The gut-brain axis: the missing link in depression

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

Diversity, stability and resilience of the human gut microbiota

Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works

Hay fever, hygiene, and household size.

Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054 · see citing works

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012 · see citing works

Regulation of short-chain fatty acid production

Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works

The Application of Ecological Theory Toward an Understanding of the Human Microbiome

Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437 · see citing works

So depression is an inflammatory disease, but where does the inflammation come from?

Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423 · see citing works

Microbes in Gastrointestinal Health and Disease

Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,388 · see citing works

Assessment of psychotropic-like properties of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in rats and human subjects

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works

Psychobiotics: A novel class of psychotropic

Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287 · see citing works

Consumption of fermented milk product with probiotic modulates brain activity

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156 · see citing works

Microbiota and neurodevelopmental windows: implications for brain disorders

Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works

Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses

O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works

Correlation between the human fecal microbiota and depression

Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · see citing works

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works

The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat

Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works

Therapeutic Potential of Fecal Microbiota Transplantation

Smits, L. P., Bouter, K. E. C., de Vos, W. M., Borody, T. J., & Nieuwdorp, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.058 · Cited by 717 · see citing works

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691 · see citing works

Gut microbiome composition is linked to whole grain-induced immunological improvements

Martínez, I., Lattimer, J. M., Hubach, K. L., Case, J. A., Yang, J., Weber, C. G., Louk, J. A., Rose, D. J., Kyureghian, G., Peterson, D. A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2012.104 · Cited by 614 · see citing works

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612 · see citing works

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works

Beneficial psychological effects of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in healthy human volunteers

Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574 · see citing works

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: microbial endocrinology in the design, and use of probiotics.

Lyte, M. (2011) · BioEssays · doi:10.1002/bies.201100024 · Cited by 549 · see citing works

Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Lucas, K., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8425-7 · Cited by 466 · see citing works

Role of the intestinal microbiome in health and disease: from correlation to causation

de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works

Gut Hormones and Appetite Control

Wren, A., & Bloom, S. R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.048 · Cited by 434 · see citing works

Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders

MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 432 · see citing works

Immune–neural connections: how the immune system’s response to infectious agents influences behavior

McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works

The gut microbiome and diet in psychiatry: focus on depression

Dash, S., Clarke, G., Berk, M., & Jacka, F. N. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000117 · Cited by 369 · see citing works

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis

Rook, G. A. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04133.x · Cited by 332 · see citing works

Effects of intestinal microbiota on anxiety-like behavior

Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Communicative &amp; Integrative Biology · doi:10.4161/cib.15702 · Cited by 311 · see citing works

Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis

Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works

Evaluation of 16S rDNA-Based Community Profiling for Human Microbiome Research

Jumpstart Consortium Human Microbiome Project Data Generation Working Group (2012) · PLoS ONE · doi:10.1371/journal.pone.0039315 · Cited by 297 · see citing works

The impact of nutrition on the human microbiome

Flint, H. J. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00499.x · Cited by 291 · see citing works

Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters

Davey, K. J., O’Mahony, S. M., Schellekens, H., O’Sullivan, O., Bienenstock, J., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2555-2 · Cited by 275 · see citing works

Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273 · see citing works

Coordination of tolerogenic immune responses by the commensal microbiota

Round, J. L., O’Connell, R. M., & Mazmanian, S. K. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.007 · Cited by 260 · see citing works

Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia

Severance, E. G., Gressitt, K. L., Stallings, C. R., Origoni, A. E., Khushalani, S., Leweke, F. M., Dickerson, F. B., & Yolken, R. H. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.018 · Cited by 243 · see citing works

Psychoactive bacteria <i>Lactobacillus rhamnosus</i> (JB-1) elicits rapid frequency facilitation in vagal afferents

Perez-Burgos, A., Wang, B., Mao, Y.-K., Mistry, B., Neufeld, K.-A. M., Bienenstock, J., & Kunze, W. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00128.2012 · Cited by 235 · see citing works

A Clinician's Primer on the Role of the Microbiome in Human Health and Disease

Khanna, S., & Tosh, P. K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.011 · Cited by 231 · see citing works

