Alzheimer's disease: The amyloid cascade hypothesis: An update and reappraisal

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Alzheimer's disease: the amyloid cascade hypothesis

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Amyloid deposition as the central event in the aetiology of Alzheimer’s disease

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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

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The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

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Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau

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The isolation and amino acid composition of senile plaque core protein

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Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)

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Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease

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CD33 isoforms in microglia and Alzheimer's disease: Friend and foe

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Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

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Quantifying the Pathophysiological Timeline of Alzheimer's Disease

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Dual Effect of Beta-Amyloid on α7 and α4β2 Nicotinic Receptors Controlling the Release of Glutamate, Aspartate and GABA in Rat Hippocampus

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Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation

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Protein Tau: Prime Cause of Synaptic and Neuronal Degeneration in Alzheimer's Disease

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In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of Alzheimer’s Disease Mouse Model

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Serotonin 6 receptor controls alzheimer’s disease and depression

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Quick Assembly of 1,4-Diphenyltriazoles as Probes Targeting β-Amyloid Aggregates in Alzheimer's Disease

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Alzheimer’s Disease Biomarkers and Epigenetic Intermediates Following Exposure to Pb In Vitro

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Cell-to-Cell Transmission of α-Synuclein Aggregates

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Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

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APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress

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Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease

Kashyap, P., Kalaiselvan, V., Kumar, R. S., & Kumar, S. (2020) · Molecules · doi:10.3390/molecules25071609 · Cited by 59

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

Ameen‐Ali, K. E., Wharton, S. B., Simpson, J. E., Heath, P. R., Sharp, P. S., & Berwick, J. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12440 · Cited by 59

Classification of Alzheimer’s and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET

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Amyloid-β, Tau, and Dementia

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Synaptic vesicle cycle and amyloid β: Biting the hand that feeds

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Vascular and Metabolic Factors in Alzheimer’s Disease and Related Dementias: Introduction

Iadecola, C. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0319-y · Cited by 59

The Anti-Amyloid Monoclonal Antibody Lecanemab: 16 Cautionary Notes

Kepp, K. P., Sensi, S. L., Johnsen, K. B., Barrio, J. R., Høilund‐Carlsen, P. F., Neve, R. L., Alavi, A. A., Herrup, K., Perry, G. L., Robakis, N. K. R. K., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230099 · Cited by 56

Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity

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Multi-Target-Directed Ligands as an Effective Strategy for the Treatment of Alzheimer’s Disease

Kumar, R., Kumar, V., Kumar, B., Thakur, A., & Dwivedi, A. R. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210512005508 · Cited by 55

Reaching the Limits of Genome-wide Significance in Alzheimer Disease

Pedersen, N. L. (2010) · JAMA · doi:10.1001/jama.2010.609 · Cited by 54

Neurogenetic disorders across the lifespan: from aberrant development to degeneration

Hickman, R. A., O’Shea, S. A., Mehler, M. F., & Chung, W. K. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00595-5 · Cited by 59

Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review

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Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain

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Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease

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Introducing Human APOE into A β Transgenic Mouse Models

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Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways

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Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation

Arumugam, N., Almansour, A. I., Kumar, R. S., Kotresha, D., Saiswaroop, R., & Sivaramakrishnan, V. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.03.058 · Cited by 52

Targeting Mitochondrial Bioenergetics for Alzheimers Prevention and Treatment

Yao, J., & Brinton, R. D. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072517 · Cited by 50

Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers

Banerjee, S., Hashemi, M., Zagorski, K., & Lyubchenko, Y. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031129 · Cited by 51

Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Argyreia speciosa Roots by In Vitro and In Silico Study

Kashyap, P., Ram, H., Shukla, S. D., & Kumar, S. (2020) · Neuroscience Insights · doi:10.1177/2633105520937693 · Cited by 49

In 2024, the amyloid-cascade-hypothesis still remains a working hypothesis, no less but certainly no more

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BEYOND AMYLOID: The Next Generation of Alzheimer's Disease Therapeutics

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Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

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Dementia spectrum disorders: lessons learnt from decades with PET research

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Multi-scale graph-based grading for Alzheimer’s disease prediction

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Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors

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Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral

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An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study

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Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives

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Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease

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Neprilysin Protects against Cerebral Amyloid Angiopathy and Aβ‐Induced Degeneration of Cerebrovascular Smooth Muscle Cells

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Explorative and targeted neuroproteomics in Alzheimer's disease

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Down syndrome, beta-amyloid and neuroimaging

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siRNA Therapeutics: Future Promise for Neurodegenerative Diseases

