The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast
Open accessAbstract
Cryptococcal meningitis is common in sub-Saharan Africa. Given the need for data for a rapid, point-of-care cryptococcal antigen (CRAG) lateral flow immunochromatographic assay (LFA), we assessed diagnostic performance of cerebrospinal fluid (CSF) culture, CRAG latex agglutination, India ink microscopy, and CRAG LFA for 832 HIV-infected persons with suspected meningitis during 2006-2009 (n = 299) in Uganda and during 2010-2012 (n = 533) in Uganda and South Africa. CRAG LFA had the best performance (sensitivity 99.3%, specificity 99.1%). Culture sensitivity was dependent on CSF volume (82.4% for 10 μL, 94.2% for 100 μL). CRAG latex agglutination test sensitivity (97.0%-97.8%) and specificity (85.9%-100%) varied between manufacturers. India ink microscopy was 86% sensitive. Laser thermal contrast had 92% accuracy (R = 0.91, p<0.001) in quantifying CRAG titers from 1 LFA strip to within <1.5 dilutions of actual CRAG titers. CRAG LFA is a major advance for meningitis diagnostics in resource-limited settings.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660
Park, B. J., Wannemuehler, K. A., Marston, B. J., Govender, N., Pappas, P. G., & Chiller, T. M. (2009) · AIDS · doi:10.1097/qad.0b013e328322ffac · Cited by 2,014
Kaplan, J. E., Benson, C., Holmes, K. K., Brooks, J. T., Pau, A., & Masur, H. (2009) · PsycEXTRA Dataset · doi:10.1037/e537722009-001 · Cited by 1,343
Prognostic Factors in Cryptococcal Meningitis: A Study in 111 Cases
DIAMOND, R. D., & BENNETT, J. E. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-176 · Cited by 605
Evaluation of diagnostic tests when there is no gold standard. A review of methods
Rutjes, A., Reitsma, J., Coomarasamy, A., Khan, K., & Bossuyt, P. (2007) · Health Technology Assessment · doi:10.3310/hta11500 · Cited by 524
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
Brouwer, A. E., Rajanuwong, A., Chierakul, W., Griffin, G. E., Larsen, R. A., White, N. J., & Harrison, T. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16301-0 · Cited by 470
Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults
French, N., Gray, K., Watera, C., Nakiyingi, J., Lugada, E., Moore, M., Lalloo, D., Whitworth, J. A. G., & Gilks, C. F. (2002) · AIDS · doi:10.1097/00002030-200205030-00009 · Cited by 417
Bicanic, T., & Harrison, T. S. (2004) · British Medical Bulletin · doi:10.1093/bmb/ldh043 · Cited by 361
Jarvis, J. N., Lawn, S. D., Vogt, M., Bangani, N., Wood, R., & Harrison, T. S. (2009) · Clinical Infectious Diseases · doi:10.1086/597262 · Cited by 318
Kambugu, A., Meya, D. B., Rhein, J., O’Brien, M., Janoff, E. N., Ronald, A. R., Kamya, M. R., Mayanja‐Kizza, H., Sande, M. A., Bohjanen, P. R., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587667 · Cited by 300
Self-citation
Research works printed but not linked: 2
- Jarvis, 2012, Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation., J Int Assoc Physicians AIDS Care (Chic), 11, 374, 10.1177/1545109712459077 · doi:10.1177/1545109712459077
- Gates-Hollingsworth, 2013, Serotype sensitivity of a lateral flow immunoassay for cryptococcal antigen., Clin Vaccine Immunol, 20, 634, 10.1128/CVI.00732-12 · doi:10.1128/cvi.00732-12
Cited by
Ultrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis
Liu, Y., Zhan, L., Qin, Z., Sackrison, J., & Bischof, J. C. (2021) · ACS Nano · doi:10.1021/acsnano.0c10035 · Cited by 626
Self-citationMethods for Rapid Diagnosis of Meningitis Etiology in Adults
Poplin, V., Boulware, D. R., & Bahr, N. C. (2020) · Biomarkers in Medicine · doi:10.2217/bmm-2019-0333 · Cited by 119
Self-citationParkes‐Ratanshi, R., Achan, B., Kwizera, R., Kambugu, A., Meya, D., & Denning, D. W. (2015) · Mycoses · doi:10.1111/myc.12387 · Cited by 49
Self-citationMeya, D. B., Kiragga, A. N., Nalintya, E., Morawski, B. M., Rajasingham, R., Park, B. J., Mubiru, A., Kaplan, J. E., Manabe, Y. C., Boulware, D. R., et al. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001894 · Cited by 47
Self-citationState-of-the-Art Microbiologic Testing for Community-Acquired Meningitis and Encephalitis
Polage, C. R., & Cohen, S. H. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00289-16 · Cited by 43
Metadata
- Authors
- Boulware, D. R., Rolfes, M. A., Rajasingham, R., von Hohenberg, M., Qin, Z., Taseera, K., Schutz, C., Kwizera, R., Butler, E. K., Meintjes, G., Muzoora, C., Bischof, J. C., & Meya, D. B.
- Venue
- Emerging Infectious Diseases
- Published
- 2014-01
- Volume
- 20
- Issue
- 1
- Pages
- 45-53
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W1976256249
- Cited by
- 321
- References
- 34
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast. https://app.cochat.ai/papers/10.3201/eid2001.130906
- The paper
- Boulware, D. R., Rolfes, M. A., Rajasingham, R., von Hohenberg, M., Qin, Z., Taseera, K., Schutz, C., Kwizera, R., Butler, E. K., Meintjes, G., Muzoora, C., Bischof, J. C., & Meya, D. B. (2014). Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast. Emerging Infectious Diseases. https://doi.org/10.3201/eid2001.130906
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.