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Cited by 718Protein Hydrolysis and Bioactive PeptidesProteins in Food SystemsAntimicrobial Peptides and Activities

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Bioactive milk peptides: a prospectus.

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Clare, D.A., Swaisgood, H.E.·2000·Journal of Dairy Science
DOI 10.3168/jds.s0022-0302(00)74983-6
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Abstract

Bioactive peptides have been identified within the amino acid sequences of native milk proteins. Hydrolytic reactions, such as those catalyzed by digestive enzymes, result in their release. These peptides directly influence numerous biological processes evoking behavioral, gastrointestinal, hormonal, immunological, neurological, and nutritional responses. The specific bioreactions associated with each physiological class have been well characterized. Herein, we review the scientific literature and attempt to stimulate consideration of the continued use of bioactive peptides and their expanded development as a commercial product. Several applications have already evolved. For example, phosphopeptides derived from casein fractions are currently used as both dietary and pharmaceutical supplements. Potentially, the addition of bioactive peptides to food products could improve consumer safety as a result of their antimicrobial properties. Lastly, bioactive peptides may function as health care products, providing therapeutic value for either treatment of infection or prevention of disease.

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Show all 99 references

Research works printed but not linked: 8

  1. Kohmura, 1990, Inhibition of angiotensin I-converting enzyme by synthetic peptides of human κ-casein, Agric. Biol. Chem., 54, 835
  2. Lahov, 1971, Properties of basic glycopeptides from cow milk protein by heat, Milchwissenschaft, 26, 489
  3. Mullally, 1996, Synthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotension-I-converting enzyme inhibitory activity, Biol. Chem. Hoppe Seyler, 377, 259
  4. Nieter, 1981, Insulotropic actions of endorphins and β-casomorphin, an opioid-like fragment of milk casein, Diabetologia, 21, 309
  5. Schlimme, 1993, Bioactive peptides: structural, physiological, and analytical aspects, Newsletter of the Int. Dairy Fed., 139
  6. Sturner, 1988, Opioid peptide content in infant formulas, Pediatr. Res., 23, 4
  7. Teschemacher, 1994, Milk proteinderived atypical peptides and related compounds with opioid antagonist activity (review), 3
  8. Yamamoto, 1997, Antihypertensive peptides derived from food proteins, Biopolymers, 43, 129, 10.1002/(SICI)1097-0282(1997)43:2<129::AID-BIP5>3.0.CO;2-X · DOI

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Metadata

Authors
Clare, D. A., & Swaisgood, H. E.
Affiliations
North Carolina State University (US)
Venue
Journal of Dairy Science
Publisher
American Dairy Science Association
Published
2000-06
Volume
83
Issue
6
Pages
1187-1195
ISSN
0022-0302 (ISSN-L)
DOI
10.3168/jds.s0022-0302(00)74983-6
OpenAlex
W2117071648
Cited by
718
References
99
Citations by year
2026: 11 · 2025: 9 · 2024: 12 · 2023: 16 · 2022: 24 · 2021: 28 · 2020: 22 · 2019: 20 · 2018: 32 · 2017: 33 · 2016: 30 · 2015: 39 · 2014: 52 · 2013: 38 · 2012: 43
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Dairy Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
North Carolina State University
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords
bioactive peptides, milk protein, casein hydrolysate, phosphopeptides, dietary supplements, antimicrobial peptides, functional foods, health products
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Animals, Cattle, Fibrinolytic Agents, Milk, Milk Proteins, Peptides, Opioid Peptides

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