Cited by 718Protein Hydrolysis and Bioactive PeptidesProteins in Food SystemsAntimicrobial Peptides and Activities

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Bioactive milk peptides: a prospectus.

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Clare, D.A., Swaisgood, H.E.·2000·Journal of Dairy Science

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Abstract

Bioactive peptides have been identified within the amino acid sequences of native milk proteins. Hydrolytic reactions, such as those catalyzed by digestive enzymes, result in their release. These peptides directly influence numerous biological processes evoking behavioral, gastrointestinal, hormonal, immunological, neurological, and nutritional responses. The specific bioreactions associated with each physiological class have been well characterized. Herein, we review the scientific literature and attempt to stimulate consideration of the continued use of bioactive peptides and their expanded development as a commercial product. Several applications have already evolved. For example, phosphopeptides derived from casein fractions are currently used as both dietary and pharmaceutical supplements. Potentially, the addition of bioactive peptides to food products could improve consumer safety as a result of their antimicrobial properties. Lastly, bioactive peptides may function as health care products, providing therapeutic value for either treatment of infection or prevention of disease.

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Identification of the bactericidal domain of lactoferrin
Bellamy, W., Takase, M., Yamauchi, K., Wakabayashi, H., Kawase, K., & TOMITA, M. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90346-f · Cited by 890
Purification and Characterization of Angiotensin I-Converting Enzyme Inhibitors from Sour Milk
Nakamura, Y., Yamamoto, N., Sakai, K., Ōkubo, A., Yamazaki, S., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76689-9 · Cited by 838
Iron-binding Proteins in Milk and Resistance to Escherichia coli Infection in Infants
Bullen, J. J., Rogers, H. J., & Leigh, L. C. (1972) · BMJ · doi:10.1136/bmj.1.5792.69 · Cited by 651
Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N ‐terminal region of bovine lactoferrin
Bellamy, W., Takase, M., Wakabayashi, H., Kawase, K., & TOMITA, M. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb05007.x · Cited by 588
Antihypertensive Effect of Sour Milk and Peptides Isolated from It That are Inhibitors to Angiotensin I-Converting Enzyme
Nakamura, Y., Yamamoto, N., Sakai, K., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76745-5 · Cited by 556
Potent Antibacterial Peptides Generated by Pepsin Digestion of Bovine Lactoferrin
TOMITA, M., Bellamy, W., Takase, M., Yamauchi, K., Wakabayashi, H., & Kawase, K. (1991) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(91)78608-6 · Cited by 445
Novel Opioid Peptides Derived from Casein (β-Casomorphins). I. Isolation from Bovine Casein Peptone
Brantl, V., Teschemacher, H., Henschen, A., & Lottspeich, F. (1979) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1979.360.2.1211 · Cited by 420
Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790
Yamamoto, N., Akino, A., & Takano, T. (1994) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(94)77026-0 · Cited by 418
Identification of an Antihypertensive Peptide from Casein Hydrolysate Produced by a Proteinase from Lactobacillus helveticus CP790
Maeno, M., Yamamoto, N., & Takano, T. (1996) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(96)76487-1 · Cited by 392
Opioid peptides derived from food proteins. The exorphins
Zioudrou, C., Streaty, R. A., & Klee, W. A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30243-0 · Cited by 373

Show all 99 references

Research works printed but not linked: 8

Kohmura, 1990, Inhibition of angiotensin I-converting enzyme by synthetic peptides of human κ-casein, Agric. Biol. Chem., 54, 835
Lahov, 1971, Properties of basic glycopeptides from cow milk protein by heat, Milchwissenschaft, 26, 489
Mullally, 1996, Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotension-I-converting enzyme inhibitory activity, Biol. Chem. Hoppe Seyler, 377, 259
Nieter, 1981, Insulotropic actions of endorphins and β-casomorphin, an opioid-like fragment of milk casein, Diabetologia, 21, 309
Schlimme, 1993, Bioactive peptides: structural, physiological, and analytical aspects, Newsletter of the Int. Dairy Fed., 139
Sturner, 1988, Opioid peptide content in infant formulas, Pediatr. Res., 23, 4
Teschemacher, 1994, Milk proteinderived atypical peptides and related compounds with opioid antagonist activity (review), 3
Yamamoto, 1997, Antihypertensive peptides derived from food proteins, Biopolymers, 43, 129, 10.1002/(SICI)1097-0282(1997)43:2<129::AID-BIP5>3.0.CO;2-X · DOI

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Functional properties and biological activities of bovine casein proteins and peptides.
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Impact of transglutaminase reaction on the immunoreactive and sensory quality of yoghurt starter
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Health-promoting properties of selected milk components
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Effect of extrusion process on antioxidant and ACE inhibition properties from bovine haemoglobin concentrate hydrolysates incorporated into expanded maize products
Cian, R. E., Luggren, P. J., & Drago, S. R. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.582034 · Cited by 21
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Membrane-Based Fractionation and Purification Strategies for Bioactive Peptides
Mine, Y., & Shahidi, F. (2005) · doi:10.1201/9781420028836-36 · Cited by 21
Dried cell-free fraction of fermented milks: new functional additives for the food industry
Vinderola, G. (2007) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2007.07.003 · Cited by 21
Biochemical Properties of Recombinant Leucine Aminopeptidase II from Bacillus stearothermophilus and Potential Applications in the Hydrolysis of Chinese Anchovy (Engraulis japonicus) Proteins
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RETRACTED: In silico proteolysis and molecular interaction of tilapia (Oreochromis niloticus) skin collagen-derived peptides for environmental remediation
Munawaroh, H. S. H., Gumilar, G. G., Berliana, J. D., Aisyah, S., Nuraini, V. A., Ningrum, A., Susanto, E., Martha, L., Kurniawan, I., Hidayati, N. A., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113002 · Cited by 20
Retracted
Milk protein hydrolysates activate 5-HT2C serotonin receptors: influence of the starting substrate and isolation of bioactive fractions
Nongonierma, A. B., Schellekens, H., Dinan, T. G., Cryan, J. F., & Fitzgerald, R. J. (2013) · Food & Function · doi:10.1039/c3fo30309h · Cited by 20
Kinetics of IFN-γ producing CHO cells and other industrially relevant cell lines in rapeseed-supplemented batch cultures
Farges, B., Chenu, S., Marc, A., & Goergen, J. L. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.04.025 · Cited by 20

Authors: Clare, D. A., & Swaisgood, H. E.
Affiliations: North Carolina State University (US)
Venue: Journal of Dairy Science
Publisher: American Dairy Science Association
Published: 2000-06
Volume: 83
Issue: 6
Pages: 1187-1195
ISSN: 0022-0302 (ISSN-L)
DOI: 10.3168/jds.s0022-0302(00)74983-6
OpenAlex: W2117071648
Cited by: 718
References: 99
Citations by year: 2026: 11 · 2025: 9 · 2024: 12 · 2023: 16 · 2022: 24 · 2021: 28 · 2020: 22 · 2019: 20 · 2018: 32 · 2017: 33 · 2016: 30 · 2015: 39 · 2014: 52 · 2013: 38 · 2012: 43
FWCI: 0.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6801 d)
Locations: Journal of Dairy Science (publishedVersion)
PubMed (publishedVersion)
Funders: North Carolina State University
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: bioactive peptides, milk protein, casein hydrolysate, phosphopeptides, dietary supplements, antimicrobial peptides, functional foods, health products
MeSH terms: Angiotensin-Converting Enzyme Inhibitors, Animals, Cattle, Fibrinolytic Agents, Milk, Milk Proteins, Peptides, Opioid Peptides

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