Cited by 203Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAntioxidant Activity and Oxidative Stress

Oxidative imbalance in patients with mild cognitive impairment and Alzheimer’s disease

GUIDI, I, GALIMBERTI, D, LONATI, S, NOVEMBRINO, C, BAMONTI, F, TIRITICCO, M, FENOGLIO, C, VENTURELLI, E +2 more·2006·Neurobiology of Aging

Abstract

Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.

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Crossref · 10.1016/j.neurobiolaging.2005.01.001

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Authors
GUIDI, I., GALIMBERTI, D., LONATI, S., NOVEMBRINO, C., BAMONTI, F., TIRITICCO, M., FENOGLIO, C., VENTURELLI, E., BARON, P., & BRESOLIN, N.
Affiliations
University of Milan (IT)
Corresponding author
GALIMBERTI, D
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2006-02
Volume
27
Issue
2
Pages
262-269
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2152628887
Cited by
203
References
37
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 13 · 2013: 11 · 2012: 16
FWCI
6.62
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
oxidative imbalance, mild cognitive impairment, Alzheimer's disease, vascular dementia, hyperhomocysteinemia, total homocysteine, reactive oxygen species, total antioxidant capacity, antioxidant enzymes, oxidative stress, disease duration
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Cocaine, Cognition Disorders, Epinephrine, Female, Homocystine, Humans, Male, Mental Status Schedule, Middle Aged, Retrospective Studies, Sex Factors, Tetracaine, Confidence Intervals, Odds Ratio, Case-Control Studies, Reactive Oxygen Species, Apolipoprotein E4

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