Improved discrimination of AD patients using β-amyloid (1-42) and tau levels in CSF
Open accessAbstract
Background and Aims: Epidemiology studies have shown that cardiovascular (CV) disease is primarily responsible for the mortality associated with increased pulmonary environmental particle (PM10) exposure. The mechanisms involved in PM10 mediated CV effects are unknown although changes in plasma viscosity and in the homoeostasis of blood coagulation have been implicated. It was hypothesised that PM10 exposure would result in an inflammatory response and enhance the activation of the extrinsic coagulation mechanisms in pulmonary and vascular cells in culture. Methods: Primary human monocyte derived macrophages and human umbilical cord vein endothelial, human alveolar type II epithelial (A549), and human bronchial epithelial (16HBE) cells were tested for their inflammatory and procoagulant response to PM10 exposure. IL-8, tissue factor (TF), and tissue plasminogen activator (tPA) gene expression and protein release, and coagulation enhancing ability of culture media were determined 6 and 24 hours following exposure. Results: The culture media from macrophages and 16HBE bronchial epithelial cells, but not A549 cells, exposed to PM10 had an enhanced ability to cause clotting. Furthermore, H2O2 also increased the clotting activity. Apoptosis was significantly increased in macrophages exposed to PM10 and LPS as shown by annexin V binding. TF gene expression was enhanced in macrophages exposed to PM10, and HUVEC tissue factor and tPA gene and protein expression were inhibited. Conclusions: These data indicate that PM10 has the ability to alter macrophage, epithelial, and endothelial cell function to favour blood coagulation via activation of the extrinsic pathway and inhibition of fibrinolysis pathways.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neurofibrillary tangles are made of hyperphosphorylated tau protein.
“These deposits are composed of hyperphosphorylated tau-protein (Hulstaert et al., 1999).”
From Dynamics of Gray Matter Loss in Alzheimer's Disease (2003) · cites this paper as Hulstaert et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,834 · see citing works
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856 · see citing works
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978 · see citing works
(1995) · Cited by 2,809 · see citing works
Rimm, E. B., Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Litin, L. B., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116211 · Cited by 2,104 · see citing works
Roth, M., Tym, E., Mountjoy, C. Q., Huppert, F. A., Hendrie, H., Verma, S., & Goddard, R. (1986) · British Journal of Psychiatry · doi:10.1192/bjp.149.6.698 · Cited by 2,090 · see citing works
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331 · see citing works
A simple test of visual neglect
Albert, M. L. (1973) · Neurology · doi:10.1212/wnl.23.6.658 · Cited by 1,300 · see citing works
A Measure of Primary Sociobiological Functions
Katz, S., & Akpom, C. A. (1976) · International Journal of Health Services · doi:10.2190/uurl-2ryu-wryd-ey3k · Cited by 1,232 · see citing works
Chui, H. C., Victoroff, J. I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992) · Neurology · doi:10.1212/wnl.42.3.473 · Cited by 1,201 · see citing works
Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works
Neuropsychological studies of the frontal lobes.
Stuss, D. T., & Benson, D. F. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.95.1.3 · Cited by 1,073 · see citing works
Lesion analysis in neuropsychology
Damásio, H., & Damásio, A. R. (1989) · Oxford University Press eBooks · Cited by 881 · see citing works
Mechanisms underlying hemispatial neglect
Heilman, K. M., & Valenstein, E. (1979) · Annals of Neurology · doi:10.1002/ana.410050210 · Cited by 867 · see citing works
Blennow, K., Wallin, A., Ågren, H., Spenger, C., Siegfried, J., & Vanmechelen, E. (1995) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815140 · Cited by 789 · see citing works
Self-citationLevy (1994) · doi:10.1017/s1041610294001626 · Cited by 706 · see citing works
Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”
The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association and, & National Institute on Aging Working Group (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00022-0 · Cited by 702 · see citing works
Motter, R., Vigo‐Pelfrey, C., Kholodenko, D., Barbour, R., Johnson‐Wood, K., Galasko, D., Chang, L., Miller, B., Clark, C., Green, R., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380413 · Cited by 701 · see citing works
Andreasen, N., Hesse, C., Davidsson, P., Minthon, L., Wallin, A., Winblad, B., Vanderstichele, H., Vanmechelen, E., & Blennow, K. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.673 · Cited by 660 · see citing works
Self-citationAssociation Between Nutritional Status and Cognitive Functioning in a Healthy Elderly Population
Goodwin, J. S. (1983) · JAMA · doi:10.1001/jama.1983.03330450047024 · Cited by 481 · see citing works
Galasko, D., Chang, L., Motter, R., Clark, C. M., Kaye, J., Knopman, D., Thomas, R., Kholodenko, D., Schenk, D., Lieberburg, I., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.7.937 · Cited by 442 · see citing works
Sandson, J. R., & Albert, M. L. (1984) · Neuropsychologia · doi:10.1016/0028-3932(84)90098-8 · Cited by 402 · see citing works
Dietary intake and cognitive function in a group of elderly people
Ortega, R., Requejo, A. M., Andrés, P., López-Sobaler, A. M., Quintas, M. E., Redondo, M. R., Navia, B., & Rivas, T. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.803 · Cited by 350 · see citing works
Heilman, K. M., Bowers, D., Coslett, H. B., et al. (1985) · Neurology · doi:10.1212/wnl.35.6.855 · Cited by 344 · see citing works
Kanai, M., Matsubara, E., Isoe, K., Urakami, K., Nakashima, K., Arai, H., Sasaki, H., Abe, K., Iwatsubo, T., Kosaka, T., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410440108 · Cited by 340 · see citing works
Perceptual and premotor factors of unilateral neglect
Bisiach, E., Geminiani, G. C., Berti, A., & Rusconi, M. L. (1990) · Neurology · doi:10.1212/wnl.40.8.1278 · Cited by 340 · see citing works
Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt–Jakob disease
Otto, M., Wiltfang, J., Tumani, H., Zerr, I., Lantsch, M., Kornhuber, J., Weber, T., Kretzschmar, H. A., & Poser, S. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00215-2 · Cited by 339 · see citing works
Self-citationCorrelates and Consequences of Eating Dependency in Institutionalized Elderly
Siebens, H. C., Trupe, E., Siebens, A. A., Cook, F. E., Anshen, S., Hanauer, R., & Oster, G. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb04202.x · Cited by 319 · see citing works
Hemispatial neglect affected by non‐neglected stimuli
Mark, V. W., Kooistra, C. A., & Heilman, K. M. (1988) · Neurology · doi:10.1212/wnl.38.8.1207 · Cited by 263 · see citing works
Tegnér, R., & Levander, M. (1991) · Brain · doi:10.1093/brain/114.4.1943 · Cited by 263 · see citing works
Jama, J. W., Launer, L. J., Witteman, J. C. M., den Breeijen, J. H., Breteler, M. M. B., Grobbee, D. E., & Hofman, A. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008922 · Cited by 252 · see citing works
Anterior-posterior interhemispheric differences in the loci of lesions producing visual hemineglect
Ogden, J. A. (1985) · Brain and Cognition · doi:10.1016/0278-2626(85)90054-5 · Cited by 243 · see citing works
Andreasen, N. C., Vanmechelen, E., VOORDE, A. V. D., Davidsson, P., Hesse, C., Tarvonen-Schröder, S., Räihä, I. J., Sourander, L., Winblad, B. G., & Blennow, K. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.3.298 · Cited by 227 · see citing works
Self-citationFuture directions in the development of food-frequency questionnaires
Willett, W. C. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.1.171s · Cited by 194 · see citing works
(1997) · International Journal of Epidemiology · doi:10.1093/ije/26.5.995 · Cited by 189 · see citing works
A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia
Hänninen, T., Hallikainen, M., Koivisto, K. J., Helkala, E., Reinikainen, K. J., Soininen, H. S., Mykkänen, L. M., Laakso, M., Pyörälà, K., & Riekkinen, P. J. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb05565.x · Cited by 183 · see citing works
