Hippocampal subfield analysis in medication-naïve female patients with major depressive disorder
Abstract
Background Hippocampal volume loss is known as the best-replicated finding of structural brain imaging studies on major depressive disorder (MDD). Several evidences suggest localized mechanisms of hippocampal neuroplasticity lead the brain imaging studies on the hippocampus and MDD to perform analyses in the subfield level. The aim of this study was to investigate the differences in total and subfield hippocampal volumes, between medication-naïve female MDD patients and healthy controls, through automated segmentation and volumetric methods.Methods Twenty medication-naïve female patients diagnosed with MDD and 21 age-matched healthy controls, underwent T1-weighted structural magnetic resonance scanning. Total volumes of both hippocampi and subfield regions were calculated by the automated procedure for volumetric measures implemented in FreeSurfer and automated segmentation method by Van Leemput et al.Results We observed patients to have significantly smaller volumes of the left hippocampus, subiculum, cornu ammonis 2-3, cornu ammonis 4-dentate gyrus, and right subiculum compared to healthy controls. There were no significant predictors for these subfield region volumes among the illness burden-related parameters including duration of illness, number of depressive episodes, severity of depressive symptoms and memory performances.Limitations Our findings relied on the data of only female participants.Conclusions We found significant volume reductions in several hippocampal subfield regions in medication-naïve female MDD patients. Our results are consistent with neurobiological evidences on hippocampal neuroplasticity in MDD, and replicate previous findings that suggest morphologic changes of hippocampal subfields in MDD patients.
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Hippocampal subfield analyses show smaller cornu ammonis 1-3, dentate gyrus/cornu ammonis 4, and subiculum volumes, plus anterior and posterior subdivisions, in major depressive disorder.
“those that have parcellated the hippocampus into different subfields have found evidence for reduced cornu ammonis 1–3, dentate gyrus/cornu ammonis 4, and subiculum volumes as well as both anterior and posterior subdivisions in MDD (e.g., 15,16).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [15]
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Sex Differences in the Neurobiology of Stress
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Impact of Frailty on Hippocampal Volume in Patients with Chronic Obstructive Pulmonary Disease
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Brain Activation during Memory Retrieval is Associated with Depression Severity in Women
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Segmenting the human brain in population-based studies
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- Authors
- Han, K.-M., Won, E., Sim, Y., & Tae, W.-S.
- Affiliations
- Korea University (KR)
- Korea University Anam Hospital (KR)
- Corresponding author
- Tae, Woo-Suk
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 194
- Pages
- 21-29
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2235446523
- Cited by
- 63
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 6 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 1 · 2015: 1
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF) (NRF-2015R1A5A7037674)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- major depressive disorder, hippocampal subfields, hippocampal atrophy, drug-naive patients, female patients, subiculum, cornu ammonis, dentate gyrus, hippocampal plasticity, hippocampal subfield segmentation, brain structural changes
- MeSH terms
- Adolescent, Adult, Aged, Major Depressive Disorder, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Middle Aged, Neuronal Plasticity, Organ Size, Case-Control Studies, Young Adult
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