8400784
  40. [44]Hashimoto Y Hamaguchi M Kaji A Intake of sucrose affects gut dysbiosis in patients with type 2 diabetes. J Diabetes Investig 2020; 11: 1623– 1634. PMC7610116 32412684
  41. [45]Bolyen E Rideout JR Dillon MR Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol 2019; 37: 852– 857. 31341288 PMC7015180
  42. [46]Glöckner FO Yilmaz P Quast C 25 years of serving the community with ribosomal RNA gene reference databases and tools. J Biotechnol 2017; 261: 169– 176. 28648396
  43. [47]Ushida K, Sakata T. Effect of pH on oligosaccharide fermentation by porcine cecal digesta. Nihon Chikusan Gakkaiho 1998; 69: 100– 107.
  44. [48]Morishima S Aoi W Kawamura A Intensive, prolonged exercise seemingly causes gut dysbiosis in female endurance runners. J Clin Biochem Nutr 2021; 68: 253– 258. 34025029 PMC8129978
  45. [49]Maxwell C. Sensitivity and accuracy of the visual analogue scale: a psycho-physical classroom experiment. Br J Clin Pharmacol 1978; 6: 15– 24. 666944 PMC1429397
  46. [51]Yamamoto Y, Tanaka H, Takase H, Shirakawa M. Standardization of revised version of OSA sleep inventory for middle age and aged. Brain Sci Ment Disord 1999; 10: 401– 409.
  47. [52]Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K. Translation, adaptation, and validation of the SF-36 Health Survey for Use in Japan. J Clin Epidemiol 1998; 51: 1037– 1044. 9817121
  48. [53]Taras D, Simmering R, Collins MD, Lawson PA, Blaut M. Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 2002; 52 (Pt 2): 423– 428. 11931151
  49. [55]Goldstein EJ, Citron DM, Peraino VA, Cross SA. Desulfovibrio desulfuricans bacteremia and review of human Desulfovibrio infections. J Clin Microbiol 2003; 41: 2752– 2754. 12791922 PMC156571
  50. [56]Chen YR, Jing QL, Chen FL, Zheng H, Chen LD, Yang ZC. Desulfovibrio is not always associated with adverse health effects in the Guangdong Gut Microbiome Project. PeerJ 2021; 9: e12033. 34466295 PMC8380029
  51. [58]Morotomi M, Nagai F, Sakon H, Tanaka R. Paraprevotella clara gen. nov., sp. nov. and Paraprevotella xylaniphila sp. nov., members of the family ‘Prevotellaceae’ isolated from human faeces. Int J Syst Evol Microbiol 2009; 59 (Pt 8): 1895– 1900. 19567577
  52. [59]Seo B, Yoo JE, Lee YM, Ko G. Sellimonas intestinalis gen. nov., sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 2016; 66: 951– 956. 26637816
  53. [60]Muñoz M, Guerrero-Araya E, Cortés-Tapia C, Plaza-Garrido A, Lawley TD, Paredes-Sabja D. Comprehensive genome analyses of sellimonas intestinalis, a potential biomarker of homeostasis gut recovery. Microb Genomics 2020; 6: mgen000476. PMC8116674 33206037
  54. [61]Louis P, Flint HJ. Formation of propionate and butyrate by the human colonic microbiota. Environ Microbiol 2017; 19: 29– 41. 27928878
  55. [62]Reider SJ Moosmang S Tragust J Prebiotic effects of partially hydrolyzed guar gum on the composition and function of the human microbiota-results from the PAGODA trial. Nutrients 2020; 12: 1257. 32354152 PMC7281958
  56. [63]Larson G, Falk P, Hoskins LC. Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora. J Biol Chem 1988; 263: 10790– 10798. 3392043
  57. [64]Hoskins LC, Boulding ET, Gerken TA, Harouny VR, Kriaris MS. Mucin glycoprotein degradation by mucin oligosaccharide-degrading strains of human faecal bacteria. Characterisation of saccharide cleavage products and their potential role in nutritional support of larger faecal bacterial populations. Microb Ecol Health Dis 1992; 5: 193– 207.
