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Behavioral methods to study anxiety in rodents
Open accessAbstract
Stress is a precipitating factor for anxiety-related disorders, which are among the leading forms of psychiatric illness and impairment in the modern world. Rodent-based behavioral tests and models are widely used to understand the mechanisms by which stress triggers anxiety-related behaviors and to identify new treatments for anxiety-related disorders. Although substantial progress has been made and many of the key neural circuits and molecular pathways mediating stress responsiveness have been characterized, these advances have thus far failed to translate into fundamentally new treatments that are safer and more efficacious in humans. The purpose of this article is to describe methods that have been historically used for this type of research and to highlight new approaches that align with recent conceptualizations of disease symptomatology and that may ultimately prove to be more fruitful in facilitating the development of improved therapeutics.
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![Figure 1 Assessment of the acoustic startle reflex in rodents. (A) Sprague-Dawley rat in an apparatus that quantifies startle responses. Rats are placed within a nonconfining holder to minimize restraint stress. Startle response is induced by a burst of white noise delivered via a speaker located behind the rat. The force displaced is quantified by an accelerometer beneath the holder. (B) Acute effects of the stress-peptide corticotropin-releasing factor (CRF; administered intracerebroventricularly [ICV]) or vehicle only (VEH) on acoustic startle in 150-minute test sessions. Data are expressed as (%) change from pretreatment tests. CRF produces a dosedependent increase in startle. *P<0.05;**P<0.01 ; Tukey's t-tests.](/paper-figures/1cf377c1a83e4ebeb6145fc99fd6e50c/behavioral-methods-to-study-anxiety-in-rodents-figure-1.jpg)
![Figure 2 Electroencephalogram/electromyogram (EEG/EMG) telemetry in rodents as a potential index of stress. The use of telemetry in mice and rats allows derivation of numerous metrics, including sleep architecture and circadian rhythm. (A) C57BL/6 mouse next to a transmitter (manufacturer: Data Sciences International) that is subcutaneously implanted to allow remote measurements: EEG/EMG, activity, and body temperature. (B) Representative example of a brief period of EEG and EMG signal from awake, slow-wave sleep, or rapid eye movement (REM) sleep. (C) Regular circadian fluctuations of activity and temperature in C57BL/6J mice, where 0-12 h is the light phase and 12-24 h is the dark phase. These cycles can be dysregulated by stress. (D) Effects of the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP; administered intracerebroventricularly [ICV]) on exploratory behavior in the elevated plus maze (EPM) (left) and REM sleep (right) in C57BL/6J mice. PACAP decreased exploratory behavior and increased REM during the dark phase, au, arbitrary units; ZT, zeitgeber time](/paper-figures/21613f59d70c4c3ba713cd09759fad89/behavioral-methods-to-study-anxiety-in-rodents-figure-2.jpg)
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“Symptoms of mental illnesses are accompanied by emotional, cognitive, and motivational aspects that are not attributable to the lower mammal species being studied (Lezak et al., 2017).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Lezak et al., 2017
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“Acoustic startle is a measurable “flinch” to a delivered white noise, that has an amplitude that can be quantified in units of force, and is hypothesized to reflect the state of alertness associated with increased anxiety (Lezak et al., 2017).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Lezak et al., 2017
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“For example, pairing an aversive unconditioned stimuli, such as a footshock, with a tone/sound, light, or a context/environment (neutral conditioned stimuli) can elicit fear responses to the conditioned stimuli in the absence of the footshock on re-exposure to the conditioned stimulus (Lezak et al., 2017).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Lezak et al., 2017
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581
Pellow, S., & File, S. E. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90552-6 · Cited by 1,534
Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.109 · Cited by 1,513
Bourin, M., & Hascoët, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01274-3 · Cited by 1,440
Research works printed but not linked: 6
- Walker DL., 2008, Brain Struct Funct., 213, 29, 10.1007/s00429-008-0183-3 · DOI · Paper page
- Deacon RM., 2011, J Vis Exp., doi:10.3791
- Nemeroff CB., 2004, J Clin Psychiatry., 65, 18
- Pryce CR., 2002, News Physiol Sci., 17, 150
- Hamm AO., 2014, Restor Neurol Neurosci., 32, 79
- Davis M., 2008, Rev Neurosci., 19, 171
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Items 101–200 of 288
