Cited by 162Epigenetics and DNA MethylationHeavy Metal Exposure and ToxicityAlzheimer's disease research and treatments

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer’s disease

Bihaqi, Syed Waseem, Huang, Hui, Wu, Jinfang, Zawia, Nasser H.·2011·Journal of Alzheimer’s Disease

DOI 10.3233/jad-2011-111013

Open this paper in CoChat — free account

Abstract

The beginnings of late onset Alzheimer's disease (LOAD) are still unknown; however, the progressive and latent nature of neurodegeneration suggests that the triggering event occurs earlier in life. Aging primates exposed to lead (Pb) as infants exhibited an overexpression of the amyloid-β protein precursor (AβPP), amyloid-β (Aβ) and enhanced pathologic neurodegeneration. In this study, we measured the latent expression of a wide array of brain-specific genes and explored whether epigenetic pathways mediated such latent molecular and pathological changes. We analyzed the levels of proteins associated with DNA methylation, i.e., DNA methyltransferase 1 (Dnmt1), DNA methyltransferase3a (Dnmt3a), methyl-CpG binding protein-2 (MeCP2) and those involved in histone modifications (acetylated and methylated histones). We monitored the expression profiles of these intermediates across the lifespan and analyzed their levels in 23-year-old primate brains exposed to Pb as infants. Developmental Pb exposure altered the gene expression of the arrayed genes, which were predominately repressed, with fewer upregulated genes. The latent induction and repression of genes was accompanied by a significant decrease in the protein levels of Dnmts, MeCP2, and proteins involved in histone modifications. The attenuation of DNA methylation enzymes is consistent with hypomethylating effects, which promote upregulation of the genes, while the alterations in the histone modifiers are associated with the repression of genes. Hence, we deduce that early life exposure to Pb can reprogram gene expression resulting in both upregulation and down-regulation of genes through alternate epigenetic pathways contributing to an enhancement in neurodegeneration in old age.

Integrity signals

Registry

Crossref · 10.3233/jad-2011-111013

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,791
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1119 · Cited by 2,168
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,153
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
Nan, X., Campoy, F. J., & Bird, A. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,288

