EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease
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Objective: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson’s disease (PD). METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis it was used the synchronization likelihood (SL) and graph theory (GT). RESULTS: PD-MCI patients showed decreased FC in frequencies alpha, in posterior regions, and delta with a generalized distribution. Patients, compared to the healthy people, presented a decrease in segregation (lower clustering coefficient in alpha p = 0.003 in PD-MCI patients) and increased integration (shorter mean path length in delta (p = 0.004) and theta (p = 0.002) in PD-MCI patients). There were no significant differences in the network topology between the parkinsonian groups. In PD-MCI patients, executive dysfunction correlated positively with global connectivity in beta (r = 0.47) and negatively with the mean path length at beta (r = −0.45); alterations in working memory were negatively correlated with the mean path length at beta r = −0.45. CONCLUSIONS: PD patients present alterations in the FC in all frequencies, those with MCI show less connectivity in the alpha and delta frequencies. The neural networks of the patients show a random topology, with a similar organization between patients with and without MCI. In PD-MCI patients, alterations in executive function and working memory are related to beta integration.
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Alterations in brain FC may precede structural damage and might be a key marker in detecting changes in brain plasticity over short periods in some neurodegenerative diseases.
“Alterations in the brain FC may precede structural damage and might be a key marker in detecting changes in brain plasticity over short periods in some neurodegenerative diseases [30-32].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [31]
Compared with healthy people, patients with PD without cognitive impairment showed decreased EEG-FC in the alpha and theta frequencies, while those with PD with mild cognitive impairment showed decreased EEG-FC in alpha in posterior distribution, and delta frequency with a generalized distribution.
“Compared with healthy people, patients with PD without cognitive impairment showed a decrease EEG-FC in the alpha and theta frequencies, while those with PD with mild cognitive impairment showed decreased EEG-FC in alpha in posterior distribution, and delta frequency with a generalized distribution [60].”
From QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis (2023) · cites this paper as [60]
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- Authors
- Peláez Suárez, A. A., Berrillo Batista, S., Pedroso Ibáñez, I., Casabona Fernández, E., Fuentes Campos, M., & Chacón, L. M.
- Affiliations
- Movement Disorders and Neurodegeneration Clinic, International Center for Neurological Restoration, Playa, Havana 11300, Cuba
- Department of Clinical Neurophysiology, International Center for Neurological Restoration, Playa, Havana 11300, Cuba
- Polyclinic “28 de Enero”, Playa, Havana 11300, Cuba
- Venue
- Behavioral Sciences
- Publisher
- MDPI AG
- Published
- 2021-03-23
- Volume
- 11
- Issue
- 3
- Pages
- 40
- ISSN
- 2076-328X (ISSN-L)
- PMC
- PMC8005012
- OpenAlex
- W3136907916
- Cited by
- 27
- References
- 38
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 3
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Behavioral Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, mild cognitive impairment, EEG functional connectivity, synchronization likelihood, graph theory, brain network topology, alpha band, delta band, beta band, clustering coefficient, average path length, executive dysfunction, working memory, cognitive impairment
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