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Cannabis Phytochemicals: A Review of Phytocannabinoid Chemistry and Bioactivity as Neuroprotective Agents

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Neurovascular Dysfunction in Diverse Communities With Health Disparities—Contributions to Dementia and Alzheimer’s Disease

Saiyasit, N., Butlig, E.-A. R., Chaney, S. D., Traylor, M. K., Hawley, N. A., Randall, R. B., Bobinger, H. V., Frizell, C. A., Trimm, F., Crook, E. D., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.915405 · Cited by 21 · see citing works

Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2 receptor antagonists/inverse agonists

Dore, A., Asproni, B., Scampuddu, A., Gessi, S., Murineddu, G., Cichero, E., Fossa, P., Merighi, S., Bencivenni, S., & Pinna, G. A. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.08.055 · Cited by 19 · see citing works

Interaction of Cannabis Use and Aging: From Molecule to Mind

Yoo, H. B., DiMuzio, J. M., & Filbey, F. M. (2019) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1665218 · Cited by 19 · see citing works

A Comprehensive Exploration of the Multifaceted Neuroprotective Role of Cannabinoids in Alzheimer’s Disease across a Decade of Research

Tyrakis, P., Agridi, C., & Kourti, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168630 · Cited by 19 · see citing works

Evaluating Cannabis sativa L.'s neuroprotection potential: From bench to bedside.

Laws, J. S., & Smid, S. D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154485 · Cited by 14 · see citing works

Δ8-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis

Gugliandolo, A., Blando, S., Salamone, S., Caprioglio, D., Pollastro, F., Mazzon, E., & Chiricosta, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076598 · Cited by 17 · see citing works

Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility

Kichloo, A., Albosta, M. S., Aljadah, M. M., El‐amir, Z., Goldar, G., Khan, M. Z., Dahiya, D. S., Vallabhaneni, S., Wani, F., & Singh, J. (2021) · SAGE Open Medicine · doi:10.1177/20503121211000909 · Cited by 17 · see citing works

Destabilization of the Alzheimer’s amyloid-β protofibrils by THC: A molecular dynamics simulation study

Kanchi, P. K., & Dasmahapatra, A. K. (2021) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2021.107889 · Cited by 16 · see citing works

Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan)

Palmieri, B., Laurino, C., & Vadalà, M. (2019) · International Journal of Pharmacy Practice · doi:10.1111/ijpp.12514 · Cited by 16 · see citing works

A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment

Licitra, R., Marchese, M., Naef, V., Ogi, A., Martinelli, M., Kiferle, C., Fronte, B., & Santorelli, F. M. (2022) · Biomedicines · doi:10.3390/biomedicines10081820 · Cited by 15 · see citing works

Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease

Montero, J. M. S., Agís-Torres, Á., Solano, D., Söllhuber, M. M., Fernandez, M., Villaro, W., Gómez‐Cañas, M., Garcı́a-Arencibia, M., Fernández‐Ruíz, J., Egea, J., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173875 · Cited by 14 · see citing works

Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats

Halbout, B., Hutson, C., Hua, L., Inshishian, V. C., Mahler, S. V., & Ostlund, S. B. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06352-4 · Cited by 14 · see citing works

Whole Organisms or Pure Compounds? Entourage Effect Versus Drug Specificity

Ribeiro, S. T. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-76720-8_8 · Cited by 14 · see citing works

Synthesis and biological evaluation of (3′,5′-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist

Presley, C. S., Mustafa, S. M., Abidi, A. H., & Moore, B. M., II (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.07.057 · Cited by 14 · see citing works

Cannabinoid Therapeutics in Parkinson’s Disease: Promise and Paradox

Turner, H. C., Chueh, D., Ortiz, T., Stokes, A. J., & Small-Howard, A. L. (2017) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496475.2017.1312724 · Cited by 13 · see citing works

Phytochemical and biological research of Cannabis pharmaceutical resources

Hao, D., Gu, X.-J., & Xiao, P. G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-100085-4.00011-6 · Cited by 12 · see citing works

The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC

Fihurka, O., Hong, Y., Yan, J., Brown, B., Lin, X., Shen, N., Wang, Y., Zhao, H., Gordon, M. N., Morgan, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084253 · Cited by 11 · see citing works

Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease

Arnanz, M. A., Esteban, S. R. D. M., Martínez-Relimpio, A. M., Rimmerman, N., Zaks, N., Grande, M. T., & Romero, J. (2023) · Cannabis and Cannabinoid Research · doi:10.1089/can.2023.0101 · Cited by 11 · see citing works

