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Cited by 227SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Outbreaks Research

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015

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Choe, Pyoeng Gyun, Perera, R.A.P.M., Park, Wan Beom, Song, Kyoung-Ho, Bang, Ji Hwan, Kim, Eu Suk, Kim, Hong Bin, Ko, Long Wei Ronald, Park, Sang Won, Kim, Nam-Joong, Lau, Eric H.Y., Poon, Leo L.M., Peiris, Malik, Oh, Myoung-don·2017·Emerging Infectious Diseases
DOI 10.3201/eid2307.170310PMC PMC5512479
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Abstract

We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging.

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Crossref · 10.3201/eid2307.170310

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Figure Middle East respiratory syndrome (MERS) coronavirus antibody titers in serially collected serum samples from 11 patients with reverse transcription PCR–confirmed symptomatic MERS, South Korea, 2015. PRNT90 titers (A) and MERS spike protein (S1) ELISA OD ratios (B) were determined at multiple time points 0 to >400 days after disease onset. The limit of detection was 10 for the PRNT, and the cutoff between negative and borderline samples for the S1 ELISA was an OD ratio of 0.8. Letters in key indicate patients; red indicates those with severe disease, and green indicates those with nonsevere disease. OD, optical density; PRNT90, >90% plaque-reduction neutralization test.
Figure Middle East respiratory syndrome (MERS) coronavirus antibody titers in serially collected serum samples from 11 patients with reverse transcription PCR–confirmed symptomatic MERS, South Korea, 2015. PRNT90 titers (A) and MERS spike protein (S1) ELISA OD ratios (B) were determined at multiple time points 0 to >400 days after disease onset. The limit of detection was 10 for the PRNT, and the cutoff between negative and borderline samples for the S1 ELISA was an OD ratio of 0.8. Letters in key indicate patients; red indicates those with severe disease, and green indicates those with nonsevere disease. OD, optical density; PRNT90, >90% plaque-reduction neutralization test.CC BY · PubMed Central

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Metadata

Authors
Choe, P. G., Perera, R. A. P. M., Park, W. B., Song, K.-H., Bang, J. H., Kim, E. S., Kim, H. B., Ko, L. W. R., Park, S. W., Kim, N.-J., Lau, E. H. Y., Poon, L. L. M., Peiris, M., & Oh, M.-D.
Affiliations
Seoul National University (KR)
Corresponding author
Oh, Myoung-don
ORCID
Venue
Emerging Infectious Diseases
Publisher
Centers for Disease Control and Prevention (CDC)
Published
2017-07
Volume
23
Issue
7
Pages
1079-1084
ISSN
  • 1080-6040 (ISSN-L)
  • 1080-6059
DOI
10.3201/eid2307.170310
PMC
PMC5512479
OpenAlex
W2612594162
Cited by
227
References
17
Citations by year
2026: 7 · 2025: 3 · 2024: 8 · 2023: 12 · 2022: 21 · 2021: 60 · 2020: 91 · 2019: 13 · 2018: 7 · 2017: 5
FWCI
24.63
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Emerging infectious diseases (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • Seoul National University
  • Korea Health Industry Development Institute (HI15C3227)
  • Seoul National University Hospital
  • Hong Kong Government
  • National Institutes of Health
  • Health and Medical Research Fund
  • National Institute of Allergy and Infectious Diseases (HHSN272201400003C)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords
MERS-CoV, neutralizing antibodies, spike protein antibodies, antibody kinetics, antibody waning, seroconversion, convalescent plasma
MeSH terms
Antibodies, Viral, Disease Outbreaks, Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Humans, Neutralization Tests, Seroepidemiologic Studies, Coronavirus Infections, History, 21st Century, Republic of Korea, Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus, Middle East Respiratory Syndrome Coronavirus

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