Cited by 457Gut microbiota and healthLiver Disease Diagnosis and TreatmentGastrointestinal motility and disorders

The role of the gut microbiota in nonalcoholic fatty liver disease

Abu-Shanab, Ahmed, Quigley, Eamonn M. M.·2010·Nature Reviews Gastroenterology & Hepatology

Abstract

Important metabolic functions have been identified for the gut microbiota in health and disease. Several lines of evidence suggest a role for the gut microbiota in both the etiology of nonalcoholic fatty liver disease (NAFLD) and progression to its more advanced state, nonalcoholic steatohepatitis (NASH). Both NAFLD and NASH are strongly linked to obesity, type 2 diabetes mellitus and the metabolic syndrome and, accordingly, have become common worldwide problems. Small intestinal bacterial overgrowth of Gram-negative organisms could promote insulin resistance, increase endogenous ethanol production and induce choline deficiency, all factors implicated in NAFLD. Among the potential mediators of this association, lipopolysaccharide (a component of Gram-negative bacterial cell walls) exerts relevant metabolic and proinflammatory effects. Although the best evidence to support a role for the gut microbiota in NAFLD and NASH comes largely from animal models, data from studies in humans (albeit at times contradictory) is accumulating and could lead to new therapeutic avenues for these highly prevalent conditions.

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Crossref · 10.1038/nrgastro.2010.172

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Authors
Abu-Shanab, A., & Quigley, E. M. M.
Affiliations
University College Cork (IE)
Corresponding author
Quigley, Eamonn M. M.
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2010-11-02
Volume
7
Issue
12
Pages
691-701
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W1988039243
Cited by
457
References
162
Citations by year
2026: 7 · 2025: 16 · 2024: 20 · 2023: 21 · 2022: 26 · 2021: 43 · 2020: 28 · 2019: 40 · 2018: 39 · 2017: 38 · 2016: 35 · 2015: 36 · 2014: 37 · 2013: 34 · 2012: 25
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, gut-liver axis, small intestinal bacterial overgrowth, Gram-negative bacteria, lipopolysaccharide, insulin resistance, endogenous ethanol production, choline deficiency, obesity, type 2 diabetes, metabolic syndrome, prebiotics, probiotics, NAFLD pathogenesis
MeSH terms
Animals, Bacteria, Fatty Liver, Humans, Intestinal Mucosa, Intestines, Liver, Non-alcoholic Fatty Liver Disease

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