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Cited by 215Pituitary Gland Disorders and TreatmentsAdrenal and Paraganglionic TumorsNeuroendocrine Tumor Research Advances

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Cushing's disease: pathobiology, diagnosis, and management

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Lonser, Russell R., Nieman, Lynnette, Oldfield, Edward H.·2017·Journal of Neurosurgery
DOI 10.3171/2016.1.jns152119
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Abstract

Cushing's disease (CD) is the result of excess secretion of adrenocorticotropic hormone (ACTH) by a benign monoclonal pituitary adenoma. The excessive secretion of ACTH stimulates secretion of cortisol by the adrenal glands, resulting in supraphysiological levels of circulating cortisol. The pathophysiological levels of cortisol are associated with hypertension, diabetes, obesity, and early death. Successful resection of the CD-associated ACTH-secreting pituitary adenoma is the treatment of choice and results in immediate biochemical remission with preservation of pituitary function. Accurate and early identification of CD is critical for effective surgical management and optimal prognosis. The authors review the current pathophysiological principles, diagnostic methods, and management of CD.

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Metadata

Authors
Lonser, R. R., Nieman, L., & Oldfield, E. H.
Affiliations
  • The Ohio State University Wexner Medical Center (US)
  • National Institutes of Health (US)
  • University of Virginia Health System (US)
Corresponding author
Lonser, Russell R.
ORCID
Venue
Journal of Neurosurgery
Publisher
Journal of Neurosurgery Publishing Group (JNSPG)
Published
2017-02
Volume
126
Issue
2
Pages
404-417
ISSN
  • 0022-3085 (ISSN-L)
  • 1933-0693
DOI
10.3171/2016.1.jns152119
OpenAlex
W2340359999
Cited by
215
References
0
Citations by year
2026: 16 · 2025: 27 · 2024: 19 · 2023: 25 · 2022: 33 · 2021: 25 · 2020: 21 · 2019: 18 · 2018: 16 · 2017: 11
FWCI
2.35
Type
journal article
Language
en
Open access
Locations
  • Journal of neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
Keywords
Cushing's disease, hypercortisolism, cortisol excess, hypertension, diabetes mellitus, obesity, pituitary surgery, biochemical remission, diagnosis, pathophysiology
MeSH terms
Humans, Pituitary ACTH Hypersecretion

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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