The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore
Abstract
We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0.23-0.78, p = 0.006) and this association was independent of age, gender, education, cigarette smoking, alcohol consumption, hypertension, diabetes, heart disease, stroke, physical activities, and social activities. Our cross-sectional data support the potential role of mushrooms and their bioactive compounds in delaying neurodegeneration.
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Ergothioneine is highly abundant in mushrooms and their consumption positively influences cognitive impairment in elderly people, confirming the importance of ergothioneine in healthy aging.
“Ergothioneine (see also above) is highly abundant in mushrooms and their consumption has been found to positively influence cognitive impairment in elderly people, confirming the importance of ergothioneine in healthy aging (Feng et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Feng et al. 2019
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
The biology of ergothioneine, an antioxidant nutraceutical
Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000301 · Cited by 296 · see citing works
“oxidative stress is known to be a damaging component of Y(8,348).”
Background
- Authors
- Feng, L., Cheah, I. K.-M., Ng, M. M.-X., Li, J., Chan, S. M., Lim, S. L., Mahendran, R., Kua, E.-H., & Halliwell, B.
- Affiliations
- National University of Singapore (SG)
- Department of Nutrition and Dietetics, Yishun Community Hospital, Singapore
- National University Hospital (SG)
- Corresponding author
- Feng, Lei
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2019-03-12
- Volume
- 68
- Issue
- 1
- Pages
- 197-203
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2914221939
- Cited by
- 112
- References
- 27
- Citations by year
- 2026: 18 · 2025: 16 · 2024: 13 · 2023: 18 · 2022: 19 · 2021: 19 · 2020: 6 · 2019: 3
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- mushroom consumption, mild cognitive impairment
- MeSH terms
- Agaricales, Aged, Aged, 80 and over, Cross-Sectional Studies, Diet, Female, Humans, Male, Middle Aged, Risk Factors, Singapore, Geriatric Assessment, Cognitive Dysfunction, Protective Factors
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