Show all 60 references

Sorted by citations

Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680
Bioinorganic Chemistry of Alzheimer’s Disease
Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
Chouliaras, L., Mastroeni, D., Delvaux, E., Grover, A., Kenis, G., Hof, P. R., Steinbusch, H. W. M., Coleman, P. D., Rutten, B. P. F., & van den Hove, D. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.021 · Cited by 442
Clinical and molecular aspects of lead toxicity: An update
Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1408562 · Cited by 402
Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias
Bakulski, K. M., Seo, Y. A., Hickman, R. C., Brandt, D. J., Vadari, H. S., Hu, H., & Park, S. K. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200282 · Cited by 361
Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence
Ruiz-Hernandez, A., Kuo, C.-C., Rentero-Garrido, P., Tang, W., Redón, J., Ordovás, J. M., Navas‐Acién, A., & Téllez-Plaza, M. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0055-7 · Cited by 215
Epigenetic targets of some toxicologically relevant metals: a review of the literature
Cheng, T., Choudhuri, S., & Muldoon‐Jacobs, K. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2717 · Cited by 194
Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges
Ray, P. D., Yosim, A. E., & Fry, R. C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00201 · Cited by 181
DNA methylation, a hand behind neurodegenerative diseases
Lu, H., Liu, X., Yu-Lin, D. E. N. G., & Qing, H. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00085 · Cited by 181
DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167
Epigenetics of early-life lead exposure and effects on brain development
Senut, M.-C., Cingolani, P., Sen, A., Kruger, A., Shaik, A., Hirsch, H., Suhr, S. T., & Ruden, D. (2012) · Epigenomics · doi:10.2217/epi.12.58 · Cited by 151
Lead Exposure Disrupts Global DNA Methylation in Human Embryonic Stem Cells and Alters Their Neuronal Differentiation
Senut, M.-C., Sen, A., Cingolani, P., Shaik, A., Land, S. J., & Ruden, D. M. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu028 · Cited by 135
Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants
Grova, N., Schroeder, H., Olivier, J. L., & Turner, J. D. (2019) · International Journal of Genomics · doi:10.1155/2019/2085496 · Cited by 138
Consequences of lead exposure, and it’s emerging role as an epigenetic modifier in the aging brain
Eid, A., & Zawia, N. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.04.006 · Cited by 121
Self-citation
Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus
Schneider, J. S., Kidd, S. K., & Anderson, D. W. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2012.12.004 · Cited by 115
Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease
Adwan, L. I., & Zawia, N. H. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.03.010 · Cited by 118
Self-citation
Zebrafish as a model for investigating developmental lead (Pb) neurotoxicity as a risk factor in adult neurodegenerative disease: A mini-review
Lee, J., & Freeman, J. L. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.03.008 · Cited by 114
Epigenetic epidemiology: Promises for public health research
Bakulski, K. M., & Fallin, M. D. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21850 · Cited by 113
Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease
Kabir, M. T., Uddin, M. S., Zaman, S., Begum, Y., Ashraf, G. M., Bin-Jumah, M. N., BUNGAU, S. G., Mousa, S. A., & Abdel‐Daim, M. M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02096-w · Cited by 113
Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)
Bihaqi, S. W., & Zawia, N. H. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.07.010 · Cited by 110
Self-citation
Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb2+: Implications for an Environmental Basis of Neurodevelopmental Disorders
Stansfield, K. H., Pilsner, J. R., Lu, Q., Wright, R. O., & Guilarte, T. R. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs090 · Cited by 108
Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms
Yu, G., Wu, L., Su, Q., Ji, X., Zhou, J., Wu, S., Tang, Y. C., & Li, H. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123563 · Cited by 104
Epigenetic Basis of Lead-Induced Neurological Disorders
Wang, T., Zhang, J., & Xu, Y. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134878 · Cited by 99
Infantile exposure to lead and late‐age cognitive decline: Relevance to AD
Bihaqi, S. W., Bahmani, A., Subaiea, G. M., & Zawia, N. H. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.012 · Cited by 97
Self-citation
Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease
Eid, A., Bihaqi, S. W., Renehan, W. E., & Zawia, N. H. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.02.002 · Cited by 94
Self-citation
Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
Suresh, S., Ankul Singh, S., Rushendran, R., Vellapandian, C., & Prajapati, B. G. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1303111 · Cited by 93
Activity-dependent synaptic plasticity modulates the critical phase of brain development
Chaudhury, S., Sharma, V., Kumar, V., Nag, T. C., & Wadhwa, S. (2015) · Brain and Development · doi:10.1016/j.braindev.2015.10.008 · Cited by 100
Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation
Ryu, H.-W., Lee, D. H., Won, H.-R., Kim, K. H., Seong, Y. J., & Kwon, S. H. (2015) · Toxicological Research · doi:10.5487/tr.2015.31.1.001 · Cited by 94
Lead (Pb) exposure reduces global DNA methylation level by non-competitive inhibition and alteration of dnmt expression
Sánchez, O. F., Lee, J.-Y., Hing, N. Y. K., Kim, S.-E., Freeman, J. L., & Yuan, C. (2016) · Metallomics · doi:10.1039/c6mt00198j · Cited by 90
Amyloid β: one of three danger‐associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease
Clark, I. A., & Vissel, B. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13181 · Cited by 84
Dynamics of DNA Methylation in Aging and Alzheimer's Disease
Irier, H. A., & Jin, P. (2012) · DNA and Cell Biology · doi:10.1089/dna.2011.1565 · Cited by 85
A developmental perspective on early-life exposure to neurotoxicants
Bellinger, D. C., Matthews-Bellinger, J. A., & Kordas, K. (2016) · Environment International · doi:10.1016/j.envint.2016.05.014 · Cited by 83
Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight, and Insulin Response across the Murine Life-Course
Faulk, C. D., Barks, A. K., Sánchez, B. N., Zhang, Z., Anderson, O. S., Peterson, K. E., & Dolinoy, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104273 · Cited by 77
Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: Relevance to AD
Bihaqi, S. W., Bahmani, A., Adem, A., & Zawia, N. H. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.06.008 · Cited by 76
Self-citation
Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer’s Disease
Masoud, A. M., Bihaqi, S. W., Machan, J. T., Zawia, N. H., & Renehan, W. E. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151018 · Cited by 73
Self-citation
Heavy Metals and Epigenetic Alterations in Brain Tumors
Caffo, M., Caruso, G., Fata, G. L., Barresi, V., Visalli, M., Venza, M., & Venza, I. (2015) · Current Genomics · doi:10.2174/138920291506150106151847 · Cited by 74
Long-term probiotic intervention mitigates memory dysfunction through a novel H3K27me3-based mechanism in lead-exposed rats
Xiao, J., Wang, T., Xu, Y., Gu, X., Li, D., Niu, K., Wang, T., Zhao, J., Zhou, R., & Wang, H.-L. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0719-8 · Cited by 70
Environmental Exposure to Lead (Pb) and Variations in Its Susceptibility
Kim, J.-A., Lee, Y., & Yang, M. (2014) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2014.907461 · Cited by 67
Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ‐secretase by downregulating DNA methyltransferase 3b
Liu, H., Qiu, H., Yang, J., Ni, J., & Le, W. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.05.019 · Cited by 66
Local Melatonin Regulates Inflammation Resolution: A Common Factor in Neurodegenerative, Psychiatric and Systemic Inflammatory Disorders
Anderson, G., & Maes, M. H. J. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140711091400 · Cited by 65
Early life exposure to lead (Pb) and changes in DNA methylation: relevance to Alzheimer’s disease
Bihaqi, S. W. (2019) · Reviews on Environmental Health · doi:10.1515/reveh-2018-0076 · Cited by 64
Self-citation
Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation
Sun, H., Wang, N., Nie, X., Zhao, L., Li, Q., Cang, Z., Chen, C., Lu, M., Cheng, J., Zhai, H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169958 · Cited by 57
Pathogenic Mechanisms of Heavy Metal Induced-Alzheimer’s Disease
Lee, H. J., Park, M. K., & Seo, Y. R. (2018) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-018-0340-x · Cited by 57
Developmental exposure to Pb2+ induces transgenerational changes to zebrafish brain transcriptome
Meyer, D. N., Crofts, E. J., Akemann, C., Gurdziel, K., Farr, R. L., Baker, B. B., Weber, D. N., & Baker, T. R. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125527 · Cited by 56
Ecogenetics of lead toxicity and its influence on risk assessment
Mani, M. S., Kabekkodu, S. P., Joshi, M. B., & Dsouza, H. S. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119851253 · Cited by 55
Epigenetic modifications associated with pathophysiological effects of lead exposure
Khalid, M., & Abdollahi, M. R. (2019) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2019.1640581 · Cited by 54
The Chemical Exposome of Human Aging
Misra, B. B. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.574936 · Cited by 58
Environmental Toxicants—Induced Epigenetic Alterations and Their Reversers
Kim, M.-J., BAE, M., Na, H.-K., & Yang, M. (2012) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2012.731959 · Cited by 50
Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer’s disease
Meleleo, D., Notarachille, G., Mangini, V., & Arnesano, F. (2019) · European Biophysics Journal · doi:10.1007/s00249-018-1344-9 · Cited by 47
Perinatal Lead (Pb) Exposure and Cortical Neuron-Specific DNA Methylation in Male Mice
Dou, J., Farooqui, Z., Faulk, C. D., Barks, A. K., Jones, T. R., Dolinoy, D. C., & Bakulski, K. M. (2019) · Genes · doi:10.3390/genes10040274 · Cited by 49
One-carbon epigenetics and redox biology of neurodegeneration
Coppedè, F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.002 · Cited by 48
Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers
Adwan, L. I., Subaiea, G. M., & Zawia, N. H. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.009 · Cited by 45
