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Cited by 550Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsSex and Gender in Healthcare

Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer’s Disease

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Beam, Christopher R., Kaneshiro, Cody, Jang, Jung Yun, Reynolds, Chandra A., Pedersen, Nancy L., Gatz, Margaret·2018·Journal of Alzheimer’s Disease
DOI 10.3233/jad-180141PMC PMC6226313
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Abstract

In the following brief report, we examined gender differences in incidence rates of any dementia, Alzheimer’s disease (AD) alone, and non-Alzheimer’s dementia alone in 16,926 women and men in the Swedish Twin Registry aged 65+. Dementia diagnoses were based on clinical workup and national health registry linkage. Incidence rates of any dementia and AD were greater in women than men, with any dementia rates diverging after age 85 and AD rates diverging around 80. This pattern is consistent with women’s survival to older ages compared to men. These findings are similar to incidence rates reported in other Swedish samples.

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  • The observed female predominance is consistent with the known prevalence of AD in females.

    “Female donors outnumbered male donors (51 females, 33 males), particularly in those with high ADNC (29 females, 13 males), which is consistent with the known prevalence of AD in females38 (Fig. 1b, middle).”

    From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [38]

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  1. [1]Thies W, Bleiler L (2013) 2013 Alzheimer’s disease facts and figures. Alzheimers Dement 9, 208– 245. 23507120
  2. [2]Mielke MM, Vemuri P, Rocca WA (2014) Clinical epidemiology of Alzheimer’s disease: Assessing sex and gender differences. Clin Epidemiol 6, 37– 48. 24470773 PMC3891487
  3. [3]Altmann A, Tian L, Henderson VW, Greicius MD (2014) Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol 75, 563– 573. 24623176 PMC4117990
  4. [4]Rocca WA, Grossardt BR, Shusterd Lynne T (2014) Oophorectomy, estrogen, and dementia: A2014 update. Mol Cell Endocrinol 18, 1199– 1216. PMC4040304 24508665
  5. [5]Lin KA, Choudhury KR, Rathakrishnan BG, Marks DM, Petrella JR, Doraiswamy PM (2015) Marked gender differences in progression of mild cognitive impairment over 8 years. Alzheimers Dement (NY) 1, 103– 110. PMC4593067 26451386
  6. [6]Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC (2016) Sex biology contributions to vulnerability to Alzheimer’s disease: A think tank convened by the Women’s Alzheimer’s Research Initiative. Alzheimers Dement 12, 1186– 1196. 27692800 PMC10341380
  7. [7]Jorm AF, Jolley D (1998) The incidence of dementia: A meta-analysis. Neurology 51, 728– 733. 9748017
  8. [8]Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B (1997) Very old women at highest risk of dementia and Alzheimer’s disease: Incidence data from the Kungsholmen Project, Stockholm. Neurology 48, 132– 138. 9008508
  9. [9]Ott A (1998) Incidence and risk of dementia. Am J Epidemiol 147, 574– 580. 9521184
  10. [10]Letenneur L, Gilleron V, Commenges D, Helmer C, Orgogozo JM, Dartigues JF (1999) Are sex and educational level independent predictors of dementia and Alzheimer’s disease? Incidence data from the PAQUID project. J Neurol Neurosurg Psychiatry 66, 177– 183. 10071096 PMC1736218
  11. [13]Boothby H, Blizard R, Livingston G, Mann A (1994) The Gospel Oak Study stage III: The incidence of dementia. Psychol Med 24, 89– 95. 8208898
  12. [14]Bickel H, Cooper B (1994) Incidence and relative risk of dementia in an urban elderly population: Findings of a prospective field study. Psychol Med 24, 179– 192. 8208883
  13. [15]Morgan K, Lilley JM, Arie T, Byrne EJ, Jones R, Waite J (1993) Incidence of dementia in a representative British sample. Br J Psychiatry 163, 467– 470. 8252285
  14. [16]Brayne C, Gill C, Huppert FA, Barkley C, Gehlhaar E, Girling DM, DW OC, Paykel ES (1995) Incidence of clinically diagnosed subtypes of dementia in an elderly population. Br J Psychiatry 167, 255– 262. 7582679
  15. [17]Chene G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S (2015) Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimers Dement 11, 310– 320. 24418058 PMC4092061
  16. [18]Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, D’Agostino RB Sr (1997) Lifetime risk of dementia and Alzheimer’s disease: The impact of mortality on risk estimates in the Framingham Study. Neurology 49, 1498– 1504. 9409336
  17. [19]Zandi PP, Carlson MC, Plassman BL, Welsh-Bohmer KA, Mayer LS, Steffens DC, Breitner JC (2002) Hormone replacement therapy and incidence of Alzheimer disease in older women: The Cache County Study. J Am Med Assoc 288, 2123– 2129. 12413371
  18. [22]Kawas C, Gray S, Brookmeyer R, Fozard J, Zonderman A (2000) Age-specific incidence rates of Alzheimer’s disease: The Baltimore Longitudinal Study of Aging. Neurology 54, 2072– 2077. 10851365