Changes in cerebral functioning associated with normal aging
Mittenberg, W., Seidenberg, M., OʼLeary, D. S., & Digiulio, D. V. (1989) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638908400945 · Cited by 177 · see citing works
TWO KINDS OF MOTOR PERSEVERATION IN MASSIVE INJURY OF THE FRONTAL LOBES
Luria, A. R. (1965) · Brain · doi:10.1093/brain/88.1.1 · Cited by 176 · see citing works
Khatoon, S., Grundke, I., & Iqbal, K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00829-9 · Cited by 167 · see citing works
Self-citationAssessment of CSF levels of tau protein in mildly demented patients with Alzheimer's disease
Galasko, D. R., Clark, C., Chang, L., Miller, B. L., Green, R. C., Motter, R. N., & Seubert, P. A. (1997) · Neurology · doi:10.1212/wnl.48.3.632 · Cited by 153 · see citing works
Vandermeeren, M., Mercken, M., Vanmechelen, E., Six, J., Voorde, A., Martin, J.-J., & Cras, P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09823.x · Cited by 145 · see citing works
Self-citationAmyloid β protein 42(43) in cerebrospinal fluid of patients with Alzheimer's disease
Tamaoka, A., Sawamura, N., Fukushima, T., Shoji, S., Matsubara, E., Shoji, M., Hirai, S., Furiya, Y., Endoh, R., & Mori, H. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)00314-0 · Cited by 139 · see citing works
Selective Attention in Hemispatial Neglect
Rapcsak, S. Z., Verfaellie, M. H., Fleet, S., & Heilman, K. M. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520380082018 · Cited by 132 · see citing works
Diagnostic accuracy of alzheimer’s disease: A neuropathological study
Kosunen, O., Soininen, H. S., Paljärvi, L., Heinonen, O., Talasniemi, S., & Riekkinen, P. J. (1996) · Acta Neuropathologica · doi:10.1007/s004010050412 · Cited by 119 · see citing works
Visuo-spatial neglect: a new copying test to assess perceptual parsing
Marshall, J. C., & Halligan, P. W. (1993) · Journal of Neurology · doi:10.1007/bf00838444 · Cited by 110 · see citing works
Sahyoun, N. R., Otradovec, C. L., Hartz, S., et al. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.3.524 · Cited by 109 · see citing works
Intrusions and perseverations*1
Shindler, A. G. (1984) · Brain and Language · doi:10.1016/0093-934x(84)90013-0 · Cited by 101 · see citing works
Bonifacj, C., Gerber, M., Scali, J., & Daurès, J. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600387 · Cited by 101 · see citing works
Cerebrospinal protein tau is elevated in early Alzheimer's disease
Riemenschneider, M. J., Buch, K., Schmolke, M., Kurz, A., & Guder, W. G. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12810-x · Cited by 90 · see citing works
Self-citationVarieties of perseveration: A comparison of two taxonomies
Goldberg, E. (1986) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638608405191 · Cited by 90 · see citing works
A study of visual perseveration
Kinsbourne, M., & Warrington, E. K. (1963) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.26.5.468 · Cited by 87 · see citing works
Age-associated changes in the content and fatty acid composition of brain glycerophospholipids
López, G. H., de Boschero, M. G. I., Castagnet, P. I., & Giusto, N. M. (1995) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)00079-8 · Cited by 83 · see citing works
Development of a Specific Diagnostic Test for Measurement of β-Amyloid (1-42) [βA4(l-42)] in CSF
Vanderstichele, H., Blennow, K., D'Heuvaert, N., Buyse, M.-A., Wallin, A., Andreasen, N. C., Seubert, P. A., VOORDE, A. V. D., & Vanmechelen, E. (1998) · Advances in behavioral biology · doi:10.1007/978-1-4615-5337-3_110 · Cited by 70 · see citing works
Self-citationDiagnostic accuracy of Alzheimer’s disease: A clinicopathological study
Jellinger, K. A. (1996) · Acta Neuropathologica · doi:10.1007/s004010050418 · Cited by 65 · see citing works
Dissociation of Ophthalmokinetic and Melokinetic Attention in Unilateral Neglect
Bisiach, E., Tegnér, R., Làdavas, E., et al. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.5.439 · Cited by 59 · see citing works
Hypergraphia: a right hemisphere syndrome.
