Cited by 97Platelet Disorders and TreatmentsPhytochemicals and Antioxidant ActivitiesAntiplatelet Therapy and Cardiovascular Diseases

Polyphenols: Modulators of Platelet Function and Platelet Microparticle Generation?

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Ed Nignpense, Borkwei, Chinkwo, Kenneth A., Blanchard, Christopher L., Santhakumar, Abishek B.·2019·International Journal of Molecular Sciences

Abstract

Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the high levels of PMPs generated in such situations pose a thrombotic risk that can lead to strokes or myocardial infarctions. Interestingly, dietary polyphenols are gaining much attention due to their potential to mimic the antiplatelet activity of treatment drugs such as aspirin and clopidogrel that target the glycoprotein VI (GPVI)–collagen and cyclooxygenease-1 (COX-1)–thromboxane platelet activation pathways respectively. Platelet function tests such as aggregometry and flow cytometry used to monitor the efficacy of antiplatelet drugs can also be used to assess the antiplatelet potential of dietary polyphenols. Despite the low bioavailability of polyphenols, several in vitro and dietary intervention studies have reported antiplatelet effects of polyphenols. This review presents a summary of platelet function in terms of aggregation, secretion, activation marker expression, and PMP release. Furthermore, the review will critically evaluate studies demonstrating the impact of polyphenols on aggregation and PMP release.

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Authors
Ed Nignpense, B., Chinkwo, K. A., Blanchard, C. L., & Santhakumar, A. B.
Affiliations
  • School of Biomedical Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW 2678, Australia
  • Australian Research Council (AU)
Corresponding author
Santhakumar, Abishek B.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-12-24
Volume
21
Issue
1
Pages
146
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2997141981
Cited by
97
References
113
Citations by year
2026: 8 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 26 · 2021: 18 · 2020: 8 · 2018: 1
FWCI
2.07
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Charles Sturt University Research Output (CRO) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Australian Research Council (Project ID 100737)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords
dietary polyphenols, platelet function, platelet microparticles, platelet aggregation, platelet activation, antiplatelet activity, platelet secretion, bioavailability, atherosclerosis, thrombosis, platelet function testing
MeSH terms
Blood Platelets, Flow Cytometry, Humans, Platelet Function Tests, Atherosclerosis, Cyclooxygenase 1, Polyphenols

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