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Olavarría‐Ramírez, L., Cooney-Quane, J., Murphy, G., McCafferty, C. P., Cryan, J. F., & Dockray, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.105013 · Cited by 17
Escelsior, A., Sterlini, B., Murri, M. B., Serafini, G., Aguglia, A., da Silva, B. P., Corradi, A. M., Valente, P., & Amore, M. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112734 · Cited by 16
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Norris, M. R., Becker, L. J., Bilbily, J., Chang, Y. A., Borges, G., Dunn, S. S., Madasu, M. K., Vazquez, C. R., Cariello, S. A., Al‐Hasani, R., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000003123 · Cited by 15
Oatess, T. L., Harrison, F. E., Himmel, L. E., & Jones, C. P. (2020) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-19-000159 · Cited by 14
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Prvulović, M., Todorovic, S. T., Milanović, D., Jović, M., Vujovic, P. Z., Kanazir, S., & Mladenović, A. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111666 · Cited by 14
Sadeghi, M. A., Hemmati, S., Yousefi‐Manesh, H., Foroutani, L., Nassireslami, E., Zoshk, M. Y., Hosseini, Y., Abbasian, K., Dehpour, A. R., & Chamanara, M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02578-3 · Cited by 14
Faraji, J., Singh, S., Soltanpour, N., Sutherland, R. J., & Metz, G. A. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112332 · Cited by 14
Souza, M. F., Medeiros, K. A. A. L., Lins, L. C. R. F., Bispo, J. M. M., de Gois, A. M., Santos, E. R., Almeida-Souza, T. H., Melo, J. E. C., Franco, H. S., Silva, R. S., et al. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.01.004 · Cited by 13
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Zelli, S., Brancato, A., Mattioli, F., Pepe, M., Alleva, E., Carbone, C., Cannizzaro, C., & Adriani, W. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12709 · Cited by 13
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Yavuz, Y., Yeşilay, G., Tuna, B. G., Maharramov, A., Çulha, M., Erdogan, C. S., İnhan-Garip, G. A., & Yılmaz, B. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04632-9 · Cited by 12
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Wagner, N. R., & MacDonald, J. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.009 · Cited by 12
Holvoet, H., Long, D. M., Yang, L., Choi, J., Marney, L. C., Poeck, B., Maier, C. S., Soumyanath, A., Kretzschmar, D., & Strauß, R. (2023) · Nutrients · doi:10.3390/nu15184016 · Cited by 11
Perinatal exposure to bisphenol A or S: Effects on anxiety-related behaviors and serotonergic system
Bonaldo, B., Casile, A., Ostuni, M. T., Bettarelli, M., Nasini, S., Marraudino, M., Panzica, G., & Gotti, S. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140827 · Cited by 11
Serrano, M., Saumell-Esnaola, M., Ocerin, G., del Caño, G. G., Puente, N., Sallés, J., de Fonseca, F. R., Rodríguez-Arias, M., Gerrikagoitia, I., & Grandes, P. (2024) · Nutrients · doi:10.3390/nu16244344 · Cited by 11
Dagher, M., Cahill, C. M., & Andrews, A. M. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100046 · Cited by 14
Jacobs, D. S., Allen, M. C., Park, J., & Moghaddam, B. (2022) · eLife · doi:10.7554/elife.78912 · Cited by 11
Xie, J., Li, Y., Liang, Y., Kui, H., Wang, C., & Huang, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116571 · Cited by 11
Mantanona, C. P., Alsiö, J., Elson, J. L., Fisher, B. M., Dalley, J. W., Bussey, T. J., & Pienaar, I. S. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01957-y · Cited by 13
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Daniels, S., Horman, T., Lapointe, T., Melanson, B. A., Storace, A., Kennedy, S. H., Frey, B. N., Rizvi, S. J., Hassel, S., Müller, D. J., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.108 · Cited by 11
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Penrod, R. D., Taniguchi, M., Kearns, A. M., Hopkins, J. L., & Reichel, C. M. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad059 · Cited by 5
Johnston, M. P., & Wanat, M. J. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1038236 · Cited by 7
Myles, E. M., Hamm, S. I., Allden, S. N., Romkey, I. D., O’Leary, M. E., & Perrot, T. S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114184 · Cited by 5
Moazzam, S., Noorjahan, N., Jin, Y., Nagy, J. I., Kardami, E., & Cattini, P. A. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13258 · Cited by 7
Rauch, E., Ari, C., & Kovács, Z. (2023) · Nutrients · doi:10.3390/nu15204412 · Cited by 5
Cavalcanti, C. C. L., Manhães‐de‐Castro, R., Chaves, W. F., Cadena-Burbano, E. V., Antônio-Santos, J., & Aragão, R. D. S. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114869 · Cited by 5
A test for studying sociability of the common shrew, Sorex araneus
Shchipanov, N. A., & Demidova, T. B. (2020) · Russian Journal of Theriology · doi:10.15298/rusjtheriol.19.2.01 · Cited by 5
