Polyphenols: Modulators of Platelet Function and Platelet Microparticle Generation?
Open accessAbstract
Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the high levels of PMPs generated in such situations pose a thrombotic risk that can lead to strokes or myocardial infarctions. Interestingly, dietary polyphenols are gaining much attention due to their potential to mimic the antiplatelet activity of treatment drugs such as aspirin and clopidogrel that target the glycoprotein VI (GPVI)–collagen and cyclooxygenease-1 (COX-1)–thromboxane platelet activation pathways respectively. Platelet function tests such as aggregometry and flow cytometry used to monitor the efficacy of antiplatelet drugs can also be used to assess the antiplatelet potential of dietary polyphenols. Despite the low bioavailability of polyphenols, several in vitro and dietary intervention studies have reported antiplatelet effects of polyphenols. This review presents a summary of platelet function in terms of aggregation, secretion, activation marker expression, and PMP release. Furthermore, the review will critically evaluate studies demonstrating the impact of polyphenols on aggregation and PMP release.
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Polyphenols such as oleuropein found in olive oil reduce oxidative stress.
“Studies showed that polyphenols, such as oleuropein found in olive oil, reduce oxidative stress, and inhibit the COX1 pathway, which is involved in platelet aggregation [59].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [59]
Polyphenols such as oleuropein inhibit the COX1 pathway, which is involved in platelet aggregation.
“Studies showed that polyphenols, such as oleuropein found in olive oil, reduce oxidative stress, and inhibit the COX1 pathway, which is involved in platelet aggregation [59].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [59]
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- Authors
- Ed Nignpense, B., Chinkwo, K. A., Blanchard, C. L., & Santhakumar, A. B.
- Affiliations
- School of Biomedical Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW 2678, Australia
- Australian Research Council (AU)
- Corresponding author
- Santhakumar, Abishek B.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-12-24
- Volume
- 21
- Issue
- 1
- Pages
- 146
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6981839
- OpenAlex
- W2997141981
- Cited by
- 97
- References
- 113
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 26 · 2021: 18 · 2020: 8 · 2018: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Charles Sturt University Research Output (CRO) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Australian Research Council (Project ID 100737)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- dietary polyphenols, platelet function, platelet microparticles, platelet aggregation, platelet activation, antiplatelet activity, platelet secretion, bioavailability, atherosclerosis, thrombosis, platelet function testing
- MeSH terms
- Blood Platelets, Flow Cytometry, Humans, Platelet Function Tests, Atherosclerosis, Cyclooxygenase 1, Polyphenols
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