  58. [66]Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA. Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Mol Autism 2013; 4: 42. 24188502 PMC3828002
  59. [67]Vacca M, Celano G, Calabrese FM, Portincasa P, Gobbetti M, De Angelis M. The controversial role of human gut lachnospiraceae. Microorganisms 2020; 8: 573. 32326636 PMC7232163
  60. [68]Rajilić-Stojanović M Biagi E Heilig HGHJ Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 2011; 141: 1792– 1801. 21820992
  61. [70]Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: the players involved and the roles they play. Gut Microbes 2017; 8: 607– 615. 28696139 PMC5730390
  62. [71]Selwal KK, Selwal MK, Yu Z. Mucolytic bacteria: prevalence in various pathological diseases. World J Microbiol Biotechnol 2021; 37: 176. 34519941
  63. [73]Ueda M, Stickley A, Sueki H, Matsubayashi T. Mental health status of the general population in Japan during the COVID-19 pandemic. Psychiatry Clin Neurosci 2020; 74: 505– 506. 32609413 PMC7361838
  64. [74]Li Y, Shao L, Mou Y, Zhang Y, Ping Y. Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis. Gut Microbes 2021; 13: 1957407. 34520319 PMC8463034
  65. [75]Mortaş H, Bilici S, Karakan T. The circadian disruption of night work alters gut microbiota consistent with elevated risk for future metabolic and gastrointestinal pathology. Chronobiol Int 2020; 37: 1067– 1081. 32602753
  66. [76]Deaver JA, Eum SY, Toborek M. Circadian disruption changes gut microbiome taxa and functional gene composition. Front Microbiol 2018; 9: 737. 29706947 PMC5909328
  67. [78]Inoue R Sakaue Y Kawada Y Dietary supplementation with partially hydrolyzed guar gum helps improve constipation and gut dysbiosis symptoms and behavioral irritability in children with autism spectrum disorder. J Clin Biochem Nutr 2019; 64: 217– 223. 31138955 PMC6529696
  68. [79]Tahara Y Yamazaki M Sukigara H Gut microbiota-derived short chain fatty acids induce circadian clock entrainment in mouse peripheral tissue. Sci Rep 2018; 8: 1395. 29362450 PMC5780501
  69. [80]O' Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 2015; 277: 32– 48. 25078296
  70. [81]Chen Y Wan M Zhong Y Partially hydrolyzed guar gum modulates gut microbiota, regulates the levels of neurotransmitters, and prevents CUMS-induced depressive-like behavior in mice. Mol Nutr Food Res 2021; 65: e2100146. 34125489
  71. [82]Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics improved stool form via changes in the microbiota and short-chain fatty acids in hemodialysis patients. Kobe J Med Sci 2021; 67: E112– E118. 35367997 PMC9673885

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Authors
Abe, A., Morishima, S., Kapoor, M. P., Inoue, R., Tsukahara, T., Naito, Y., & Ozeki, M.
Affiliations
  • Taiyo Kagaku Co., Ltd. (Japan) (JP)
  • Laboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University
  • Institute of Nutrition and Pathology (Japan) (JP)
  • Kyoto Prefectural University of Medicine (JP)
Corresponding author
Abe, Aya
ORCID
Venue
Journal of Clinical Biochemistry and Nutrition
Publisher
The Society for Free Radical Research Japan
Published
2023
Volume
72
Issue
2
Pages
189-197
ISSN
  • 0912-0009 (ISSN-L)
  • 1880-5086
DOI
10.3164/jcbn.22-75
PMC
PMC10017317
OpenAlex
W4315777632
Cited by
24
References
10
Citations by year
2026: 9 · 2025: 4 · 2024: 9 · 2023: 2
FWCI
6.39
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Journal of Clinical Biochemistry and Nutrition (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
partially hydrolyzed guar gum, dietary fiber, constipation, gut microbiota, sleep quality, motivation, quality of life, fecal characteristics, stool frequency, healthy volunteers

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