Yamadori, A., Mori, E., Tabuchi, M., et al. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.10.1160 · Cited by 58 · see citing works
Palinacousis: Persistent or Recurring Auditory Sensations
Jacobs, L. R., Feldman, M., DIAMOND, S. P., et al. (1973) · Cortex · doi:10.1016/s0010-9452(73)80005-x · Cited by 50 · see citing works
Verbal perseveration in aphasia
Yamadori, A. (1981) · Neuropsychologia · doi:10.1016/0028-3932(81)90026-9 · Cited by 47 · see citing works
Allison, R. S., & Hurwitz, L. J. (1967) · Brain · doi:10.1093/brain/90.2.429 · Cited by 47 · see citing works
Search patterns and neglect: A case study
Chatterjee, A., Mennemeier, M., & Heilman, K. M. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90070-3 · Cited by 46 · see citing works
Nolan, K. A., & Blass, J. P. (1992) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30495-6 · Cited by 42 · see citing works
Tau protein in Alzheimer's disease
Goedert, M., Jakes, R., Spillantini, M. G., Crowther, R. A., Cohen, P., Vanmechelen, E., Probst, A., Götz, J., & Bürki, K. (1995) · Biochemical Society Transactions · doi:10.1042/bst0230080 · Cited by 39 · see citing works
Self-citationEvaluation and Use of Diagnostic Tests in Alzheimer’s Disease
Mayeux, R. P. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00014-1 · Cited by 37 · see citing works
Biosynthesis of unsaturated fatty acids in the main cell lineages of human leukemia and lymphoma
Marzo, I., Martínez‐Lorenzo, M. J., Anel, A., Desportes, P., Álava, M. A., Naval, J., & Piñeiro, A. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00064-j · Cited by 35 · see citing works
Dras, D. D. V., & Blumenthal, H. T. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02084.x · Cited by 34 · see citing works
Heilman, K. M., & Watson, R. T. (1991) · doi:10.1093/oso/9780195062847.003.0010 · Cited by 33 · see citing works
Unilateral Hemispheric Injury and Ipsilateral Instinctive Grasp Reaction
Mori, E., & Yamadori, A. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060050087014 · Cited by 32 · see citing works
Pradignac, A., Schlienger, J.-L., Velten, M., & Méjean, L. (1995) · Aging Clinical and Experimental Research · doi:10.1007/bf03324295 · Cited by 31 · see citing works
Response‐to‐next‐patient‐stimulation
Bogousslavsky, J., & Regli, F. (1988) · Neurology · doi:10.1212/wnl.38.8.1225 · Cited by 30 · see citing works
Flagged first, then by citations
Research works printed but not linked: 31
- Van de Voorde A, Vanmechelen E, Vandermeeren M, Dessaint F, Beeckman W, Cras P. Detection of tau in cerebrospinal fluid. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM, eds. Research advances in Alzheimer's disease and related disorders. Chichester: John Wiley & Sons Ltd., 1995:189 -195.
- Vanderstichele H, Van Gool S, Brock P, et al. Monitoring of chemotherapy-induced neurotoxicity in children using CSF markers, a longitudinal study. Neurobiol Aging 1998;19:S168. Abstract.
- Hesse C, Minthon L, Wallin A, et al. Tau protein and -amyloid (1-42) in cerebrospinal fluid from Alzheimer's disease patients and controls. Neurobiol Aging 1998;19:S163. Abstract. References
- Kanheman D. Attention and effort. Englewood Cliffs, NJ: Prentice Hall, 1973.
- Brayne C, Calloway P. Normal ageing, impaired cognitive function and senile dementia of Alzheimer type: a continuum? Lancet 1988;1:1265-1267.
- Fillit HM. The clinical significance of normal cognitive decline in late life. In: Fillit HM, Butler RN. Cognitive decline. Strat- egies for prevention. Oxford: Oxford University Press, 1997: 1-7.
- Launer LJ, Masaki K, Petrovich H, Foley D, Havlik RJ. The association between midlife blood pressure levels and late-life cognitive function. JAMA 1995;274:1846 -1851.
- White LR, Foley DJ, Havlik RJ. Lifestyle risk factors for cog- nitive impairment. In: Fillit HM, Butler RN. Cognitive de- cline. Strategies for prevention. Oxford: Oxford University Press, 1997:23-32.
- Amaducci L, Baldereschi M, Di Carlo A, et al. Prevalence of chronic diseases in older Italians: comparing self-reported and clinical diagnoses. Int J Epidemiol 1997;26:995-1002.
- McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984;34:939 -944.
- World Health Organization. International statistical classifi- cation of diseases and related health problems, 10th revision (ICD-10). Chapter V, categories F00 -F99. Mental, behav- ioural, and developmental disorders, clinical description and diagnostic guidelines. Geneva: World Health Organization, 1992.
- Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189 -198.
