Immune and production responses of dairy cows to postruminal supplementation with phytonutrients
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This study investigated the effect of phytonutrients (PN) supplied postruminally on nutrient utilization, gut microbial ecology, immune response, and productivity of lactating dairy cows. Eight ruminally cannulated Holstein cows were used in a replicated 4×4 Latin square. Experimental periods lasted 23 d, including 14-d washout and 9-d treatment periods. Treatments were control (no PN) and daily doses of 2g/cow of either curcuma oleoresin (curcumin), garlic extract (garlic), or capsicum oleoresin (capsicum). Phytonutrients were pulse-dosed into the abomasum of the cows, through the rumen cannula, 2 h after feeding during the last 9 d of each experimental period. Dry matter intake was not affected by PN, although it tended to be lower for the garlic treatment compared with the control. Milk yield was decreased (2.2 kg/d) by capsicum treatment compared with the control. Feed efficiency, milk composition, milk fat and protein yields, milk N efficiency, and 4.0% fat-corrected milk yield were not affected by treatment. Rumen fermentation variables, apparent total-tract digestibility of nutrients, N excretion with feces and urine, and diversity of fecal bacteria were also not affected by treatment. Phytonutrients had no effect on blood chemistry, but the relative proportion of lymphocytes was increased by the capsicum treatment compared with the control. All PN increased the proportion of total CD4(+) cells and total CD4(+) cells that co-expressed the activation status signal and CD25 in blood. The percentage of peripheral blood mononuclear cells (PBMC) that proliferated in response to concanavalin A and viability of PBMC were not affected by treatment. Cytokine production by PBMC was not different between control and PN. Expression of mRNA in liver for key enzymes in gluconeogenesis, fatty acid oxidation, and response to reactive oxygen species were not affected by treatment. No difference was observed due to treatment in the oxygen radical absorbance capacity of blood plasma but, compared with the control, garlic treatment increased 8-isoprostane levels. Overall, the PN used in this study had subtle or no effects on blood cells and blood chemistry, nutrient digestibility, and fecal bacterial diversity, but appeared to have an immune-stimulatory effect by activating and inducing the expansion of CD4 cells in dairy cows. Capsicum treatment decreased milk yield, but this and other effects observed in this study should be interpreted with caution because of the short duration of treatment.
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Plant secondary metabolites have shown significant manipulation of the rumen microflora leading to a shift in fermentation dynamics and milk production in lactating animals.
“Despite the sustainability of functional redundancy in the rumen microbiome, plant secondary metabolites have shown significant manipulation of the rumen microflora leading to a shift in fermentation dynamics and milk production in lactating animals (29, 31, 145–147).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [146]
The Results (page unavailable) report that phytonutrient treatment did not affect rumen fermentation variables or fecal bacteria. The Discussion (page unavailable) says these compounds were administered postruminally, bypassing rumen metabolism, and describes limited or no milk-production effects in prior studies of plant extracts as rumen modifiers. This paper therefore does not show the claimed chain from rumen-microflora manipulation to changed fermentation and milk production. (LLM, conf=0.88)
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- Authors
- Oh, J., Hristov, A. N., Lee, C., Cassidy, T., Heyler, K., Varga, G. A., Pate, J., Walusimbi, S., Brzezicka, E., Toyokawa, K., Werner, J., Donkin, S. S., Elias, R., Dowd, S., & Bravo, D.
- Affiliations
- Pennsylvania State University (US)
- Purdue University West Lafayette (US)
- Corresponding author
- Hristov, A.N.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2013-12
- Volume
- 96
- Issue
- 12
- Pages
- 7830-7843
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W2094539980
- Cited by
- 89
- References
- 77
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 2
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Pennsylvania State University
- Topics
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Ruminant Nutrition and Digestive Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Keywords
- phytochemicals, dairy cattle, lactating dairy cows, curcumin, garlic extract, capsicum oleoresin, immune response, CD4+ T cells, lymphocyte proliferation, milk yield, milk composition, nutrient digestibility, rumen fermentation, 8-isoprostane, oxidative stress, hepatic gene expression, feed efficiency
- MeSH terms
- Abomasum, Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Capsicum, Cattle, Curcumin, Diet, Feces, Female, Fermentation, Garlic, Lactation, Milk, Rumen, Dietary Supplements
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