Analgesic and antioxidant activity of mangiferin and its derivatives: The structure activity relationship
Open accessAbstract
Mangiferin, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, obtained directly from methanolic extracts of Bombax ceiba leaves in substantial amounts demonstrated strong antioxidant activity (EC(50) 5.8+/-0.96 mug/ml or 13.74 muM) using DPPH assay comparable to rutin, commonly used as antioxidant for medical purposes. The acetyl and cinnamoyl derivatives were found to be less active than mangiferin whereas, methyl and 3,6,7-trimethylether tetraacetate derivatives were inactive implying that for antioxidant activity, free hydroxyl groups and catechol moiety are essential. Moreover, mangiferin showed hepatoprotective activity against carbon tetrachloride induced liver injury further supporting the free radical scavenging property in the in vivo system. Additionally, plant extracts and mangiferin failed to exhibit acute anti-inflammatory activity whereas, it displayed significant analgesic effect in acetic acid-induced writhing and hot plate tests in mice. Using naloxone, it was revealed that plant extracts induced analgesia was independent of opioid receptor, whereas, mangiferin demonstrated significant interaction with it at peripheral site with a slight contribution at the neuronal level.
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MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects.
“It has been widely reported that MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects [20,21].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [21]
The Abstract reports antioxidant activity and protection against carbon-tetrachloride-induced liver injury. Results and Discussion reports an immune-related macrophage effect but found no acute anti-inflammatory activity in the rat-paw-edema test. It also reports that mangiferin was inactive as an anti-HIV agent; the anti-HIV result concerned a mangiferin derivative, so this paper does not support the antiviral claim for mangiferin itself. Page numbers are unavailable in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredMangiferin has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects.
“It has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects (1)(2)(3).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [1]
The Abstract reports antioxidant, hepatoprotective and analgesic effects of mangiferin. Results and Discussion also describes a chemoprotective finding in a rat colon-carcinogenesis model, but reports that mangiferin was inactive in the paper’s cancer-cell and anti-HIV tests. The cited passages do not establish the claimed antiaging, antibacterial or antidiabetic effects; the macrophage finding is narrower than the broad claim of immunomodulatory activity. (LLM, conf=0.90)
Experimental — accuracy not yet measuredPositions 6 and 7 of MGN are mainly responsible for its antioxidant property.
“According to Dar et al. (2005), positions 6 and 7 (Fig. 1b) of MGN are mainly responsible for its antioxidant property.”
From Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin (2013) · cites this paper as Dar et al., 2005
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Mangiferin: A natural miracle bioactive compound against lifestyle related disorders
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., & Sultan, M. T. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0449-y · Cited by 366 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“It has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects (1-3).”
Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182937 · Cited by 136 · see citing works
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Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin
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Anti-oxidative effect of mangiferin-chitosan nanoparticles on oxidative stress-induced renal cells
Samadarsi, R., & Dutta, D. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.112 · Cited by 57 · see citing works
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“It has been widely reported that MGF offers a wide plethora of promising beneficial properties such as antioxidant, antiviral, anti-inflammatory, immunomodulatory, and cytoprotective effects [20,21].”
BackgroundChen, X., & Huang, J. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10654 · Cited by 7 · see citing works
- Authors
- Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T.
- Affiliations
- University of Karachi (PK)
- H.E.J. Research Institute of Chemistry, University of Karachi
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2005
- Volume
- 28
- Issue
- 4
- Pages
- 596-600
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1976717028
- Cited by
- 289
- References
- 2
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 25 · 2022: 51 · 2021: 19 · 2020: 20 · 2019: 14 · 2018: 17 · 2017: 10 · 2016: 15 · 2015: 13 · 2014: 10 · 2013: 19 · 2012: 17
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- mangiferin, Bombax ceiba, antioxidant activity, analgesic activity, structure-activity relationship, acetyl derivatives, cinnamoyl derivatives, catechol moiety, hepatoprotection, carbon tetrachloride-induced liver injury, opioid receptor interaction, anti-inflammatory activity, DPPH radical scavenging
- MeSH terms
- Analgesics, Animals, Aspirin, Morphine, Plant Extracts, Structure-Activity Relationship, Molecular Structure, Free Radical Scavengers, Bombax, Xanthones, Mice, Rats
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