Self-citation
Longitudinal epigenetic drift in mice perinatally exposed to lead
Faulk, C. D., Liu, K., Barks, A. K., Goodrich, J. M., & Dolinoy, D. C. (2014) · Epigenetics · doi:10.4161/epi.29024 · Cited by 48
Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead
Sánchez-Martín, F. J., Lindquist, D. M., Landero-Figueroa, J., Zhang, X., Chen, J., Cecil, K. M., Medvedovic, M., & Puga, A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.004 · Cited by 43
Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment
Gu, X., Xu, Y., Xue, W., Wu, Y., Ye, Z., Xiao, G., & Wang, H.-L. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1912-7 · Cited by 43
Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α‐synuclein, amyloid‐β and insulin resistance in neurodegenerative diseases
Clark, I. A., & Vissel, B. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14471 · Cited by 42
Early-Life Environment Influence on Late-Onset Alzheimer’s Disease
Gauvrit, T., Benderradji, H., Buée, L., Blum, D. L., & Vieau, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.834661 · Cited by 46
Environmental Alterations of Epigenetics Prior to the Birth
Lo, C., & Zhou, F. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00001-9 · Cited by 44
Alterations in gene expression due to chronic lead exposure induce behavioral changes
Hernández-Coro, A., Sánchez-Hernández, B. E., Montes, S., Martínez‐Lazcano, J. C., González‐Guevara, E., & Pérez‐Severiano, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.031 · Cited by 42
Lead Induces Similar Gene Expression Changes in Brains of Gestationally Exposed Adult Mice and in Neurons Differentiated from Mouse Embryonic Stem Cells
Sánchez-Martín, F. J., Fan, Y., Lindquist, D. M., Xia, Y., & Puga, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080558 · Cited by 41
DNA methyltransferase 3, a target of microRNA-29c, contributes to neuronal proliferation by regulating the expression of brain-derived neurotrophic factor
Yang, G., Song, Y., Zhou, X., Deng, Y., Liu, T., Weng, G., Yu, D., & Pan, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3531 · Cited by 39
Developmental reelin expression and time point-specific alterations from lead exposure in zebrafish
Peterson, S. M., Zhang, J., & Freeman, J. L. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.04.007 · Cited by 40
Toxicogenomics and Cancer Susceptibility: Advances with Next-Generation Sequencing
Ning, B., Su, Z., Mei, N., Hong, H., Deng, H., Shi, L. M., Fuscoe, J. C., & Tolleson, W. H. (2014) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2014.907460 · Cited by 37
Environmental Deflection: The Impact of Toxicant Exposures on the Aging Epigenome
Kochmanski, J. J., Montrose, L. B., Goodrich, J. M., & Dolinoy, D. C. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx005 · Cited by 38
Lead‐induced neurodevelopmental lesion and epigenetic landscape: Implication in neurological disorders
Liu, M., Liu, R., Wang, R., Ba, Y., Yu, F., Deng, Q., & Huang, H. (2022) · Journal of Applied Toxicology · doi:10.1002/jat.4419 · Cited by 34
Self-citation
Embryonic exposure to 10 μg L−1lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain
Lee, J., & Freeman, J. L. (2016) · Metallomics · doi:10.1039/c5mt00267b · Cited by 34
The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships
Nguyen, H. D., & Kim, M. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03343-y · Cited by 34
Exposure to Metals, Pesticides, and Air Pollutants: Focus on Resulting DNA Methylation Changes in Neurodegenerative Diseases
Stoccoro, A., & Coppedè, F. (2024) · Biomolecules · doi:10.3390/biom14111366 · Cited by 33
Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans
Rudgalvyte, M., Peltonen, J., Lakso, M., & Wong, G. (2016) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2016.10.001 · Cited by 30
Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
Anderson, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223757 · Cited by 31
Childhood Lead Exposure and Adult Outcomes
Bellinger, D. C. (2017) · JAMA · doi:10.1001/jama.2017.1560 · Cited by 30
Broader Insights into Understanding Tumor Necrosis Factor and Neurodegenerative Disease Pathogenesis Infer New Therapeutic Approaches
Clark, I., & Vissel, B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201186 · Cited by 27
DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium
Bian, X., & Gao, Y. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12691-6 · Cited by 27
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?
Coppedè, F. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1916469 · Cited by 30
Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances
Mallick, R., & Duttaroy, A. K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105627 · Cited by 27
Mass Spectrometry for Investigating the Effects of Toxic Metals on Nucleic Acid Modifications
Xiong, J., Yuan, B., & Feng, Y. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00042 · Cited by 26
Role of C/EBPα hypermethylation in diesel engine exhaust exposure-induced lung inflammation
Wang, N., Li, Q., Liu, H., Li, L., Han, W., & Hao, W. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109500 · Cited by 26
