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Cited by 320

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Emergence of the Ehrlichioses as Human Health Problems

Open access
·1996·Emerging Infectious Diseases
DOI 10.3201/eid0201.960102
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Abstract

Ehrlichiae are small, gram-negative, obligately intracellular bacteria that reside within a phagosome. The first human ehrlichial infection was recognized in the United States in 1987. It was later shown to be caused by a new species, Ehrlichia chaffeensis. In 1994, an ehrlichial pathogen within neutrophils that is closely related to the known veterinary pathogens E. equi and E. phagocytophila was found to infect humans. Molecular methods were required to detect, characterize, and identify these fastidious and uncultivated bacteria. Subsequently, E. chaffeensis infection was documented in more than 400 patients in 30 states, Europe, and Africa. Likewise, approximately 170 cases of human granulocytic ehrlichiosis have been diagnosed, most since 1994, predominantly in the upper midwestern and northeastern states, but also in northern California. The disease caused by ehrlichiae is generally undifferentiated but is often associated with leukopenia, thrombocytopenia, and elevated serum hepatic transaminase levels in tick-exposed patients. Infection ranges from subclinical to fatal; tetracycline appears to be an effective therapy. The emergence of these two newly recognized tickborne infections as threats to human health is probably due to increased clinical cognizance, but as in other emerging tickborne infections, it is likely that the rapid increase in identified cases signals a true emergence of disease associated with a changing vector-host ecology.

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Metadata

Venue
Emerging Infectious Diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Published
1996-03
Volume
2
Issue
1
Pages
18-29
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
DOI
10.3201/eid0201.960102
OpenAlex
W2124239727
Cited by
320
References
31
FWCI
25.11
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Emergence of the Ehrlichioses as Human Health Problems. https://app.cochat.ai/papers/10.3201/eid0201.960102
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Emergence of the Ehrlichioses as Human Health Problems. (1996). Emerging Infectious Diseases. https://doi.org/10.3201/eid0201.960102

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.