The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review

Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works

Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation

Lyte, M., Varcoe, J. J., & Bailey, M. T. (1998) · Physiology &amp; Behavior · doi:10.1016/s0031-9384(98)00145-0 · Cited by 218 · see citing works

Effect of Intestinal Microbial Ecology on the Developing Brain

Douglas‐Escobar, M., Elliott, E., & Neu, J. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.497 · Cited by 207 · see citing works

Probiotic Bacteria Induce a ‘Glow of Health’

Levkovich, T., Poutahidis, T., Smillie, C. S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Alm, E. J., & Erdman, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053867 · Cited by 196 · see citing works

American Journal of Gastroenterology Lecture: Intestinal Microbiota and the Role of Fecal Microbiota Transplant (FMT) in Treatment of C. difficile Infection

Brandt, L. J. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.450 · Cited by 171 · see citing works

Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!

Carvalho, F. A., Aitken, J. D., Vijay–Kumar, M., & Gewirtz, A. T. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153330 · Cited by 164 · see citing works

Evidences for vagus nerve in maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats

Wang, X. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i3.540 · Cited by 143 · see citing works

The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric illness

Hornig, M. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32836208de · Cited by 138 · see citing works

Innate immune responses to mycobacteria and the downregulation of atopic responses

Rook, G. A. W., Martinelli, R., & Brunet, L. R. (2003) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200310000-00003 · Cited by 136 · see citing works

Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype

McKernan, D. P., Dennison, U., Gaszner, G., Cryan, J. F., & Dinan, T. G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.37 · Cited by 131 · see citing works

Hygiene and other early childhood influences on the subsequent function of the immune system

Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109 · see citing works

Infection Control in the Multidrug-Resistant Era: Tending the Human Microbiome

Tosh, P. K., & McDonald, L. C. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir899 · Cited by 99 · see citing works

Probiotics in the United States

Vanderhoof, J. A., & Young, R. (2008) · Clinical Infectious Diseases · doi:10.1086/523339 · Cited by 88 · see citing works

Lactobacillus GG has in vitro effects on enhanced interleukin‐10 and interferon‐γ release of mononuclear cells but no in vivo effects in supplemented mothers and their neonates

Kopp, M., Goldstein, M., Dietschek, A., Sofke, J., Heinzmann, A., & Urbanek, R. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02911.x · Cited by 88 · see citing works

The Treatment of Melancholia by the Lactic Acid Bacillus

Phillips, J. G. P. (1910) · Journal of Mental Science · doi:10.1192/bjp.56.234.422 · Cited by 80 · see citing works

The new link between gut–brain axis and neuropsychiatric disorders

Fetissov, S. O., & Déchelotte, P. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834936e7 · Cited by 74 · see citing works

The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway

Maes, M. H. J., Kenis, G., Kubera, M., de Baets, M., Steinbusch, H. W. M., & Bosmans, E. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.008 · Cited by 64 · see citing works

Neurobehavioral Effects of Interferon-α in Patients with Hepatitis-C: Symptom Dimensions and Responsiveness to Paroxetine

McNutt, M. D., Liu, S., Manatunga, A., Royster, E. B., Raison, C. L., Woolwine, B. J., Demetrashvili, M. F., Miller, A. H., & Musselman, D. L. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.330 · Cited by 56 · see citing works

Effects of Brilliant Blue G on Serum Tumor Necrosis Factor-α Levels and Depression-like Behavior in Mice after Lipopolysaccharide Administration

Ma, M., Ren, Q., Zhang, J.-C., & Hashimoto, K. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.1.31 · Cited by 55 · see citing works

Probiotics in the Treatment of Depression: Science or Science Fiction?

Dinan, T. G., & Quigley, E. M. M. (2011) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048674.2011.613766 · Cited by 53 · see citing works

Gut–brain link grabs neuroscientists

Reardon, S. (2014) · Nature · doi:10.1038/515175a · Cited by 52 · see citing works

Microbiota, the immune system, black moods and the brain—melancholia updated

Smythies, L. E., & Smythies, J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00720 · Cited by 33 · see citing works

Gut flora--mechanisms of regulation.

