Olfactory bulb integrity in frontotemporal dementia and Alzheimer’s disease
Abstract
Background: Olfactory dysfunction is highly prevalent in dementia syndromes, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The structural integrity of the olfactory bulb (OB) is thought to play a critical role in odor detection and identification, but no MRI study has measured OB volume in FTD, or measured OB volume longitudinally in AD. Objective: To measure OB volume in FTD and AD patients longitudinally using MRI. Methods: This study measured OB volumes using MRI in patients diagnosed with behavioral-variant FTD ( n = 55), semantic dementia ( n = 34), progressive non-fluent aphasia ( n = 30), AD ( n = 50), and healthy age-matched controls ( n = 55) at their first visit to a dementia research clinic (‘baseline’). Imaging data in patients 12-months later were analyzed where available ( n = 84) for longitudinal assessment. Volumes of subcortical and cortical olfactory regions (‘olfactory network’) were obtained via surface-based morphometry. Results: Results revealed that in AD and FTD at baseline, OB volumes were similar to controls, whereas volumes of olfactory network regions were significantly reduced in all patient groups except in progressive non-fluent aphasia. Longitudinal data revealed that OB volume became significantly reduced (10–25% volume reduction) in all dementia groups with disease progression. Conclusion: Olfactory dysfunction is common in patients diagnosed with AD or FTD, but our results indicate that there is no detectable volume loss to the OBs upon first presentation to the clinic. Our findings indicate that the OBs become detectably atrophied later in the disease process. OB atrophy indicates the potential usefulness for OBs to be targeted in interventions to improve olfactory function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Olfactory bulb atrophy, specific to more severe disease stages, and olfactory dysfunction have been correlated over 1 year in bvFTD.
“olfactory bulb atrophy (specific to more severe disease stages) and olfactory dysfunction (loss of smell) over 1 year (Carnemolla et al., 2022)”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Carnemolla et al., 2022
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · cited 1× · see citing works
“The spread of tau pathology throughout the brain in Alzheimer’s disease, in an outwards direction from more medial structures [71–73] resulting in more severe neuronal loss in the olfactory tract compared to the OB, supports this view [74].”
Lovibond, P. F., & Lovibond, S. H. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)00075-u · Cited by 14,523 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Self-citationClassification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1610 · Cited by 2,016 · see citing works
Hsieh, S., Schubert, S., Hoon, C., Mioshi, E., & Hodges, J. R. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000351671 · Cited by 970 · see citing works
Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
Chan, D., Fox, N. C., Scahill, R. I., Crum, W. R., Whitwell, J. L., Leschziner, G., Rossor, A. M., Stevens, J. M., Cipolotti, L., & Rossor, M. N. (2001) · Annals of Neurology · doi:10.1002/ana.92 · Cited by 749 · see citing works
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders
Jucker, M., & Walker, L. C. (2011) · Annals of Neurology · doi:10.1002/ana.22615 · Cited by 622 · see citing works
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
Galton, C. J., Patterson, K., Graham, K., Lambon-Ralph, M. A., Williams, G., Antoun, N., Sahakian, B. J., & Hodges, J. R. (2001) · Neurology · doi:10.1212/wnl.57.2.216 · Cited by 582 · see citing works
Khan, U. A., Liu, L., Provenzano, F. A., Berman, D. E., Profaci, C. P., Sloan, R., Mayeux, R., Duff, K. E., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3606 · Cited by 561 · see citing works
Prevalence of Olfactory Dysfunction: The Skövde Population‐Based Study
Bramerson, A., Johansson, L., Ek, L., Nordin, S., & Bende, M. (2004) · The Laryngoscope · doi:10.1097/00005537-200404000-00026 · Cited by 560 · see citing works
Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes
Coyle-Gilchrist, I. T. S., Dick, K. M., Patterson, K. E., Rodríguez, P. V., Wehmann, E., Wilcox, A., Lansdall, C. J., Dawson, K., Wiggins, J., Mead, S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002638 · Cited by 546 · see citing works
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Seeley, W. W., Crawford, R., Rascovsky, K., Kramer, J. H., Weiner, M., Miller, B. L., & Gorno-Tempini, M. L. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.38 · Cited by 506 · see citing works
