Mild cognitive impairment in the elderly: Predictors of dementia

Flicker, Charles; Ferris, Steven H.; Reisberg, Barry

doi:10.1212/wnl.41.7.1006

Cited by 840Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesHistorical and Modern Theater Studies

Mild cognitive impairment in the elderly: Predictors of dementia

Flicker, Charles, Ferris, Steven H., Reisberg, Barry·1991·Neurology

DOI 10.1212/wnl.41.7.1006

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Abstract

We conducted full diagnostic evaluations, including a comprehensive cognitive assessment battery, of a group of 32 elderly subjects with a clinically identified mild cognitive impairment and a group of 32 age-matched and education-matched normal subjects. The mildly impaired subjects performed significantly more poorly than the controls on tests of recent memory, remote memory, language function, concept formation, and visuospatial praxis. Follow-up evaluations of cognitive status 2 years later revealed clinically detectable cognitive decline relative baseline in 23 (72%) of the mildly impaired subjects. Several of the objective psychological tests accurately discriminated at baseline between the decliners and nondecliners in the mildly impaired group. Among the 20 mildly impaired subjects with no complicating conditions, 16 exhibited cognitive deterioration between baseline and follow-up. These results suggest that most elderly subjects with mild cognitive deficits, as determined by clinical evaluation and objective psychological testing, will manifest the progressive mental deterioration characteristic of dementia and that psychometric predictors can be used to distinguish between benign and more significant underlying disorders in mildly impaired elderly subjects.

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The intermediate state between normal cognition and Alzheimer's disease has been termed mild cognitive impairment (MCI), and clinical criteria for this diagnosis have been suggested.
“This intermediate state has been termed mild cognitive impairment (MCI) and clinical criteria for this diagnosis have been suggested(1–3).”
From Rates of hippocampal atrophy correlate with change in clinical status in aging and AD (2000) · cites this paper as [3]

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Authors: Flicker, C., Ferris, S. H., & Reisberg, B.
Affiliations: NYU Langone Health (US)
ORCID: Ferris, Steven H.
Reisberg, Barry
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1991-07
Volume: 41
Issue: 7
Pages: 1006-1006
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.41.7.1006
OpenAlex: W2008180577
Cited by: 838
References: 0
Citations by year: 2026: 4 · 2025: 13 · 2024: 14 · 2023: 14 · 2022: 10 · 2021: 18 · 2020: 24 · 2019: 28 · 2018: 19 · 2017: 18 · 2016: 21 · 2015: 32 · 2014: 23 · 2013: 28 · 2012: 31
FWCI: 7.48
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh040410-02)
National Institute on Aging (AG03051, R01AG003051)
National Institute of Mental Health (MH 40410)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords: mild cognitive impairment, older adults, cognitive decline, dementia, memory impairment, language functions, concept formation, cognitive assessment, longitudinal follow-up
MeSH terms: Aged, Aging, Cognition Disorders, Dementia, Humans, Longitudinal Studies, Neuropsychological Tests, Prognosis, Psychiatric Status Rating Scales

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Mild cognitive impairment in the elderly: Predictors of dementia

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