Low-level lead exposure impairs fronto-executive functions: A call to update the DSM–5 with lead poisoning as a neurodevelopmental disorder.
Neuwirth, L. S., Lopez, O. E., Schneider, J. S., & Markowitz, M. E. (2020) · Psychology & Neuroscience · doi:10.1037/pne0000225 · Cited by 28
Association between blood lead level and subsequent Alzheimer’s disease mortality
Horton, C. J., Weng, H., & Wells, E. M. (2019) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000045 · Cited by 25
An epigenome‐wide DNA methylation study of workers with an occupational exposure to lead
Zhang, X., He, Z., Feng, B., & Shao, H. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3816 · Cited by 25
Trimester-Specific Associations of Prenatal Lead Exposure With Infant Cord Blood DNA Methylation at Birth
Rygiel, C. A., Dolinoy, D. C., Perng, W., Jones, T. R., Solano, M., Hu, H., Téllez‐Rojo, M. M., Peterson, K. E., & Goodrich, J. M. (2020) · Epigenetics Insights · doi:10.1177/2516865720938669 · Cited by 25
Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease
Clark, I. A., & Vissel, B. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.030 · Cited by 23
The Roles of Histone Modifications in Metal-Induced Neurological Disorders
Wu, Y., Wang, R., Liu, R., Ba, Y., & Huang, H. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03134-5 · Cited by 23
Self-citation
Lead exposure and tau hyperphosphorylation: An in vitro study
Bihaqi, S. W., Eid, A., & Zawia, N. H. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.07.029 · Cited by 23
Self-citation
Altered microRNA, mRNA, and Protein Expression of Neurodegeneration-Related Biomarkers and Their Transcriptional and Epigenetic Modifiers in a Human Tau Transgenic Mouse Model in Response to Developmental Lead Exposure
Masoud, A. M., Bihaqi, S. W., Alansi, B. H., Dash, M. E., Subaiea, G. M., Renehan, W. E., & Zawia, N. H. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170824 · Cited by 23
Self-citation
Reproductive toxicity induced by lead exposure: Effects on gametogenesis and sex steroid signaling in teleost fish
Ferreira, C. S., Ribeiro, Y. M., Moreira, D. P., Paschoalini, A. L., Bazzoli, N., & Rizzo, E. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139896 · Cited by 21
Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects
Iram, F., Shahid, M., Ansari, J., Ashraf, G. M., Hassan, M. I., & Islam, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102342 · Cited by 20
Upregulation of zinc transporter 2 in the blood–CSF barrier following lead exposure
Fu, X., Zeng, A., Zheng, W., & Du, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213509213 · Cited by 20
Mitochondria-Mediated Moderation of Apoptosis by EGCG in Cytotoxic Neuronal Cells Induced by Lead (Pb) and Amyloid Peptides
Ayyalasomayajula, N., Bandaru, L. J. M., Chetty, C. S., Dixit, P. K., & Challa, S. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02959-w · Cited by 19
Epimutational effects of electronic cigarettes
Yan, R., Chen, X.-L., Xu, Y., & Lau, A. T. Y. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12985-9 · Cited by 21
Hair Mineral and Trace Element Content in Children with Down’s Syndrome
Grabeklis, A. R., Skalny, A. V., Skalnaya, A. A., Zhegalova, I. V., Notova, S. V., Mazaletskaya, A. L., Геннадиевна, С. М., & Tinkov, A. A. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1506-8 · Cited by 18
Histone Acetylation Maps in Aged Mice Developmentally Exposed to Lead: Epigenetic Drift and Alzheimer-Related Genes
Eid, A., Bihaqi, S. W., Hemme, C. L., Gaspar, J. M., Hart, R. P., & Zawia, N. H. (2018) · Epigenomics · doi:10.2217/epi-2017-0143 · Cited by 18
Self-citation
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Stoccoro, A. (2025) · Biology · doi:10.3390/biology14010098 · Cited by 18
Advances in the Genetics and Epigenetics of Neurodegenerative Diseases
Coppedè, F. (2013) · Epigenetics of Degenerative Diseases · doi:10.2478/end-2012-0002 · Cited by 17
MicroRNA-106b-5p participates in lead (Pb2+)-induced cell viability inhibition by targeting XIAP in HT-22 and PC12 cells
Xue, C., Kang, B., Su, P., Wang, D., Zhao, F., Zhang, J., Wang, X., Lang, H., & Cao, Z. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104876 · Cited by 17
Early-life Pb exposure as a potential risk factor for Alzheimer’s disease: are there hazards for the Mexican population?
Chin-Chan, M., Cobos-Puc, L. E., Alvarado-Cruz, I., Bayar, M., & Ermolaeva, M. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01739-1 · Cited by 16
Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications
Wang, Y., Hu, Y., Wu, Z., Su, Y., Ba, Y., Zhang, H., Li, X., Cheng, X., Li, W., & Huang, H. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.12.015 · Cited by 15
Self-citation
Matters of life and death: the role of chromatin remodeling proteins in retinal neuron survival
Lagali, P. S., & Picketts, D. J. (2011) · Journal of ocular biology, diseases, and informatics · doi:10.1007/s12177-012-9080-3 · Cited by 15
The Role of P62 /Nrf2/Keap1 Signaling Pathway in Lead‐Induced Neurological Dysfunction
Peng, D., Wei, P., Li, Z., Wei, R., Li, H., & Li, S. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70566 · Cited by 14
Heavy metals in the cell nucleus - role in pathogenesis
Sas‐Nowosielska, H., & Pawlas, N. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2014_834 · Cited by 14

