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Cited by 523Dementia and Cognitive Impairment ResearchAging and Gerontology ResearchAging, Health, and Disability

Dementia incidence continues to increase with age in the oldest old: The 90+ study

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Corrada, María M., Brookmeyer, Ron, Paganini‐Hill, Annlia, Berlau, Daniel, Kawas, Claudia H.·2010·Annals of Neurology
DOI 10.1002/ana.21915PMC PMC3385995
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Abstract

Objective: The oldest old are the fastest growing segment of the US population, and accurate estimates of dementia incidence in this group are crucial for healthcare planning. Although dementia incidence doubles every 5 years from ages 65 to 90 years, it is unknown if this exponential increase continues past age 90 years. Here, we estimate age‐ and sex‐specific incidence rates of all‐cause dementia in people aged 90 years and older, including estimates for centenarians. Methods: Participants are from The 90+ Study, a population‐based longitudinal study of aging and dementia. Three hundred thirty nondemented participants aged 90 years and older at baseline were followed between January 2003 and December 2007. Age‐ and sex‐specific incidence rates of all‐cause dementia were estimated by person‐years analysis. Results: The overall incidence rate of all‐cause dementia was 18.2% (95% confidence interval [CI], 15.3–21.5) per year and was similar for men and women (risk ratio, 0.94; 95% CI, 0.65–1.37). Rates increased exponentially with age from 12.7% per year in the 90–94‐year age group, to 21.2% per year in the 95–99‐year age group, to 40.7% per year in the 100+‐year age group. The doubling time based on a Poisson regression was 5.5 years. Interpretation: Incidence of all‐cause dementia is very high in people aged 90 years and older and continues to increase exponentially with age in both men and women. Projections of the number of people with dementia should incorporate this continuing increase of dementia incidence after age 90 years. Our results foretell the growing public health burden of dementia in an increasingly aging population. ANN NEUROL 2010;67:114–121

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  • The age-related increase in VaD follows the pattern of stroke, although dementia after stroke may be more frequent in people under 80 years old.

    “This age-related increase in VaD follows the pattern of stroke,269 although dementia after stroke may be more frequent in people <80 years old.270”

    From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [269]

    The Results report that all-cause dementia incidence increased with age among people aged 90 and older, and that 22% of examiner-diagnosed cases were vascular dementia. They do not report age-specific vascular dementia rates or compare their pattern with stroke. The separate claim about dementia after stroke in people under 80 is attached to citation 270, not this source. (LLM, conf=0.82)

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  • A recent review identified older age, lower education, prestroke cognitive impairment, diabetes, and atrial fibrillation as factors increasing risk, but second stroke was one of the strongest predictors of cognitive decline after initial stroke.

    “A recent review identified older age, lower education, prestroke cognitive impairment, diabetes, and atrial fibrillation as factors that increased the risk, but one of the strongest predictors of cognitive decline after an initial stroke was the occurrence of a second stroke.269,270”

    From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [269]

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  • In people with recurrent stroke, dementia risk rises to about 30%, regardless of number and severity of prior vascular risk factors.

    “In people with recurrent stroke, the risk of dementia rose to ≈30%, regardless of the number and severity of vascular risk factors they had been exposed to before the stroke.269”

    From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [269]

    The Discussion (page unavailable) reports no association between dementia and a history of stroke in this cohort of adults aged 90 or older. Our copy does not assess recurrent stroke, report a 30% dementia risk for that group, or compare risk by the number and severity of prior vascular risk factors; searches for those terms found no decisive passage. (LLM, conf=0.76)

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  • According to some studies, AD incidence and prevalence continuously increases with advancing age, reaching a point where a majority beyond a certain age likely have it.

    “According to some studies its incidence and prevalence continuously increases with advancing age, and appears to reach a point at which a majority of those beyond a certain age likely have it [3, 8, 12].”

    From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [12]

  • The incidence of dementia increases continually up to and above 90 years of age.

    “The incidence of dementia increases continually up to (179-183) and above (139, 184) 90 years of age.”

    From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [184]

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Authors
Corrada, M. M., Brookmeyer, R., Paganini‐Hill, A., Berlau, D., & Kawas, C. H.
Affiliations
  • University of California, Irvine (US)
  • Johns Hopkins University (US)
  • University of Southern California (US)
Corresponding author
Corrada, María M.
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2010-01
Volume
67
Issue
1
Pages
114-121
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.21915
PMC
PMC3385995
OpenAlex
W2116125119
Cited by
523
References
42
Citations by year
2026: 23 · 2025: 47 · 2024: 27 · 2023: 23 · 2022: 41 · 2021: 46 · 2020: 39 · 2019: 42 · 2018: 32 · 2017: 33 · 2016: 35 · 2015: 23 · 2014: 20 · 2013: 30 · 2012: 26
FWCI
12.15
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute on Aging (R01AG021055, T32AG000096)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
dementia incidence, oldest old, centenarians, age-specific incidence, sex differences, dementia projections
MeSH terms
Age Factors, Aged, 80 and over, California, Dementia, Educational Status, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Models, Biological, Psychiatric Status Rating Scales, Risk, Sex Factors, Incidence, Poisson Distribution

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