Goldman, A. J., Smalley, J. L., Mistry, M., Krenzlin, H., Zhang, H., Dhawan, A., Caldarone, B. J., Moss, S. J., Silbersweig, D., Lawler, S. E., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0677-1 · Cited by 5
Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond
Gómez‐Gonzalo, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062774 · Cited by 4
Behavioral and transcriptomic effects of a novel cannabinoid on a rat valproic acid model of autism
Loomis, S., Silva, D. G., Savopoulos, R., Cilia, J., Li, J. S. Y., Davis, M. D., Virley, D. J., Foley, A., Loro, E., & McCreary, A. C. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110450 · Cited by 5
The role of TNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract
Kim, S. (2022) · Hispana · doi:10.14670/hh-18-393 · Cited by 4
Rahman, M. F., Yuksel, C. B., & McGowan, P. O. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.003 · Cited by 5
Mujtaba, S., Patro, I. K., & Patro, N. (2023) · Brain Sciences · doi:10.3390/brainsci13101360 · Cited by 4
A conserved role for frizzled in sleep architecture
Gessner, N. R., Peiravi, M., Zhang, F., Yimam, S., Springer, D., & Harbison, S. T. (2023) · SLEEP Advances · doi:10.1093/sleepadvances/zpad045 · Cited by 4
Li, K., Liao, G. Y., Keely, A., Yu, S., Pettan-Brewer, C., & Ladiges, W. (2024) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2024.03.133 · Cited by 4
Age-associated increase in anxiety-like behavior in Lpaatδ/Agpat4 knockout mice
Chan, J. Z., Fernandes, M. F., Hashemi, A., Grewal, R. S., Mardian, E. B., Bradley, R. M., & Duncan, R. E. (2021) · Current Research in Behavioral Sciences · doi:10.1016/j.crbeha.2021.100042 · Cited by 4
Omolaso, B. O., Ogunmiluyi, O. E., Adeniran, A. G., Adesanwo, J. K., & Akinlaja, D. O. (2024) · Nutrire · doi:10.1186/s41110-024-00286-3 · Cited by 4
Wang, J., Bley, V., Jiang, J., Zhang, Y., Qin, Y., Feng, H., Liu, Y., Li, R., Wang, C., He, S., et al. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110569 · Cited by 3
Wnuk, H. K., Orden, K. A. V., & Wang, K. H. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106451 · Cited by 5
Mograbi, K. D. M., Okeowo, O. M., Sumarán, P., Dale, C. S., de Carvalho, M. C., Covolan, L., Hamani, C., & Suchecki, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05375-6 · Cited by 3
Anderson, L. G., Tischer, A. E., Bock, R., Michaelides, M., & Alvarez, V. A. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04033-2 · Cited by 3
Nádeníček, J., Voslářová, E., Vojtkovská, V., Todorović, Z., & Večerek, V. (2022) · Acta Veterinaria Brno · doi:10.2754/avb202291040391 · Cited by 3
Azizi, P., Najafi, A., Samizadeh, M., Mohamadian, M., Jabbari, A., Rezaie, M., & Vaseghi, S. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70216 · Cited by 4
Vaughan, G. J., Lehr, M., Magardino, G., Kelley, A. M., Chan, M. A., Heitkamp, M. C., Yorgason, J. T., & Karkhanis, A. N. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100231 · Cited by 3
Sex Differences in the Ventral Subiculum's Microcircuitry and Function
Miller, C. N., & Aoto, J. N. (2025) · Hippocampus · doi:10.1002/hipo.70054 · Cited by 6
de Assis, P. M., Ferrarini, E. G., Baldasso, G. M., Paes, R. S., Gouvêa, M. C., Segundo, C. E. N., Borrelli, F., Brandão, M. A. F., Capasso, R., Dutra, R. C., et al. (2021) · Pharmaceutical Sciences · doi:10.34172/ps.2021.59 · Cited by 3
García, J. C. P., Li, R., Kikura‐Hanajiri, R., Tanaka, Y., & Ishii, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063083 · Cited by 3
Wang, C. Y., Sun, Y., Xing, Y., Liu, K., & Xu, K. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148914 · Cited by 4
Genomic contributions to anxiety disorders
Dalvie, S., Koen, N., & Stein, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813176-3.00024-9 · Cited by 3
George, B., Gokhale, S. D., Yaswanth, P. M., Vijayan, A., Devika, S., & Vasu, S. T. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136357 · Cited by 3
The bed nucleus of the stria terminalis in threat detection: task choice and rodent experience
Sherman, E. R., Thomas, J. J., & Cahill, E. (2022) · Emerging Topics in Life Sciences · doi:10.1042/etls20220002 · Cited by 4
Metadata
- Authors
- Lezak, K. R., Missig, G., & Carlezon Jr, W. A.
- Affiliations
- Harvard University (US)
- Behavioral Genetics Laboratory, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2017-06-30
- Volume
- 19
- Issue
- 2
- Pages
- 181-191
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC5573562
- OpenAlex
- W2984369896
- Cited by
- 290
- References
- 100
- Citations by year
- 2026: 16 · 2025: 39 · 2024: 35 · 2023: 45 · 2022: 47 · 2021: 39 · 2020: 36 · 2019: 25 · 2018: 7 · 2017: 1
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh063266-25)
- National Institute of Mental Health (R01-MH063266)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- anxiety, stress, anxiety-related disorders, stress responsiveness, translational research, behavioral tests
- MeSH terms
- Animals, Anxiety Disorders, Behavior, Animal, Disease Models, Animal, Biomedical Research, Mice, Rats, Translational Research, Biomedical
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