Macpherson, A. J., & Uhr, T. (2002) · PubMed · Cited by 15 · see citing works

Gut-Brain Axis: The Role of Gut Microbiota in the Psychiatric Disorders

Evrensel, A., & Ceylan, M. E. (2015) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.5455/cap.20150128123852 · Cited by 4 · see citing works

Bağirsak Beyin Ekseni: Psikiyatrik Bozukluklarda Bağirsak Mikrobiyotasinin Rolü-Brain Axis: The Role of Gut Microbiota in Psychiatric Disorders

Evrensel, A., & Ceylan, M. E. (2015) · Cited by 2 · see citing works

Untitled work

Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

The Gut Microbiota and Alzheimer’s Disease

Jiang, C., Li, G., Huang, P., Liu, Z., & Zhao, B. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161141 · Cited by 852 · see citing works

Human gut microbiota in health and disease: Unveiling the relationship

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.999001 · Cited by 762 · see citing works

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works

Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials

Huang, R., Wang, K., & Hu, J. (2016) · Nutrients · doi:10.3390/nu8080483 · Cited by 505 · see citing works

Altered Composition of Gut Microbiota in Depression: A Systematic Review

Barandouzi, Z. A., Starkweather, A. R., Henderson, W. A., Gyamfi, A., & Cong, X. S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00541 · Cited by 461 · see citing works

The progress of gut microbiome research related to brain disorders

Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works

Gut microbiome and depression: what we know and what we need to know

Winter, G., Hart, R. A., Charlesworth, R. P. G., & Sharpley, C. F. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0072 · Cited by 394 · see citing works

Recognizing Depression from the Microbiota–Gut–Brain Axis

Liang, S., Wu, X., Hu, X., Wang, T., & Jin, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061592 · Cited by 387 · see citing works

Relationship between the gut microbiome and brain function

Mohajeri, M. H., La Fata, G., Steinert, R. E., & Weber, P. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy009 · Cited by 376 · see citing works

Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics

Yu, M., Jia, H., Zhou, C., Yang, Y., Zhao, Y., Yang, M., & Zou, Z. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.02.008 · Cited by 366 · see citing works

Absolute quantitation of microbiota abundance in environmental samples

Tkacz, A., Hortala, M., & Poole, P. S. (2018) · Microbiome · doi:10.1186/s40168-018-0491-7 · Cited by 328 · see citing works

The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.

Appleton, J. (2018) · Europe PMC (PubMed Central) · Cited by 337 · see citing works

Tryptophan Metabolism by Gut Microbiome and Gut-Brain-Axis: An in silico Analysis

Kaur, H., Bose, C., & Mande, S. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01365 · Cited by 320 · see citing works

Microglia: An Interface between the Loss of Neuroplasticity and Depression

Singhal, G., & Baune, B. T. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00270 · Cited by 252 · see citing works

Impact of Edible Cricket Consumption on Gut Microbiota in Healthy Adults, a Double-blind, Randomized Crossover Trial

Stull, V. J., Finer, E., Bergmans, R. S., Febvre, H. P., Longhurst, C. A., Manter, D. K., Patz, J. A., & Weir, T. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-29032-2 · Cited by 250 · see citing works

Gut microbiota–brain axis in depression: the role of neuroinflammation

Carlessi, A. S., Borba, L. A., Zugno, A. I., Quevedo, J., & Réus, G. Z. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14631 · Cited by 243 · see citing works

Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults

Liu, R. T., Rowan-Nash, A. D., Sheehan, A. E., Walsh, R. F. L., Sanzari, C. M., Korry, B. J., & Belenky, P. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.026 · Cited by 244 · see citing works

Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders

Mitrea, L., Nemeș, S. A., Szabo, K., Teleky, B., & Vodnar, D. C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.813204 · Cited by 242 · see citing works

The function of gut microbiota in immune-related neurological disorders: a review

Sittipo, P., Choi, J., Lee, S., & Lee, Y. K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02510-1 · Cited by 221 · see citing works

Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

Liu, C.-H., Yang, M.-H., Zhang, G.-Z., Wang, X.-X., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01732-5 · Cited by 210 · see citing works

Crosstalk between the microbiota-gut-brain axis and depression

Du, Y., Gao, X.-R., Peng, L., & Ge, J.-F. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04097 · Cited by 191 · see citing works

Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder with current major depressive episode patients

Rong, H., Xie, X., Zhao, J., Lai, W., Wang, M., Xu, D., Liu, Y., Guo, Y., Xu, S., Deng, W.-F., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.03.017 · Cited by 185 · see citing works

Leaky gut biomarkers in depression and suicidal behavior

Ohlsson, L., Gustafsson, A., Lavant, E. H., Suneson, K., Brundin, L., Westrin, Å., Ljunggren, L., & Lindqvist, D. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12978 · Cited by 181 · see citing works

Impact of dietary fats on brain functions

Chianese, R., Coccurello, R., Viggiano, A., Scafuro, M., Fiore, M., Coppola, G., Operto, F. F., Fasano, S., Laye, S., Pierantoni, R., et al. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171017102547 · Cited by 159 · see citing works

Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis

Sun, J., Wang, F., Hu, X., Yang, C., Xu, H., Yao, Y., & Liu, J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02462 · Cited by 158 · see citing works

PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial

Reininghaus, E. Z., Platzer, M., Kohlhammer-Dohr, A., Hamm, C., Mörkl, S., Bengesser, S., Fellendorf, F. T., Lahousen-Luxenberger, T., Leitner-Afschar, B., Schöggl, H., et al. (2020) · Nutrients · doi:10.3390/nu12113422 · Cited by 158 · see citing works

Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

Ma, T., Jin, H., Kwok, L., Sun, Z., Liong, M., & Zhang, H. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100294 · Cited by 153 · see citing works

Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders

Evrensel, A., & Ceylan, M. E. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.3.231 · Cited by 150 · see citing works

Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation

Dutta, S., Verma, S., Jain, V., Surapaneni, B. K., Vinayek, R., Phillips, L. E., & Nair, P. P. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19044 · Cited by 149 · see citing works

Human Gut Microbiota: Toward an Ecology of Disease

Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 145 · see citing works

Gut microbiota in various childhood disorders: Implication and indications

Saeed, N. K., Al‐Beltagi, M., Bediwy, A. S., El-Sawaf, Y., & Toema, O. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i18.1875 · Cited by 147 · see citing works

The Microbiota-Inflammasome Hypothesis of Major Depression

Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134 · see citing works

Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry

Kawashima, Y., Nagai, H., Konno, R., Ishikawa, M., Nakajima, D., Sato, H., Nakamura, R., Furuyashiki, T., & Ohara, O. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00023 · Cited by 125 · see citing works

Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress

Li, J., Xueyang, J., Cui, W., Wu, C., & Xue-mei, Q. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0391-z · Cited by 129 · see citing works

The Therapeutic Potential of Plant Polysaccharides in Metabolic Diseases

Wang, X.-F., Chen, X., Tang, Y.-F., Wu, J.-M., Qin, D.-L., Yu, L., Yu, C.-L., Zhou, X.-G., & Wu, A.-G. (2022) · Pharmaceuticals · doi:10.3390/ph15111329 · Cited by 117 · see citing works

Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin

Zhao, Z., Fu, J., Ma, S., Peng, R., Yu, J., Lin, C., Pan, L., Zhang, Z., Tian, H., Che, C., et al. (2018) · Theranostics · doi:10.7150/thno.28068 · Cited by 126 · see citing works

The Role of Nutrition and the Gut-Brain Axis in Psychiatry: A Review of the Literature

Mörkl, S., Wagner‐Skacel, J., Lahousen, T., Lackner, S., Holasek, S. J., Bengesser, S., Painold, A., Holl, A. K., & Reininghaus, E. Z. (2018) · Neuropsychobiology · doi:10.1159/000492834 · Cited by 129 · see citing works

Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders

Israelyan, N., & Margolis, K. G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.020 · Cited by 122 · see citing works

Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

Guo, Y., Xie, J., Deng, K., Li, X., Yuan, Y., Xuan, Q., Xie, J., He, X.-M., Wang, Q., Li, J., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00126 · Cited by 122 · see citing works

Gut microbiota composition is associated with newborn functional brain connectivity and behavioral temperament

Kelsey, C. M., Prescott, S., McCulloch, J. A., Trinchieri, G., Valladares, T. L., Dreisbach, C., Alhusen, J., & Grossmann, T. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.003 · Cited by 116 · see citing works

The role of the gut-brain axis in depression: endocrine, neural, and immune pathways

Makris, A. P., Karianaki, M., Tsamis, K. I., & Paschou, S. Α. (2020) · HORMONES · doi:10.1007/s42000-020-00236-4 · Cited by 120 · see citing works

Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome

Barandouzi, Z. A., Lee, J., Rosas, M. D. C., Chen, J., Henderson, W. A., Starkweather, A. R., & Cong, X. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-05756-0 · Cited by 117 · see citing works

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease

Kaur, H., Nagamoto‐Combs, K., Golovko, S. A., Golovko, M. Y., Klug, M. G., & Combs, C. K. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.009 · Cited by 112 · see citing works

Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice

Medina-Rodriguez, E. M., Madorma, D., O’Connor, G., Mason, B. L., Han, D., Deo, S. K., Oppenheimer, M., Nemeroff, C. B., Trivedi, M. H., Daunert, S., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19090960 · Cited by 110 · see citing works

Alleviation of depression by glucagon-like peptide 1 through the regulation of Neuroinflammation, neurotransmitters, neurogenesis, and synaptic function

Kim, Y.-K., Kim, O. Y., & Song, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01270 · Cited by 109 · see citing works

Effects of long-term administration of Multi-Strain Probiotic on circulating levels of BDNF, NGF, IL-6 and mental health in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial

Rahimlou, M., Hosseini, S. A., Majdinasab, N., Haghighizadeh, M. H., & Husain, D. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1758887 · Cited by 108 · see citing works

Maternal gut and fetal brain connection: Increased anxiety and reduced social interactions in Wistar rat offspring following peri-conceptional antibiotic exposure

Degroote, S., Hunting, D. J., Baccarelli, A. A., & Takser, L. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.010 · Cited by 106 · see citing works

The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights

Marano, G., Mazza, M., Lisci, F. M., Ciliberto, M., Traversi, G., Kotzalidis, G. D., Berardis, D. D., Laterza, L., Sani, G., Gasbarrini, A., et al. (2023) · Nutrients · doi:10.3390/nu15061496 · Cited by 109 · see citing works

Variations in the oral microbiome are associated with depression in young adults

Wingfield, B., Lapsley, C. R., McDowell, A., Miliotis, G., McLafferty, M., O’Neill, S. M., Coleman, S., McGinnity, T. M., Bjourson, A. J., & Murray, E. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-94498-6 · Cited by 103 · see citing works

Sodium butyrate triggers a functional elongation of microglial process via akt-small RhoGTPase activation and HDACs inhibition

Wang, P., Zhang, Y., Gong, Y., Yang, R., Chen, Z., Hu, W., Wu, Y., Gao, M., Xu, X., Qin, Y., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.006 · Cited by 97 · see citing works

Can psychobiotics “mood” ify gut? An update systematic review of randomized controlled trials in healthy and clinical subjects, on anti-depressant effects of probiotics, prebiotics, and synbiotics

Vaghef‐Mehrabany, E., Maleki, V., Behrooz, M., Ranjbar, F., & Ebrahimi‐Mameghani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.06.004 · Cited by 95 · see citing works

The gut microbiome correlates with conspecific aggression in a small population of rescued dogs(Canis familiaris)

Kirchoff, N. S., Udell, M. A. R., & Sharpton, T. J. (2019) · PeerJ · doi:10.7717/peerj.6103 · Cited by 88 · see citing works

Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders

Israelyan, N., & Margolis, K. G. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.023 · Cited by 87 · see citing works

