Enhancement of antibody production in mice by dietary Spirulina platensis
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Mice fed a Spirulina platensis diet showed increased numbers of splenic antibody-producing cells in the primary immune response to sheep red blood cells (SRBC). However, immunoglobulin G (IgG)-antibody production in the secondary immune response was hardly affected. The percentage of phagocytic cells in peritoneal macrophages from the mice fed S. platensis diet, as well as the proliferation of spleen cells by either concanavalin A (Con A) or phytohemagglutinin (PHA) was significantly increased. Addition of a hot-water extract of S. platensis (SHW) to an in vitro culture of spleen cells markedly increased proliferation of these cells, whereas culture of thymus cells was scarcely affected. The Spirulina extract also significantly enhanced interleukin-1 (IL-1) production from peritoneal macrophages. Addition to the in vitro spleen cell culture of SHW as well as the supernatant of macrophages stimulated with SHW resulted in enhancement of antibody production, that is, an increase of the number of PFC. These results suggest that Spirulina enhances the immune response, particularly the primary response, by stimulating macrophage functions, phagocytosis, and IL-1 production.
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Arthrospira platensis activates 164 functions of macrophages, phagocytosis, and the primary immune response of the cell.
“Arthrospira platensis activates 164 functions of macrophages, phagocytosis, and the primary immune response of the cell [79].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [79]
The Abstract and the discussion section on IL-1 production report enhanced macrophage phagocytosis and IL-1 production, alongside a stronger primary immune response in mice. They do not report activation of “164 functions”; the discussion identifies phagocytosis and IL-1 production as the macrophage functions at issue. (LLM, conf=0.90)
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Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions
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Studies of the Pharmacology and Toxicology of Spirulina Maxima (SMNJU.02)
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- Authors
- HAYASHI, O., KATOH, T., & OKUWAKI, Y.
- Affiliations
- Japan Nutrition University (JP)
- Venue
- Journal of Nutritional Science and Vitaminology
- Published
- 1994
- Volume
- 40
- Issue
- 5
- Pages
- 431-441
- ISSN
- 0301-4800 (ISSN-L)
- 1881-7742
- OpenAlex
- W2089254287
- Cited by
- 129
- References
- 16
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 12 · 2012: 10
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Nutritional Science and Vitaminology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Keywords
- Spirulina platensis, dietary supplementation, antibody production, primary immune response, secondary immune response, peritoneal macrophages, phagocytosis, interleukin-1, spleen cell proliferation, concanavalin A, phytohemagglutinin, thymus cells, sheep red blood cells, immunomodulation
- MeSH terms
- Cyanobacteria, Animals, Antibody Formation, Cell Division, Concanavalin A, Diet, Erythrocytes, Immunoglobulin G, Interleukin-1, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Phagocytes, Phytohemagglutinins, Sheep, Spleen, Macrophages, Peritoneal, Mice
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