Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice
Open accessAbstract
Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanical extracts, as well as the combination of both natural cannabinoids, which are the components of an already approved cannabis-based medicine, preserved memory in AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage. Moreover, THC + CBD reduced learning impairment in AβPP/PS1 mice. A significant decrease in soluble Aβ42 peptide levels and a change in plaques composition were also observed in THC + CBD-treated AβPP/PS1 mice, suggesting a cannabinoid-induced reduction in the harmful effect of the most toxic form of the Aβ peptide. Among the mechanisms related with these positive cognitive effects, the anti-inflammatory properties of cannabinoids may also play a relevant role. Here we observed reduced astrogliosis, microgliosis, and inflammatory-related molecules in treated AβPP/PS1 mice, which were more marked after treatment with THC + CBD than with either THC or CBD. Moreover, other cannabinoid-induced effects were uncovered by a genome-wide gene expression study. Thus, we have identified the redox protein thioredoxin 2 and the signaling protein Wnt16 as significant substrates for the THC + CBD-induced effects in our AD model. In summary, the present findings show that the combination of THC and CBD exhibits a better therapeutic profile than each cannabis component alone and support the consideration of a cannabis-based medicine as potential therapy against AD.
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In vivo studies using CBD and THC have shown enhanced memory in active avoidance and two-object recognition tasks.
“In vivo studies using CBD and THC have shown enhanced memory in the active avoidance and two-object recognition tasks [186].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [186]
Natural products such as cannabidiol (CBD) and tetrahydrocannabinol (THC) have shown to be effective in vitro and in vivo.
“Consequently, natural products, such as cannabidiol (CBD) and tetrahydrocannabinol (THC), have also shown to be effective in vitro and in vivo [184,185,186,187].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [186]
CBD/THC reduce soluble Abeta42 levels.
“Additionally, it has been shown to reduce soluble Abeta42 levels and alter the plaque composition [186].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [186]
CBD/THC alter plaque composition.
“Additionally, it has been shown to reduce soluble Abeta42 levels and alter the plaque composition [186].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [186]
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- Authors
- Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R., & Ferrer, I.
- Affiliations
- Bellvitge University Hospital (ES)
- Departament d'Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
- Universitat Pompeu Fabra (ES)
- Institut de Neuropatologia, Servei d'Anatomia Patològica, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain
- Corresponding author
- Aso, Ester
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2014-12-02
- Volume
- 43
- Issue
- 3
- Pages
- 977-991
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1528275131
- Cited by
- 154
- References
- 48
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 23 · 2023: 12 · 2022: 23 · 2021: 13 · 2020: 11 · 2019: 17 · 2018: 9 · 2017: 9 · 2016: 8 · 2015: 7 · 2014: 2
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, cannabis-based medicines
- MeSH terms
- Alzheimer Disease, Animals, Brain, Gliosis, Learning, Memory, Mice, Transgenic, Amyloid beta-Peptides, Mice, Plaque, Amyloid, Medical Marijuana
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