- Barigazzi R, Della Sala S, Laiacona M, Spinnler H, Valenti V. Esplorazione testistica della memoria di prosa. Ric Psicol 1987;1:50 -80.
- Lawton MP, Brody EM. Assessment of older people: self main- taining and instrumental activities of daily living. Gerontolo- gist 1969;9:179 -186.
- Leoci CL, Centonze S, Guerra V, Cisternino AM, Misciagna G. Validazione e riproducibilita `di un questionario di frequenza alimentare semi-quantitativo autosomministrato. Giorn Ital Nutr Clin Prev 1993;1:58 -59.
- La Rue A, Koehler KM, Wayne SJ, Chiulli SJ, Haaland KY, Garry PJ. Nutritional status and cognitive functioning in a normally aging sample: a 6-year reassessment. Am J Clin Nutr 1997;65:20 -29.
- Manna C, Galletti P, Cucciolla V, Moltedo O, Leone A, Zappia V. The protective effect of the olive oil polyphenol (3,3- dihydroxyphenyl)-ethanol counteract reactive oxygen meta- bolite-indeced cytotoxicity in Caco-2 cells. J Nutr 1997;127: 286 -292.
- Kalmijn S, Feskens EJ, Launer LJ, Kromhout D. Polyunsatu- rated fatty acids, antioxidants, and cognitive functions in very old men. Am J Epidemiol 1997;145:33-41. References
- Santo Pietro MJ, Rigrodsdy S. Patterns of oral-verbal perse- verations. Brain Lang 1984;23:148 -158.
- Shindler AG, Caplan LR, Hier DB. Intrusions and persevera- tions. Brain Lang 1984;23:148 -158.
- Hudson AJ. Perseveration. Brain 1968;91:571-582.
- Helmick JW, Berg CB. Perseverations in brain injured adults. J Commun Disord 1976;9:143-156.
- Sandson J, Albert ML. Perseveration in behavioral neurology. Neurology 1987;37:1736 -1741.
- Na DL, Adair JC, Williamson DJG, Schwartz RL, Haws B, Heilman KM. Dissociation of sensory-attentional from motor- intentional neglect. J Neurol Neurosurg Psychiatry 1998;64: 331-338.
- Samuelsson H, Hjelmquist E, Naver H, Blomstrand C. Visuo- spatial neglect and an ipsilesional bias during the start of performance on conventional tests of neglect. Clinical Neuro- psychologist 1996;10:15-24.
- Posner MI, Walker JA, Friedrich FJ, Rafal RD. Effects of parietal injury on covert orienting of attention. J Neurosci 1984;4:1863-1874.
- Heilman KM, Valenstein E. Mechanisms underlying hemispa- tial neglect. Ann Neurol 1979;5:166 -170.
- Kinsbourne M. A model for the mechanism of unilateral ne- glect in space. Trans Am Neurol Assoc 1970;95:143-146.
- Kinsbourne M. Hemi-neglect and hemispheric rivalry. In: Weinstein EA, Friedland RP, eds. Hemi-inattention and hemi- sphere specialization. New York: Raven Press, 1977:41-49.
- Goldberg E, Costa L. Qualitative indices in neuropsychologi- cal assessment: executive deficit following prefrontal lesions. In: Adams K, Grant I, eds. Neuropsychological assessment of neuropsychiatric disorders. London & New York: Oxford Uni- versity Press, 1985:48 -64.
- Denny-Brown D, Chambers RA. The parietal lobe and behav- ior. Res Publ Assoc Res Nerv Ment Dis 1958;36:35-117.
Cited by
Sorted by citations
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411 · see citing works
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Self-citationKnopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey–Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001) · Neurology · doi:10.1212/wnl.56.9.1143 · Cited by 1,410 · see citing works
CSF markers for incipient Alzheimer's disease
Blennow, K., & Hampel, H. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00530-1 · Cited by 1,291 · see citing works
Self-citationDynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works
Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001 · see citing works
Georganopoulou, D. G., Chang, L., Nam, J.-M., Thaxton, C. S., Mufson, E. J., Klein, W. L., & Mirkin, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409336102 · Cited by 835 · see citing works
Visser, P. J., Verhey, F., Knol, D. L., Scheltens, P., Wahlund, L.-O., Freund-Levi, Y., Tsolaki, M., Minthon, L., Wallin, Å. K., Hampel, H., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70139-5 · Cited by 614 · see citing works
Self-citationPlasma and Cerebrospinal Fluid Levels of Amyloid β Proteins 1-40 and 1-42 in Alzheimer Disease
Mehta, P. D., Pirttilä, T., Mehta, S. P., Sersen, E. A., Aisen, P. S., & Wisniewski, H. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.1.100 · Cited by 582 · see citing works
Self-citationEvaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice
Andreasen, N., Minthon, L., Davidsson, P., Vanmechelen, E., Vanderstichele, H., Winblad, B., & Blennow, K. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.373 · Cited by 573 · see citing works
Self-citationAmnestic MCI or prodromal Alzheimer's disease?
