Cited by 418Protein Hydrolysis and Bioactive PeptidesRenin-Angiotensin System StudiesPeptidase Inhibition and Analysis

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Antihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790

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Yamamoto, Naoyuki, Akino, Atsuko, Takano, Toshiaki·1994·Journal of Dairy Science

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Abstract

Peptides derived from alpha s1- and beta-caseins by the Lactobacillus helveticus CP790 proteinase were investigated for their inhibitory activities against angiotensin I-converting enzyme. The antihypertensive effect of casein hydrolysates in strain SHR spontaneously hypertensive rats was also investigated. Both alpha s1- and beta-casein hydrolysates inhibited this enzyme. Some of these peptides showed enzyme inhibitory activity, and one of them from beta-casein inhibited the enzyme greatly; the concentration of an angiotensin I-converting enzyme inhibitor needed to inhibit 50% of the enzyme activity was 4 microM. The hydrolysate of casein demonstrated antihypertensive activity in spontaneously hypertensive rats at an orally administered dosage of 15 mg/kg of body weight. MILK fermented with L. helveticus CP790, containing about .3% peptides, also showed antihypertensive activity in SHR rats with 5 ml/kg of body weight (15 mg of peptide/kg); however, the milk fermented with L. helveticus CP791, a variant defective for proteinase activity, did not show this activity. Results suggested that the peptides liberated from casein by the proteinase in the culture medium showed antihypertensive effect in SHR rats.

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Authors: Yamamoto, N., Akino, A., & Takano, T.
Affiliations: Calpis Co., Ltd. (Japan) (JP)
ORCID: Yamamoto, Naoyuki
Venue: Journal of Dairy Science
Publisher: American Dairy Science Association
Published: 1994-04
Volume: 77
Issue: 4
Pages: 917-922
ISSN: 0022-0302 (ISSN-L)
DOI: 10.3168/jds.s0022-0302(94)77026-0
OpenAlex: W2165457361
Cited by: 418
References: 25
Citations by year: 2026: 5 · 2025: 11 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 6 · 2020: 22 · 2019: 16 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 22 · 2014: 15 · 2013: 12 · 2012: 22
FWCI: 2.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 9056 d)
Locations: Journal of Dairy Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
Keywords: antihypertensive peptides, casein hydrolysate, Lactobacillus helveticus, extracellular protease, angiotensin-converting enzyme inhibition, αs1-casein, β-casein, spontaneously hypertensive rats, fermented milk, bioactive peptides
MeSH terms: Amino Acid Sequence, Animals, Caseins, Fermentation, Hydrolysis, Hypertension, Lactobacillus, Male, Milk, Molecular Sequence Data, Peptide Fragments, Endopeptidases, Rats, Inbred SHR, Rats, Inbred WKY, Rats

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Antihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790

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