Authors: Bihaqi, S. W., Huang, H., Wu, J., & Zawia, N. H.
Affiliations: University of Rhode Island (US)
Zhengzhou University (CN)
ORCID: Bihaqi, Syed Waseem
Huang, Hui
Wu, Jinfang
Venue: Journal of Alzheimer’s Disease
Publisher: SAGE Publications
Published: 2011-12-12
Volume: 27
Issue: 4
Pages: 819-833
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2011-111013
OpenAlex: W1693568153
Cited by: 162
References: 60
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 12 · 2014: 19 · 2013: 14 · 2012: 10
FWCI: 5.72
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
Institute of Environmental Science and Research
National Institute of Environmental Research
National Institutes of Health
National Institute of Environmental Health Sciences (R01ES015867)
National Center for Research Resources (P20RR016457)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: lead exposure
MeSH terms: Age Factors, Aging, Animals, Animals, Newborn, Disease Models, Animal, Female, Humans, Lead, Lead Poisoning, Macaca fascicularis, Nerve Tissue Proteins, RNA, Messenger, Transcription Factors, DNA Modification Methylases, Cohort Studies, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, DNA Methylation, rab5 GTP-Binding Proteins, Epigenesis, Genetic, Methyl-CpG-Binding Protein 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer’s disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks