Biofilm on Ventriculo-Peritoneal Shunt Tubing as a Cause of Treatment Failure in Coccidioidal Meningitis
Open accessAbstract
We describe a case of recurrent coccidioidal meningitis in which a fungal biofilm on the tip of ventriculo-peritoneal shunt tubing was likely responsible for a 4-year persistence of Coccidioides immitis, despite the patient's taking an adequate dosage of fluconazole. Fungal biofilms should be considered as a cause for treatment failure and fungal persistence, especially when artificial prostheses or indwelling catheters are present.
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Coccidioides immitis has been reported to form biofilms on medical devices.
“Although rare, C. immitis has been reported to form biofilms on medical devices (40).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [40]
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<i>Candida albicans</i> Biofilms and Human Disease
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- Authors
- Davis, L. E., Cook, G., & Costerton, J. W.
- Affiliations
- University of New Mexico (US)
- Montana State University (US)
- Corresponding author
- Davis, Larry E.
- Venue
- Emerging Infectious Diseases
- Published
- 2002-04
- Volume
- 8
- Issue
- 4
- Pages
- 376-379
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- PMC
- PMC2730244
- OpenAlex
- W2038824708
- Cited by
- 86
- References
- 15
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Emerging infectious diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- coccidioidal meningitis, Coccidioides immitis, fungal biofilms, ventriculoperitoneal shunt, recurrent meningitis, treatment failure, fluconazole, fungal persistence, indwelling catheter, prosthesis
- MeSH terms
- Antifungal Agents, Coccidioides, Coccidioidomycosis, Equipment Contamination, Humans, Male, Middle Aged, Fluconazole, Meningitis, Fungal, Treatment Failure, Ventriculoperitoneal Shunt, Biofilms
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