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Cited by 322Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

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Effects of Milk Products Fermented by Bifidobacterium longum on Blood Lipids in Rats and Healthy Adult Male Volunteers

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Xiao, J.Z., Kondo, S., Takahashi, N., Miyaji, K., Oshida, K., Hiramatsu, A., Iwatsuki, K., Kokubo, S., Hosono, A.·2003·Journal of Dairy Science
DOI 10.3168/jds.s0022-0302(03)73839-9
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Abstract

The effects of milk products fermented by Bifidobacterium longum strain BL1, a probiotic strain, on blood lipids in rats and humans were studied. Rats were fed a cholesterol-enriched experimental diet, supplemented with lyophilized powders of 1) acid milk (control), 2) milk fermented with a mixed culture of ordinary yogurt starters composed of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL), and 3) bifidobacterium milk fermented with the probiotic B. longum strain BL1, respectively. The bifidobacterium milk feeding brought about significant lowering of the serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, in comparison with the control, while no change in high-density lipoprotein cholesterol concentration was observed. On the other hand, supplementation with SL milk resulted in only slight, nonsignificant decreases in serum lipid concentrations in comparison with the control. In the human study, 32 subjects with serum total cholesterol ranging from 220 to 280 mg/dl were randomly assigned to two treatments: 1) intake of a low-fat drinking yogurt prepared with ordinary yogurt starters composed of S. thermophilus and L. delbrueckii subsp. bulgaricus (P-group) and 2) intake of a low-fat drinking yogurt prepared with the two ordinary yogurt starters plus B. longum strain BL1 (B-group). After intake for 4 wk at 3 x 100 ml/day, reduction of serum total cholesterol was observed in approximately half of the B-group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl). However, the serum lipid concentrations in the P-group subjects were almost stable during the experimental periods. The present results indicate the potential of the probiotic B. longum strain BL1 in serum lipid improvement.

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Research works printed but not linked: 4

  1. Asaoka, 1996, Effect of “CHOLECUT,” a drink containing depolymerized sodium alginate, on serum cholesterol levels in healthy males, Jpn. J. Nutr. Assess., 13, 460
  2. Bottazzi, 1986, Absorption of cholesterol by intestinal lactic acid bacteria, Ann. Microbiol., 36, 1
  3. Harvenaar, 19969, Stimulated assimilation, Dairy Ind. Int., 61, 17
  4. Kawase, 2001, Effect of administration of fermented milk with Streptococcus thermophilus TMC1543 on serum lipid levels induced by a high-cholesterol diet in adult subjects, Milchwissenschaft, 56, 496

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Metadata

Authors
Xiao, J. Z., Kondo, S., Takahashi, N., Miyaji, K., Oshida, K., Hiramatsu, A., Iwatsuki, K., Kokubo, S., & Hosono, A.
Affiliations
  • Morinaga (Japan) (JP)
  • Morinaga Milk Industry Co., Ltd. (Japan) (JP)
  • Shinshu University (JP)
Corresponding author
Xiao, J.Z.
ORCID
Venue
Journal of Dairy Science
Publisher
American Dairy Science Association
Published
2003-07
Volume
86
Issue
7
Pages
2452-2461
ISSN
0022-0302 (ISSN-L)
DOI
10.3168/jds.s0022-0302(03)73839-9
OpenAlex
W2163491850
Cited by
322
References
36
Citations by year
2026: 4 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 22 · 2020: 16 · 2019: 18 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 22 · 2014: 17 · 2013: 25 · 2012: 23
FWCI
11.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Dairy Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
Bifidobacterium longum, probiotics, fermented milk, serum lipids, serum cholesterol, LDL cholesterol, triglycerides, hypercholesterolemia, yogurt, Streptococcus thermophilus, Lactobacillus bulgaricus, dietary cholesterol
MeSH terms
Adult, Animals, Bifidobacterium, Bile, Cholesterol, Dairy Products, Fermentation, Gastric Juice, Humans, Hypercholesterolemia, Lipids, Cholesterol, LDL, Male, Middle Aged, Milk, Placebos, Triglycerides, Yogurt, Rats, Sprague-Dawley, Probiotics, Rats

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