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Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum

Jia, D., Rao, C., Xue, S., & Lei, J. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.12.032 · Cited by 44

Salivary Biomarkers: Future Approaches for Early Diagnosis of Neurodegenerative Diseases

Schepici, G., Silvestro, S., Trubiani, O., Bramanti, P., & Mazzon, E. (2020) · Brain Sciences · doi:10.3390/brainsci10040245 · Cited by 44

ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice

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Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors

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The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

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Aβ 42 /Aβ 40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease

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Oxidative stress increases levels of endogenous amyloid‐β peptides secreted from primary chick brain neurons

Goldsbury, C. S., Whiteman, I. T., Jeong, E. V., & Lim, Y. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00423.x · Cited by 44

Diffuse Amyloid- β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons’ Brains Lacking Neuritic Amyloid Plaques

Abner, E. L., Neltner, J. H., Jicha, G. A., Patel, E., Anderson, S., Wilcock, D. M., Eldik, L. J. V., & Nelson, P. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180514 · Cited by 42

The α-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease

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A Structure-Toxicity Study of Aß42 Reveals a New Anti-Parallel Aggregation Pathway

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Prevention approaches in a preclinical canine model of Alzheimer’s disease: benefits and challenges

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Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain

Chen, K.-H., & Cui, M. (2017) · MedChemComm · doi:10.1039/c7md00064b · Cited by 42

Temperature and toxic Tau in Alzheimer's disease: new insights

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Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis

Granic, A., & Potter, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060718 · Cited by 40

The Role of Apolipoprotein E Isoforms in Alzheimer’s Disease

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Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice

Li, Z., Bi, H. C., Jiang, H., Song, J., Meng, Q., Zhang, Y., & Fei, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11747 · Cited by 40

Recent imaging advances in neurology

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Autophagy impairment by caspase‐1‐dependent inflammation mediates memory loss in response to β‐Amyloid peptide accumulation

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Nanoparticle Delivery of Transition-Metal Chelators to the Brain: Oxidative Stress will Never See it Coming!

Bonda, D., Liu, G., Men, P., Perry, G. L., Smith, M. A., & Zhu, X. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712799960709 · Cited by 39

Anti-amyloid-beta to tau-based immunization: developments in immunotherapy for Alzheimer's disease

Lambracht‐Washington, D., & Rosenberg, R. N. (2013) · ImmunoTargets and Therapy · doi:10.2147/itt.s31428 · Cited by 39

Structure–Property Relationships of Polyethylene Glycol Modified Fluorophore as Near-Infrared Aβ Imaging Probes

Zhou, K., Li, Y., Peng, Y., Cui, X., Dai, J., & Cui, M. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01712 · Cited by 39

Oxidative Stress Induces Apolipoprotein D Overexpression in Hippocampus during Aging and Alzheimer's Disease

Martínez‐Pinilla, E., Navarro, A., Ordóñez, C., del Valle, E., & Tolivia, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130215 · Cited by 40

Role of HMG-CoA Reductase Inhibitors in Neurological Disorders

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Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives

Basiri, A., Murugaiyah, V., Osman, H., Kumar, R. S., Kia, Y., & Ali, M. A. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.058 · Cited by 37

Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration

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Animal Models for Alzheimer’s Disease and Frontotemporal Dementia: A Perspective

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Selenomethionine reduces the deposition of beta-amyloid plaques by modulating β-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease

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Mouse models of oxidative phosphorylation defects: Powerful tools to study the pathobiology of mitochondrial diseases

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Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

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Connectome-wide network analysis of white matter connectivity in Alzheimer's disease

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MicroRNAs as newer therapeutic targets: A big hope from a tiny player

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The molecular pathology of Alzheimer’s disease

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Access to 2-(Het)aryl and 2-Styryl Benzoxazoles via Palladium-Catalyzed Aminocarbonylation of Aryl and Vinyl Bromides

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Biophysical, Biochemical, and Behavioral Implications of ApoE3 Conjugated Donepezil Nanomedicine in a Aβ 1–42 Induced Alzheimer’s Disease Rat Model

Krishna, K. V., Saha, R. N., & Dubey, S. K. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00430 · Cited by 35

A History of Senile Plaques: From Alzheimer to Amyloid Imaging

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Correspondence to Author:

Behera, S. K., Behera, R. K., Barik, M. R., & Lokhande, R. S. (2013)

doi:10.1155/2012/369808 Review Article Alzheimer’s Disease and the Amyloid Cascade Hypothesis: A Critical Review

Reitz, C. (2012)

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