The mechanism of electroacupuncture for depression on basic research: a systematic review

Han, X., Gao, Y., Yin, X., Zhang, Z., Lao, L., Chen, Q., & Xu, S. (2021) · Chinese Medicine · doi:10.1186/s13020-020-00421-y · Cited by 87 · see citing works

Bacteriome Structure, Function, and Probiotics in Fish Larviculture: The Good, the Bad, and the Gaps

Borges, N., Keller‐Costa, T., Sanches‐Fernandes, G. M. M., Louvado, A., Gomes, N. C. M., & Costa, R. (2020) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-062920-113114 · Cited by 84 · see citing works

Microbiome and metabolome data integration provides insight into health and disease

Shaffer, M., Armstrong, A. J. S., Phelan, V. V., Reisdorph, N. A., & Lozupone, C. (2017) · Translational research · doi:10.1016/j.trsl.2017.07.001 · Cited by 85 · see citing works

Gut-brain axis: A matter of concern in neuropsychiatric disorders…!

Naveed, M., Zhou, Q.-G., Chu, X., Taleb, A., Meng, F. J., Ahmed, B., Zhang, Y., Fukunaga, K., & Han, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110051 · Cited by 81 · see citing works

Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion

Chang‐Graham, A. L., Danhof, H. A., Engevik, M. A., Tomaro-Duchesneau, C., Karandikar, U. C., Estes, M. K., Versalovic, J. A., Britton, R. A., & Hyser, J. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.010 · Cited by 79 · see citing works

The Human Gut Microbiome in Health and Disease

Jovel, J., Dieleman, L. A., Kao, D. H., Mason, A. L., & Wine, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-102268-9.00010-0 · Cited by 78 · see citing works

A Gut-Brain Axis-on-a-Chip for studying transport across epithelial and endothelial barriers

Kim, M., Kim, D., & Sung, J. H. (2021) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2021.06.021 · Cited by 77 · see citing works

Effect of combined chronic predictable and unpredictable stress on depression-like symptoms in mice

Qiao, Y., Zhao, J., Li, C., Zhang, M., Wei, L., Zhang, X., Kurskaia, O. V., Bi, H., & Gao, T. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-5168 · Cited by 76 · see citing works

Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats

Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75 · see citing works

Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Khalil, M., Ciaula, A. D., Mahdi, L., Jaber, N., Palo, D. M. D., Graziani, A., Baffy, G., & Portincasa, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112333 · Cited by 98 · see citing works

Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis

Ranuh, R. G., Athiyyah, A. F., Darma, A., Risky, V. P., Riawan, W., SURONO, I. S., & Sudarmo, S. M. (2019) · Iranian Journal of Microbiology · doi:10.18502/ijm.v11i2.1077 · Cited by 74 · see citing works

Correction: Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress

Li, J., Xueyang, J., Cui, W., Wu, C., & Xue-mei, Q. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0645-9 · Cited by 72 · see citing works

New Insights Into the Comorbidity of Coronary Heart Disease and Depression

Wu, Y., Zhu, B., Chen, Z., Duan, J., Luo, A., Yang, L., & Yang, C. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.002 · Cited by 70 · see citing works

The role of the brain–gut–microbiota axis in psychology: The importance of considering gut microbiota in the development, perpetuation, and treatment of psychological disorders

Ganci, M., Suleyman, E., Butt, H., & Ball, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1408 · Cited by 71 · see citing works

Dairy probiotics: Beyond the role of promoting gut and immune health

Ζουμποπούλου, Γ., Pot, B., Tsakalidou, E., & Papadimitriou, K. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.09.010 · Cited by 70 · see citing works

Neuroinflammation, Gut-Brain Axis and Depression

Evrensel, A., Ünsalver, B. Ö., & Ceylan, M. E. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.08.09 · Cited by 71 · see citing works

Targeting the Microbiota in Pharmacology of Psychiatric Disorders

Pascale, A., Marchesi, N., Govoni, S., & Barbieri, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104856 · Cited by 67 · see citing works

