Cited by 718Protein Hydrolysis and Bioactive PeptidesProteins in Food SystemsAntimicrobial Peptides and Activities

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Bioactive milk peptides: a prospectus.

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Clare, D.A., Swaisgood, H.E.·2000·Journal of Dairy Science

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Abstract

Bioactive peptides have been identified within the amino acid sequences of native milk proteins. Hydrolytic reactions, such as those catalyzed by digestive enzymes, result in their release. These peptides directly influence numerous biological processes evoking behavioral, gastrointestinal, hormonal, immunological, neurological, and nutritional responses. The specific bioreactions associated with each physiological class have been well characterized. Herein, we review the scientific literature and attempt to stimulate consideration of the continued use of bioactive peptides and their expanded development as a commercial product. Several applications have already evolved. For example, phosphopeptides derived from casein fractions are currently used as both dietary and pharmaceutical supplements. Potentially, the addition of bioactive peptides to food products could improve consumer safety as a result of their antimicrobial properties. Lastly, bioactive peptides may function as health care products, providing therapeutic value for either treatment of infection or prevention of disease.

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Authors: Clare, D. A., & Swaisgood, H. E.
Affiliations: North Carolina State University (US)
Venue: Journal of Dairy Science
Publisher: American Dairy Science Association
Published: 2000-06
Volume: 83
Issue: 6
Pages: 1187-1195
ISSN: 0022-0302 (ISSN-L)
DOI: 10.3168/jds.s0022-0302(00)74983-6
OpenAlex: W2117071648
Cited by: 718
References: 99
Citations by year: 2026: 11 · 2025: 9 · 2024: 12 · 2023: 16 · 2022: 24 · 2021: 28 · 2020: 22 · 2019: 20 · 2018: 32 · 2017: 33 · 2016: 30 · 2015: 39 · 2014: 52 · 2013: 38 · 2012: 43
FWCI: 0.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6801 d)
Locations: Journal of Dairy Science (publishedVersion)
PubMed (publishedVersion)
Funders: North Carolina State University
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords: bioactive peptides, milk protein, casein hydrolysate, phosphopeptides, dietary supplements, antimicrobial peptides, functional foods, health products
MeSH terms: Angiotensin-Converting Enzyme Inhibitors, Animals, Cattle, Fibrinolytic Agents, Milk, Milk Proteins, Peptides, Opioid Peptides

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