Dubois, B., & Albert, M. L. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00710-0 · Cited by 543 · see citing works
Current state of Alzheimer’s fluid biomarkers
Molinuevo, J. L., Ayton, S., Batrla, R., Bednar, M. M., Bittner, T., Cummings, J., Fagan, A. M., Hampel, H., Mielke, M. M., Mikulskis, A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1932-x · Cited by 518 · see citing works
Self-citationDiagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People
De Meyer, G. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.179 · Cited by 462 · see citing works
Total and phosphorylated tau protein as biological markers of Alzheimer’s disease
Hampel, H., Blennow, K., Shaw, L. M., Hoessler, Y. C., Zetterberg, H., & Trojanowski, J. Q. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.010 · Cited by 389 · see citing works
Self-citationKlyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5161-07.2008 · Cited by 321 · see citing works
Self-citationStandardization of measurement of β-amyloid<sub>(1-42)</sub>in cerebrospinal fluid and plasma
Vanderstichele, H., Kerschaver, E. V., Hesse, C., Davidsson, P., Buyse, M.-A., Andreasen, N., Minthon, L., Wallin, A., Blennow, K., & Vanmechelen, E. (2000) · Amyloid · doi:10.3109/13506120009146438 · Cited by 301 · see citing works
Self-citationHampel, H., Teipel, S. J., Fuchsberger, T., Andreasen, N., Wiltfang, J., Otto, M., Shen, Y., Dodel, R., Du, Y., Farlow, M., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001473 · Cited by 287 · see citing works
Self-citationIntrathecal Chemokine Synthesis in Mild Cognitive Impairment and Alzheimer Disease
Galimberti, D., Schoonenboom, N., Scheltens, P., Fenoglio, C., Bouwman, F., Venturelli, E., Guidi, I., Blankenstein, M. A., Bresolin, N., & Scarpini, E. (2006) · Archives of Neurology · doi:10.1001/archneur.63.4.538 · Cited by 289 · see citing works
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20199356 · Cited by 286 · see citing works
Grimmer, T., Riemenschneider, M., Förstl, H., Henriksen, G., Klunk, W. E., Mathis, C. A., Shiga, T., Wester, H.-J., Kurz, A., & Drzezga, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.027 · Cited by 278 · see citing works
Self-citationMicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease
Denk, J., Boelmans, K., Siegismund, C., Lassner, D., Arlt, S., & Jahn, H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0126423 · Cited by 236 · see citing works
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202 · see citing works
Maddalena, A., Papassotiropoulos, A., Müller-Tillmanns, B., Jung, H. H., Hegi, T., Nitsch, R. M., & Hock, C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.9.1202 · Cited by 204 · see citing works
Biochemical markers in persons with preclinical familial Alzheimer disease
Ringman, J. M., Younkin, S. G., Pratico, D., Seltzer, W., Cole, G. M., Geschwind, D. H., Rodriguez-Agudelo, Y., Schaffer, B., Fein, J., Sokolow, S., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000303973.71803.81 · Cited by 198 · see citing works
van Harten, A. C., Visser, P. J., Pijnenburg, Y. A. L., Teunissen, C. E., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.08.004 · Cited by 197 · see citing works
Townley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa068 · Cited by 145 · see citing works
Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer’s disease
Welge, V., Fiege, O., Lewczuk, P., Mollenhauer, B., Esselmann, H., Klafki, H.-W., Wolf, S., Trenkwalder, C., Otto, M., Kornhuber, J., et al. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0177-6 · Cited by 152 · see citing works
Self-citationCSF biomarkers for mild cognitive impairment
Blennow, K. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01368.x · Cited by 151 · see citing works
Self-citationPreclinical AD predicts decline in memory and executive functions in subjective complaints
van Harten, A. C., Smits, L. L., Teunissen, C. E., Visser, P. J., Koene, T., Blankenstein, M. A., Scheltens, P., & van der Flier, W. M. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a8418b · Cited by 143 · see citing works
