Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla
Abstract
Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T(1)-weighted images were acquired from 19 Alzheimer's disease patients [age 76 +/- 6 years, three males, Mini-Mental State Examination 13 +/- 4] and 19 controls (age 74 +/- 5 years, 11 males, Mini-Mental State Examination 29 +/- 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P < 0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P < 0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing.
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The CA1 subfield was found significantly atrophic in a study using the same automated method as ours and in studies using manual segmentation or 3D surface reconstruction, irrespective of dementia severity.
“the CA1 subfield was found significantly atrophic in a study that used the same automated method as ours and included patients with similar dementia severity [33] and in studies that used a procedure involving manual segmentation of hippocampal subfields [34], [35] or based on 3D surface reconstruction and shape analysis of the hippocampi [36], [37]”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [36]
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- Authors
- Frisoni, G. B., Ganzola, R., Canu, E., Rub, U., Pizzini, F. B., Alessandrini, F., Zoccatelli, G., Beltramello, A., Caltagirone, C., & Thompson, P. M.
- Affiliations
- University of California, Los Angeles (US)
- Goethe University Frankfurt (DE)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11-06
- Volume
- 131
- Issue
- 12
- Pages
- 3266-3276
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2090537659
- Cited by
- 256
- References
- 53
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 13 · 2020: 24 · 2019: 19 · 2018: 10 · 2017: 17 · 2016: 14 · 2015: 27 · 2014: 25 · 2013: 15 · 2012: 12
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, normal aging, hippocampal atrophy, hippocampal subfields, CA1, presubiculum, hippocampal volume, T1-weighted imaging, 3T MRI
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain Mapping, Female, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales
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