Interpersonal Variations in Gut Microbiota Profiles Supersedes the Effects of Differing Fecal Storage Conditions

Bundgaard‐Nielsen, C., Hagstrøm, S., & Sørensen, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35843-0 · Cited by 65 · see citing works

Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

Zyoud, S. H., Smale, S., Waring, W. S., Sweileh, W. M., & Al‐Jabi, S. W. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-1076-z · Cited by 68 · see citing works

The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder

Dam, S. A., Mostert, J. C., Szopinska-Tokov, J., Bloemendaal, M., Amato, M. P., & Vásquez, A. A. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.05.001 · Cited by 63 · see citing works

Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice

Qiu, X., Wu, G., Wang, L., Tan, Y., & Song, Z. Q. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4411 · Cited by 63 · see citing works

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

Newberry, F., Hsieh, S.-Y., Wileman, T., & Carding, S. R. (2018) · Clinical Science · doi:10.1042/cs20171330 · Cited by 61 · see citing works

Effect of probiotic interventions on depressive symptoms: A narrative review evaluating systematic reviews

Ibrahim, N., Rahman, M. Z., Ad-Dab’bagh, Y., & Akhtar, M. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12804 · Cited by 62 · see citing works

Major Depressive Disorder and gut microbiota – Association not causation. A scoping review

Łoniewski, I., Misera, A., Skonieczna‐Żydecka, K., Kaczmarczyk, M., Kaźmierczak-Siedlecka, K., Misiak, B., Marlicz, W. M., & Samochowiec, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110111 · Cited by 63 · see citing works

A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective

Rawat, K., Singh, N., Kumari, P., & Saha, L. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0078 · Cited by 58 · see citing works

Role of gut microbiota in depression: Understanding molecular pathways, recent research, and future direction

Rathour, D., Shah, S., Khan, S., Singh, P. K., Srivastava, S., Singh, S. B., & Khatri, D. K. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114081 · Cited by 56 · see citing works

Relationship between diet, the gut microbiota, and brain function

Tengeler, A. C., Kozicz, T., & Kiliaan, A. J. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy016 · Cited by 57 · see citing works

Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling

Ceppa, F., Izzo, L., Sardelli, L., Raimondi, I., Tunesi, M., Albani, D., & Giordano, C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00297 · Cited by 57 · see citing works

Interactions Between Antidepressants and Intestinal Microbiota

Xu, F., Xie, Q., Kuang, W., & Dong, Z. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01362-8 · Cited by 58 · see citing works

Effect of probiotic administration on gut microbiota and depressive behaviors in mice

Liu, Q. F., Kim, H.-M., Lim, S., Chung, M.-J., Lim, C., Koo, B., & Kang, S. (2020) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-020-00329-w · Cited by 54 · see citing works

Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry

Lozupone, M., Seripa, D., Stella, E., Montagna, M. L., Solfrizzi, V., Quaranta, N. A. A., Veneziani, F., Cester, A., Sardone, R., Bonfiglio, C., et al. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1375857 · Cited by 51 · see citing works

Remitted affective disorders and high familial risk of affective disorders associate with aberrant intestinal microbiota

Vinberg, M., Ottesen, N. M., Meluken, I., Sørensen, N., Pedersen, O. B., Kessing, L. V., & Miskowiak, K. W. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12976 · Cited by 51 · see citing works

Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression

Khadrawy, Y. A., Hosny, E. N., Magdy, M., & Mohammed, H. S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174384 · Cited by 51 · see citing works

Tryptophan and Its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain–Gut–Microbiome Axis: A Focus on Sex Differences

Xu, M., Zhou, E. Y., & Shi, H. (2025) · Cells · doi:10.3390/cells14050384 · Cited by 55 · see citing works

Gut Biofactory—Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review

Skonieczna‐Żydecka, K., Jakubczyk, K., Maciejewska, D., Janda, K., Kaźmierczak-Siedlecka, K., Kaczmarczyk, M., Łoniewski, I., & Marlicz, W. M. (2020) · Nutrients · doi:10.3390/nu12113369 · Cited by 50 · see citing works