<i>APOE</i> ε4 allele is associated with reduced cerebrospinal fluid levels of Aβ42
Prince, J. A., Zetterberg, H., Andreasen, N., Marcusson, J., & Blennow, K. (2004) · Neurology · doi:10.1212/01.wnl.0000128088.08695.05 · Cited by 128 · see citing works
Self-citationGonzález‐Domínguez, R., García, A., García‐Barrera, T., Barbas, C., & Gómez‐Ariza, J. L. (2014) · ELECTROPHORESIS · doi:10.1002/elps.201400196 · Cited by 119 · see citing works
Wolfsgruber, S., Polcher, A., Koppara, A., Kleineidam, L., Frölich, L., Peters, O., Hüll, M., Rüther, E., Wiltfang, J., Maier, W., et al. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161252 · Cited by 114 · see citing works
Self-citationCilento, E. M., Jin, L., Stewart, T., Shi, M., Sheng, L., & Zhang, J. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14635 · Cited by 60 · see citing works
The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently
Shoji, M., Kanai, M., Matsubara, E., Tomidokoro, Y., Shizuka, M., Ikeda, Y., Ikeda, M., Harigaya, Y., Okamoto, K., & Hirai, S. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00229-3 · Cited by 50 · see citing works
Magnetic resonance and PET studies in the early diagnosis of Alzheimer’s disease
Mosconi, L., De Santi, S., Rusinek, H., Convit, A., & de Leon, M. J. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.5.831 · Cited by 46 · see citing works
Diagnostic biomarkers in Alzheimer’s disease
Andersen, E., Casteigne, B., Chapman, W. D., Creed, A., Foster, F., Lapins, A., Shatz, R., & Sawyer, R. P. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100041 · Cited by 42 · see citing works
Pottiez, G., Yang, L., Stewart, T., Song, N., Aro, P., Galasko, D. R., Quinn, J. F., Peskind, E. R., Shi, M., & Zhang, J. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00829 · Cited by 37 · see citing works
T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease
Haris, M., Yadav, S. K., Rizwan, A., Singh, A., Cai, K., Kaura, D., Wang, E., Davatzikos, C., Trojanowski, J. Q., Melhem, E. R., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.02.016 · Cited by 33 · see citing works
Marelli, C., Hourregue, C., Gutierrez, L.-A., Paquet, C., Menjot de Champfleur, N., De Verbizier, D., Jacob, M., Dubois, J., Maleska, A. M., Hirtz, C., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190378 · Cited by 21 · see citing works
NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression
Mengel, D., Mok, T. H., Nihat, A., Liu, W., Rissman, R. A., Galasko, D., Zetterberg, H., Mead, S., Collinge, J., & Walsh, D. M. (2021) · Cells · doi:10.3390/cells10123514 · Cited by 12 · see citing works
- Authors
- Hulstaert, F., Blennow, K., Ivanoiu, A., Schoonderwaldt, H. C., Riemenschneider, M., Deyn, P. P. D., Bancher, C., Cras, P., Wiltfang, J., Mehta, P. D., Iqbal, K., Pottel, H., Vanmechelen, E., & Vanderstichele, H.
- Affiliations
- Cliniques Universitaires Saint-Luc (BE)
- ORCID
- Venue
- Neurology
- Published
- 1999-05
- Volume
- 52
- Issue
- 8
- Pages
- 1555-1555
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2035680108
- Cited by
- 724
- References
- 75
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 22 · 2023: 11 · 2022: 14 · 2021: 26 · 2020: 20 · 2019: 13 · 2018: 17 · 2017: 24 · 2016: 23 · 2015: 27 · 2014: 38 · 2013: 33 · 2012: 33
- FWCI
- 17.74
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- other-oa
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Digital Access to Libraries (submittedVersion)
- GRO (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- European Commission
- Samsung Biomedical Research Institute
- Samsung
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Keywords
- Alzheimer's disease, amyloid-beta 42, tau protein, cerebrospinal fluid biomarkers, differential diagnosis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Humans, Middle Aged, Quality Control, Amyloid beta-Peptides, tau Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