Receptor Targets in Alzheimer’s Disease Drug Discovery

Wallach, J. V., Colestock, T., & Adejare, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00006-4 · Cited by 11 · see citing works

Women are taking the hit: Examining the unique consequences of cannabis use across the female lifespan

Gräfe, E. L., Reid, H. M. O., Shkolnikov, I., Conway, K., Kit, A., Acosta, C., & Christie, B. R. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101076 · Cited by 10 · see citing works

Combinatorial Treatment Effects in a Cell Culture Model of Alzheimer’s Disease

Beesley, S., Olcese, J., Saunders, C. E., & Bienkiewicz, E. A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160459 · Cited by 10 · see citing works

Cannabinoid pharmacology and its therapeutic uses in Alzheimer’s disease

Monteiro, K. L. C., Alcântara, M. G. D. S., de Aquino, T. M., & da Silva‐Júnior, E. F. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.294336 · Cited by 9 · see citing works

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

Sharon, N., Yarmolinsky, L., Khalfin, B., Fleisher‐Berkovich, S., & Ben‐Shabat, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126402 · Cited by 9 · see citing works

Anticancer activity of Δ9-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft

Leelawat, S., Leelawat, K., Wannakup, T., Saingam, W., Khamthong, N., Madaka, F., Maha, A., Pathompak, P., Sueree, L., & Songsak, T. (2022) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.350180 · Cited by 8 · see citing works

Oral Thc: Cbd Cannabis Extract in Main Symptoms of Alzheimer Disease: Agitation and Weight LossPreprint

Palmieri, B., & Vadalà, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1672277/v1 · Cited by 8 · see citing works

EFFECTS OF RIMONABANT ON ACTIVE AVOIDANCE LEARNING IN BULBECTOMIZED RATS

Velikova, M., Doncheva, D., & Tashev, R. E. (2020) · Journal of IMAB - Annual Proceeding (Scientific Papers) · doi:10.5272/jimab.2020261.2936 · Cited by 7 · see citing works

A Review of On the Psychobiological Differences among Tetrahydrocannabinol, Cannabinol, Cannabidiol and Cannabigerol

Messina, G., Rovelli, F., & Lissoni, P. (2022) · Clinical Reviews & Cases · doi:10.33425/2689-1069.1040 · Cited by 6 · see citing works

Substances of Health Concern: Label Accuracy of Cannabidiol and Tetrahydrocannabinol in Commercial Cannabidiol Tinctures from the United States

Sullivan, Z., Lapierre, C., Erlandson, L. W., & Pham, L. (2025) · Cannabis and Cannabinoid Research · doi:10.1089/can.2025.0016 · Cited by 4 · see citing works

Alzheimer's Disease and the Immune System

Cao, C. (2015) · SOJ Neurology · doi:10.15226/2374-6858/2/1/00112 · Cited by 5 · see citing works

Neuroprotective effects of G9a inhibition and cannabinoid receptor activation in Alzheimer's disease through a pharmacological approach

Bellver‐Sanchís, A., Ribalta‐Vilella, M., Lillo, J., Ortuño‐Sahagún, D., Franco, R., Pallàs, M., Navarro, G., & Griñán‐Ferré, C. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00616 · Cited by 4 · see citing works

Cannabidiolic Acid Rescues Deficits in Hippocampal Long-Term Potentiation in Models of Alzheimer’s Disease: An Electrophysiological and Proteomic Analysis

Gil, B., Sullivan, M., Scaife, C., Glennon, J. C., & Herron, C. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104944 · Cited by 3 · see citing works

The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects

Zeng, A., Quan, Y., Tao, H., Dai, Y., Song, L., & Zhao, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083561 · Cited by 3 · see citing works

The Endocannabinoid System in Local and Systemic Inflammation

Kelly, M. E. M., Lehmann, C., & Zhou, J. (2017) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00151ed1v01y201702isp074 · Cited by 3 · see citing works

Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations

Peng, Q., Wilhelmsen, K. C., & Ehlers, C. L. (2022) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103852 · Cited by 3 · see citing works

Commentary: Navigating the complexities of marijuana

Weiss, S. R. B., & Wargo, E. M. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.06.026 · Cited by 3 · see citing works

Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis UsersPreprint

Clark, T. M., Jones, J. M., Hall, A. G., Tabner, S. A., & Kmiec, R. L. (2018) · Preprints.org · doi:10.20944/preprints201807.0197.v1 · Cited by 3 · see citing works