The role of the gut microbiota in schizophrenia: Current and future perspectives

Rodrígues-Amorím, D., Baltanás, T. R., Regueiro, B. J., Spuch, C., Heras, M. E. D. L., Méndez, R. V.-N., Nieto-Araujo, M., Barreiro-Villar, C., Olivares, J. M., & Agís‐Balboa, R. C. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1433878 · Cited by 47 · see citing works

The Molecular Gut-Brain Axis in Early Brain Development

Muhammad, F., Fan, B., Wang, R., Ren, J., Jia, S., Wang, L., Chen, Z., & Liu, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315389 · Cited by 47 · see citing works

Major depressive disorder and anxiety disorders from the glial perspective: Etiological mechanisms, intervention and monitoring

Sild, M., Ruthazer, E. S., & Booij, L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.014 · Cited by 46 · see citing works

Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats

Huang, L., Lv, X., Ze, X., Ma, Z., Zhang, X., He, R., Fan, J., Zhang, M., Sun, B., Wang, F., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.990465 · Cited by 46 · see citing works

SARS CoV-2 Organotropism Associated Pathogenic Relationship of Gut-Brain Axis and Illness

Shinu, P., Morsy, M. A., Deb, P. K., Nair, A. B., Goyal, M., Jigar, S., & Kotta, S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.606779 · Cited by 45 · see citing works

The association study of chemical compositions and their pharmacological effects of Cyperi Rhizoma (Xiangfu), a potential traditional Chinese medicine for treating depression

Lu, J., Li, W., Gao, T., Wang, S., Fu, C., & Wang, S. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114962 · Cited by 44 · see citing works

Intake of High-Fat Yogurt, but Not of Low-Fat Yogurt or Prebiotics, Is Related to Lower Risk of Depression in Women of the SUN Cohort Study

Perez‐Cornago, A., Sánchez‐Villegas, A., Bes‐Rastrollo, M., Gea, A., Molero, P., Lahortiga‐Ramos, F., & Martínez‐González, M. Á. (2016) · Journal of Nutrition · doi:10.3945/jn.116.233858 · Cited by 44 · see citing works

Immune mechanisms of stress susceptibility and resilience: Lessons from animal models

Tsyglakova, M., McDaniel, D. K., & Hodes, G. E. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100771 · Cited by 44 · see citing works

The Many Faces of Microbiota-Gut-Brain Axis in Autism Spectrum Disorder

Gonçalves, C. L., Doifode, T., Rezende, V. L., Costa, M. A., Rhoads, J. M., & Soutullo, C. A. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122357 · Cited by 42 · see citing works

Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with Phenylketonuria (PKU): A Review

Verduci, E., Carbone, M. T., Borghi, E., Ottaviano, E., Burlina, A., & Biasucci, G. (2020) · Nutrients · doi:10.3390/nu12113319 · Cited by 41 · see citing works

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The Gut-Brain Axis: The Missing Link in Depression

Evrensel, A., & Ceylan, M. E. (2015)

Gut-Brain Axis: The Role of Gut Microbiota in the Psychiatric Disorders

Evrensel, A., & Ceylan, M. E. (2015) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.5455/cap.20150128123852 · Cited by 4 · see citing works

Therapeutic role and importance of gut microbiota in brain and related disorder: A review

Kundu Smita, S., & Rana, D. G. (2021) · Asian Journal of Pharmacy and Pharmacology · doi:10.31024/ajpp.2021.7.1.6

The Microbiota-Gut-Brain Axis: A New Direction in Research on Depression

Chen, E., & Clark, R. E. (2021) · Journal of Student Research · doi:10.47611/jsrhs.v10i2.1504 · Cited by 3 · see citing works

The Role of Gut Microbiota in the Development of Depression: A Review

Brożyna, A., Mackiewicz, A., Pietrucień, A., Kursa, N., Bielak, K., Woźniak, K., Witkowska, J., Jakubiak, K., Kurczyński, M., & Krasoń, M. (2026) · Medical Science · doi:10.54905/disssi.v30i171.e93ms3880