Cited by 154Alzheimer's disease research and treatmentsCannabis and Cannabinoid ResearchMedicinal Plants and Neuroprotection

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice

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Aso, Ester, Sánchez-Pla, Alexandre, Vegas-Lozano, Esteban, Maldonado, Rafael, Ferrer, Isidro·2014·Journal of Alzheimer s Disease

Abstract

Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanical extracts, as well as the combination of both natural cannabinoids, which are the components of an already approved cannabis-based medicine, preserved memory in AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage. Moreover, THC + CBD reduced learning impairment in AβPP/PS1 mice. A significant decrease in soluble Aβ42 peptide levels and a change in plaques composition were also observed in THC + CBD-treated AβPP/PS1 mice, suggesting a cannabinoid-induced reduction in the harmful effect of the most toxic form of the Aβ peptide. Among the mechanisms related with these positive cognitive effects, the anti-inflammatory properties of cannabinoids may also play a relevant role. Here we observed reduced astrogliosis, microgliosis, and inflammatory-related molecules in treated AβPP/PS1 mice, which were more marked after treatment with THC + CBD than with either THC or CBD. Moreover, other cannabinoid-induced effects were uncovered by a genome-wide gene expression study. Thus, we have identified the redox protein thioredoxin 2 and the signaling protein Wnt16 as significant substrates for the THC + CBD-induced effects in our AD model. In summary, the present findings show that the combination of THC and CBD exhibits a better therapeutic profile than each cannabis component alone and support the consideration of a cannabis-based medicine as potential therapy against AD.

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Authors
Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R., & Ferrer, I.
Affiliations
  • Bellvitge University Hospital (ES)
  • Departament d'Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
  • Universitat Pompeu Fabra (ES)
  • Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain
Corresponding author
Aso, Ester
Venue
Journal of Alzheimer s Disease
Published
2014-12-02
Volume
43
Issue
3
Pages
977-991
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1528275131
Cited by
154
References
48
Citations by year
2026: 8 · 2025: 11 · 2024: 23 · 2023: 12 · 2022: 23 · 2021: 13 · 2020: 11 · 2019: 17 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 2
FWCI
5.76
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Alzheimer's disease, cannabis-based medicines
MeSH terms
Alzheimer Disease, Animals, Brain, Gliosis, Learning, Memory, Mice, Transgenic, Amyloid beta-Peptides, Mice, Plaque, Amyloid, Medical Marijuana

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