β‐Caryophyllene Ameliorates STZ‐Induced Alzheimer's Disease‐Like Conditions in Rats via Modulation of Brain‐Derived Neurotrophic Factor, Synaptic Plasticity, and Neuroinflammation

Rathod, S., & Agrawal, Y. O. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70317 · Cited by 2 · see citing works

Cannabinoids Treatment for Agitation in Alzheimer’s Disease: A Systematic Review and Meta-Analysis With Bayesian and Sequential Trial Analyses

da Silva, A. M. P., Lima, D. D. S., Souza, R. F., Lopes, V. H. P., Cardoso, L. J. C., Pinto, E. L. O., Gonçalves, O. R., Braga, C., Cal, H., Santos, D. H., et al. (2026) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2026.05.016 · Cited by 2 · see citing works

The therapeutic effect of the oily extract of Cannabis sp. in Aluminum Chloride-Induced Alzheimer's Disease in Rats

da Silva, R. N., Dias, F. C. R., de Torres, S. M., Silva, A. A. D. N., Alves, A. D. D. F., Alves, A. J., & da Silva, V. A. (2024) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e14270.2024 · Cited by 2 · see citing works

Effects of chronic Δ 9 -tetrahydrocannabinol treatment on Rho/Rho-kinase signalization pathway in mouse brain

Kaplan, H. M., & Pazarcı, P. (2017) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2017.05.002 · Cited by 2 · see citing works

Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease

Fu, C.-L., Li, X., Liu, X., Zheng, Y., Ma, X., Zhang, B., Chen, S. X., Hu, L., Su, S., Wang, X., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00498-1 · Cited by 2 · see citing works

Perioperative Repercussions of Cannabis Use—Implications for GI Endoscopy Sedation

Goudra, B., & Green, M. S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14197028 · Cited by 1 · see citing works

Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review

Ntsapi, C., Weyers, M., Chinheya, R. M., Jim, T., & Matsabisa, M. G. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1748368 · Cited by 1 · see citing works

Cannabidiol and epilepsy: therapeutic, mechanistic and clinical significance

Gupta, N., Maan, P., Shrivastava, J., & Ansari, M. H. R. (2026) · Seizure · doi:10.1016/j.seizure.2026.06.014 · Cited by 1 · see citing works

PLANTAS MEDICINAIS E FITOTERÁPICOS

Inovar, E. (2022) · Editora Inovar eBooks · doi:10.36926/editorainovar-978-65-80476-95-4 · Cited by 1 · see citing works

Research impact in randomized controlled trials of diabetes: an altmetric approach

Sedghi, S., Abouhamzeh, K., Dokhani, F., Delavari, S., Soltani, A., Soleimanpour, S., Nemati‐Anaraki, L., & Aletaha, A. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01287-1 · Cited by 1 · see citing works

Phytocannabinoids: a new frontier in Alzheimer’s disease management

Rao, J. S. (2024) · Academia Biology · doi:10.20935/acadbiol7344 · Cited by 1 · see citing works

Endocannabinoids and Alzheimer's disease

Chen, C. (2025) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-443-13908-6.00026-8 · Cited by 1 · see citing works

Cannabis (Marijuana) and Cannabinoids

Upton, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00061-3 · Cited by 1 · see citing works

Dementia: Alzheimer’s Disease

O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_9 · Cited by 1 · see citing works

Medicinal Cannabis for Alzheimer's Disease

Steiner, G. Z., Coles, M., Jaye, K. M., Metri, N., Butt, A. S., Christofides, K., McPartland, J., Al-Modhefer, Z., Karamacoska, D., Russo, E. B., et al. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5652-1.ch001 · Cited by 1 · see citing works

Extreme low dose THC as a therapeutic and prophylactic agent for Alzheimer's disease

Cao, C. (2022) · Digital Commons - University of South Florida (University of South Florida)

An ultra-low dose of Δ9-tetrahydrocannabinol improves Alzheimer’s Disease-related cognitive deficitsPreprint

Nitzan, K., Ellenbogen, L., Beniamin, T., Sarne, Y., & Doron, R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.22.457252 · Cited by 1 · see citing works

A Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology

Eubanks, L. M., Rogers, C. J., Beuscher, Koob, G. F., Olson, A. J., Dickerson, T. J., & Janda, K. D. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060066m · Cited by 270 · see citing works

Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice

Wang, Y., Hong, Y., Yan, J., Brown, B., Lin, X., Zhang, X., Shen, N., Li, M., Cai, J., Gordon, M. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052757 · Cited by 22 · see citing works

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice

Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R., & Ferrer, I. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141014 · Cited by 154 · see citing works