Mild Cognitive Impairment: Differential Atrophy in the Hippocampal Subfields
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BACKGROUND AND PURPOSE: Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer disease, but it seems insufficiently sensitive for the aMCI stage. We postulated that some hippocampus subfields are specifically atrophic in aMCI and that measuring hippocampus subfield volumes will improve sensitivity of MR imaging to detect aMCI. MATERIALS AND METHODS: We evaluated episodic memory and hippocampus subfield volume in 15 patients with aMCI and 15 matched controls. After segmentation of the whole hippocampus from clinical MR imaging, we applied a new computational method allowing fully automated segmentation of the hippocampus subfields. This method used a Bayesian modeling approach to infer segmentations from the imaging data. RESULTS: In comparison with controls, subiculum and CA2-3 were significantly atrophic in patients with aMCI, whereas total hippocampus volume and other subfields were not. Total hippocampus volume in controls was age-related, whereas episodic memory was the main explanatory variable for both the total hippocampus volume and the subfields that were atrophic in patients with aMCI. Segmenting subfields increases sensitivity to diagnose aMCI from 40% to 73%. CONCLUSIONS: Measuring CA2-3 and subiculum volumes allows a better detection of aMCI.
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The subiculum is one of the earliest affected regions in AD or prodromal AD patients.
“pathological studies have also indicated that the subiculum is one of the earliest affected regions in AD or prodromal AD patients [4, 15, 44, 73].”
From Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology (2023) · cites this paper as [44]
Discrepancies exist as regards to the area of largest difference between HC and aMCI patients, probably reflecting variations in the anatomical landmarks used for subfield delineation.
“However, discrepancies exist as regards to the area of largest difference between HC and aMCI patients (CA1 (Pluta et al., 2012), CA1–CA2 transition area (Mueller et al., 2010) or subiculum (Hanseeuw, 2011), probably reflecting variations in the anatomical landmarks used for subfield delineation”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Hanseeuw, 2011
Subfield measurements were more accurate than global hippocampal volumetry to differentiate aMCI from HC.
“we showed that subfield measurements were more accurate than global hippocampal volumetry to differentiate aMCI from HC”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Hanseeuw, 2011
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- Authors
- Hanseeuw, B. J., Van Leemput, K., Kavec, M., Grandin, C., Seron, X., & Ivanoiu, A.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Hanseeuw, B.J.
- ORCID
- Hanseeuw, B.J.
- Venue
- American Journal of Neuroradiology
- Published
- 2011-08-11
- Volume
- 32
- Issue
- 9
- Pages
- 1658-1661
- ISSN
- 0195-6108 (ISSN-L)
- 1936-959X
- PMC
- PMC3268157
- OpenAlex
- W2164876002
- Cited by
- 110
- References
- 17
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 11 · 2015: 14 · 2014: 15 · 2013: 9 · 2012: 10
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- American Journal of Neuroradiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Funders
- Massachusetts General Hospital
- Academy of Finland
- Fonds De La Recherche Scientifique - FNRS
- Centre d'Imagerie BioMédicale
- National Institutes of Health
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (P41-RR014075)
- National Institute of Neurological Disorders and Stroke (R01NS052585)
- National Institute of Biomedical Imaging and Bioengineering (R01EB006758, R01EB009051, R01EB013565)
- National Center for Research Resources (P41RR014075)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- mild cognitive impairment, hippocampal subfields, hippocampal atrophy, subiculum, CA2/3, hippocampal volumetry, episodic memory, Bayesian segmentation, Alzheimer's disease diagnosis, MRI biomarkers
- MeSH terms
- Alzheimer Disease, Atrophy, Bayes Theorem, Hippocampus, Humans, Magnetic Resonance Imaging, Models, Neurological, Neuropsychological Tests, Sensitivity and Specificity, Dentate Gyrus, CA2 Region, Hippocampal, CA3 Region, Hippocampal, Cognitive Dysfunction, Memory, Episodic
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