  19. [23]Edland SD, Rocca WA, Petersen RC, Cha RH, Kokmen E (2002) Dementia and Alzheimer disease incidence rates do not vary by sex in Rochester, Minn. Arch Neurol 59, 1589– 1593. 12374497
  20. [24]Bachman DL, Wolf PA, Knoefel JE, Cobb JL, Belanger AJ, White LR (1993) Incidence of dementia and probable Alzheimer’s disease in a general population: The Framingham Study. Neurology 43, 515– 519. 8450993
  21. [25]Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, van Belle G, Jolley L, Larson EB (2002) Dementia and Alzheimer disease incidence. Arch Neurol 59, 1737– 1746. 12433261
  22. [26]Ruitenberg A, Ott A, Van Swieten JC, Hofman A, Breteler MMB (2001) Incidence of dementia: Does gender make a difference? Neurobiol Aging 22, 575– 580. 11445258
  23. [27]Hagnell O, Lanke J, Rorsman B, Ojesjo L (1981) Does the incidence of age psychosis decrease? Neuropsychobiology 7, 201. 7266826
  24. [28]Hagnell O, Ojesjo L, Rorsman B (1992) Incidence of dementia in the Lundby Study. Neuroepidemiology 11(Suppl 1), 61– 66. 1603251
  25. [29]Matthews FE, Stephan BCM, Robinson L, Jagger C, Barnes LE, Arthur A, Brayne C, Comas-Herrera A, Wittenberg R, Dening T, McCracke CFM, Moody C, Parry B, Green E, Barnes R, Warwick J, Gao L, Mattison A, Baldwin C, Harrison S, Woods B, McKeit IG, Ince PG, Wharton SB, Forster G (2016) A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies i and II. Nat Commun 7, 11398. 27092707 PMC4838896
  26. [30]Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C (2013) A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the cognitive function and ageing study i and II. Lancet 382, 1405– 1412. 23871492 PMC3906607
  27. [32]Gao S, Hendrie HC, Hall KS (1998) The relationships between age, sex, and the incidence of dementia and Alzheimer disease: A meta-analysis. Arch Gen Psychiatry 55, 809– 815. 9736007
  28. [33]Launer LJ, Andersen K, Dewey ME, Letenneur L, Ott A, Amaducci LA, Brayne C, Copeland JRM, Dartigues J-F, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A (1999) Rates and risk factors for dementia and Alzheimer’s disease: Results from EURODEM pooled analyses. Neurology 52, 78– 78. 9921852
  29. [35]Miech RA, Breitner JCS, Zandi PP, Khachaturian AS, Anthony JC, Mayer L (2002) Incidence of AD may decline in the early 90s for men, later for women: The Cache County study. Neurology 58, 209– 218. 11805246
  30. [36]Borenstein AR, Wu Y, Bowen JD, McCormick WC, Uomoto J, McCurry SM, Schellenberg GD, Larson EB (2014) Incidence rates of dementia, Alzheimer disease, and vascular dementia in the Japanese American population in Seattle, WA: The Kame Project. Alzheimer Dis Assoc Disord 28, 23– 29. 24045327 PMC4036673
  31. [37]Kawas CH (2008) The oldest old and the 90+ Study. Alzheimers Dement 4, S56– S59. 18632002 PMC3373258
  32. [38]Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E, Björk C, Svartengren M, Wolk A, Klareskog L, de Faire U, Schalling M, Palmgren J, Pedersen NL (2006) The Swedish Twin Registry in the third millennium: An update. Twin Res Hum Genet 9, 875– 882. 17254424
  33. [39]Järvenpää T, Rinne O, Räihä I (2002) Characteristics of two telephone. Dement Geriatr Cogn Disord 13, 149– 155. 11893836
  34. [41]Jin Y-P, Gatz M, Johansson B, Pedersen NL (2004) Sensitivity and specificity of dementia coding in two Swedish disease registries. Neurology 63, 739– 741. 15326258
  35. [42]Gatz M, Fratiglioni L, Johansson B, Berg S, Mortimer JA, Reynolds CA, Fiske A, Pedersen NL (2005) Complete ascertainment of dementia in the Swedish Twin Registry: The HARMONY study. Neurobiol Aging 26, 439– 447. 15653172
  36. [43]Rizzuto D, Feldman AL, Karlsson IK, Dahl Aslan AK, Gatz M, Pedersen NL (2018) Detection of dementia cases in two Swedish health registers: A validation study. J Alzheimers Dis 61, 1301– 1310. 29376854 PMC6218116

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Authors
Beam, C. R., Kaneshiro, C., Jang, J. Y., Reynolds, C. A., Pedersen, N. L., & Gatz, M.
Affiliations
  • University of Southern California (US)
  • University of California, Riverside (US)
Corresponding author
Beam, Christopher R.
ORCID
Venue
Journal of Alzheimer’s Disease
Publisher
SAGE Publications
Published
2018-06-27
Volume
64
Issue
4
Pages
1077-1083
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-180141
PMC
PMC6226313
OpenAlex
W2883094777
Cited by
550
References
9
Citations by year
2026: 84 · 2025: 119 · 2024: 102 · 2023: 69 · 2022: 57 · 2021: 74 · 2020: 38 · 2019: 7
FWCI
23.41
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG008724, T32AG000037)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords
gender differences, dementia incidence
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cross-Sectional Studies, Dementia, Female, Humans, Male, Sex Characteristics, Sweden, Cohort Studies, Incidence, Age of Onset

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