Human Brain Networks in Cognitive Decline: A Graph Theoretical Analysis of Cortical Connectivity from EEG Data
Abstract
The aim of this study was to investigate the neuronal network characteristics in physiological and pathological brain aging. A database of 378 participants divided in three groups was analyzed: Alzheimer's disease (AD), mild cognitive impairment (MCI), and normal elderly (Nold) subjects. Through EEG recordings, cortical sources were evaluated by sLORETA software, while graph theory parameters (Characteristic Path Length λ, Clustering coefficient γ, and small-world network σ) were computed to the undirected and weighted networks, obtained by the lagged linear coherence evaluated by eLORETA software. EEG cortical sources from spectral analysis showed significant differences in delta, theta, and alpha 1 bands. Furthermore, the analysis of eLORETA cortical connectivity suggested that for the normalized Characteristic Path Length (λ) the pattern differences between normal cognition and dementia were observed in the theta band (MCI subjects are find similar to healthy subjects), while for the normalized Clustering coefficient (γ) a significant increment was found for AD group in delta, theta, and alpha 1 bands; finally, the small world (σ) parameter presented a significant interaction between AD and MCI groups showing a theta increase in MCI. The fact that AD patients respect the MCI subjects were significantly impaired in theta but not in alpha bands connectivity are in line with the hypothesis of an intermediate status of MCI between normal condition and overt dementia.
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Neurodegenerative diseases are usually characterized by a significant reduction in network connectivity, and cortical EEG-FC reflects the intensity of information flow among involved cortical regions.
“Neurodegenerative diseases are usually characterized by a significant reduction in network connectivity, and cortical EEG-FC reflects the intensity of information flow among involved cortical regions [57-59].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [57]
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Small-World Characteristics of Cortical Connectivity Changes in Acute Stroke
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Cortical connectivity modulation during sleep onset: A study via graph theory on EEG data
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Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue
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Self-citationAltered resting-state EEG complexity in children with Tourette syndrome: A preliminary study.
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Cortical Brain Connectivity and B-Type Natriuretic Peptide in Patients With Congestive Heart Failure
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Weighted Brain Network Analysis on Different Stages of Clinical Cognitive Decline
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Resting-state electroencephalographic characteristics related to mild cognitive impairments
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Pre-seizure architecture of the local connections of the epileptic focus examined via graph-theory
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tDCS effects on brain network properties during physiological aging
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Complexity analysis from EEG data in congestive heart failure: A study via approximate entropy
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APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer’s disease spectrum
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- Authors
- Vecchio, F., Miraglia, F., Marra, C., Quaranta, D., Vita, M. G., Bramanti, P., & Rossini, P. M.
- Affiliations
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Università Cattolica del Sacro Cuore (IT)
- Centro Neurolesi Bonino Pulejo (IT)
- Corresponding author
- Vecchio, Fabrizio
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2014-06-04
- Volume
- 41
- Issue
- 1
- Pages
- 113-127
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1488022810
- Cited by
- 182
- References
- 80
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 12 · 2023: 10 · 2022: 22 · 2021: 17 · 2020: 18 · 2019: 16 · 2018: 16 · 2017: 15 · 2016: 15 · 2015: 10 · 2014: 7
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- Alzheimer's disease, mild cognitive impairment
- MeSH terms
- Aged, Alpha Rhythm, Alzheimer Disease, Brain, Brain Mapping, Cerebral Cortex, Delta Rhythm, Electroencephalography, Female, Humans, Male, Neural Pathways, Signal Processing, Computer-Assisted, Software, Theta Rhythm, Cognitive Dysfunction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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