Ikeda, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.4.371 · Cited by 499 · see citing works
Ng, F., Trauer, T., Dodd, S., Callaly, T., Campbell, S., & Berk, M. (2007) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2007.00217.x · Cited by 406 · see citing works
Clinical staging and disease progression in frontotemporal dementia
Mioshi, E., Hsieh, S., Savage, S., Hornberger, M., & Hodges, J. R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e04070 · Cited by 362 · see citing works
Olfactory bulb involvement in neurodegenerative diseases
Attems, J., Walker, L., & Jellinger, K. A. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1261-7 · Cited by 341 · see citing works
Correlation between olfactory bulb volume and olfactory function
Buschhüter, D., Smitka, M., Puschmann, S., Gerber, J. C., Witt, M., Abolmaali, N., & Hummel, T. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.004 · Cited by 329 · see citing works
Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula
Nestor, P. J. (2003) · Brain · doi:10.1093/brain/awg240 · Cited by 324 · see citing works
The association between smoking and smell and taste impairment in the general population
Vennemann, M., Hummel, T., & Berger, K. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0807-9 · Cited by 305 · see citing works
The Prevalence and Incidence of Frontotemporal Dementia: a Systematic Review
Hogan, D. B., Jetté, N., Fiest, K. M., Roberts, J. I., Pearson, D. M., Smith, E. E., Roach, P., Kirk, A., Pringsheim, T. M., & Maxwell, C. J. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.25 · Cited by 286 · see citing works
Understanding the role of the primary somatosensory cortex: Opportunities for rehabilitation
Borich, M., Brodie, S. M., Gray, W. A., Ionta, S., & Boyd, L. A. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.07.007 · Cited by 274 · see citing works
Bond, T. G., & Fox, C. M. (2013) · Psychology Press eBooks · doi:10.4324/9781410614575 · Cited by 270 · see citing works
Rabinovici, G. D., Seeley, W. W., Kim, E. J., Gorno‐Tempini, M. L., Rascovsky, K., Pagliaro, T. A., Allison, S. C., Halabi, C., Kramer, J. H., Johnson, J. K., et al. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507308779 · Cited by 256 · see citing works
Nordin, S., Monsch, A. U., & Murphy, C. A. (1995) · The Journals of Gerontology Series B · doi:10.1093/geronb/50b.4.p187 · Cited by 250 · see citing works
Luzzi, S., Snowden, J. S., Neary, D., Coccia, M., Provinciali, L., & Ralph, M. A. L. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.12.008 · Cited by 239 · see citing works
The Cambridge Behavioural Inventory revised
Wear, H. J., Wedderburn, C. J., Mioshi, E., Williams-Gray, C. H., Mason, S. L., Barker, R. A., & Hodges, J. R. (2008) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642009dn20200005 · Cited by 225 · see citing works
On the right side? A longitudinal study of left- versus right-lateralized semantic dementia
Kumfor, F., Landin-Romero, R., Devenney, E., Hutchings, R., Grasso, R., Hodges, J. R., & Piguet, O. (2016) · Brain · doi:10.1093/brain/awv387 · Cited by 224 · see citing works
Self-citationMullol, J., Alobid, I., Mariño‐Sánchez, F., Quintó, L., de Haro, J., Bernal‐Sprekelsen, M. S., Valero, A., Picado, C., & Marı́n, C. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001256 · Cited by 218 · see citing works
Effects of olfactory training: a meta-analysis
Sorokowska, A., Drechsler, E., Karwowski, M., & Hummel, T. R. (2017) · Rhinology Journal · doi:10.4193/rhino16.195 · Cited by 198 · see citing works
Progressive Nonfluent Aphasia and Its Characteristic Motor Speech Deficits
Ogar, J., Dronkers, N., Brambati, S., Miller, B., & Gorno-Tempini, M. (2007) · Alzheimer Disease and Associated Disorders · doi:10.1097/wad.0b013e31815d19fe · Cited by 173 · see citing works
Mundiñano, I.-C., Caballero, M. C., Ordóñez, C., Hernández, M., DiCaudo, C., Marcilla, I., Erro, M. E., Tuñon, M.-T., & Luquín, M. R. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0830-2 · Cited by 171 · see citing works
Kovács, T., Cairns, & Lantos (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00208.x · Cited by 162 · see citing works
A clinical-radiological framework of the right temporal variant of frontotemporal dementia
Ulugut Erkoyun, H., Groot, C., Heilbron, R., Nelissen, A., van Rossum, J., Jutten, R., Koene, T., van der Flier, W. M., Wattjes, M. P., Scheltens, P., et al. (2020) · Brain · doi:10.1093/brain/awaa225 · Cited by 161 · see citing works
Bhatnagar, K. P., Kennedy, R. C., Baron, G., & Greenberg, R. A. (1987) · The Anatomical Record · doi:10.1002/ar.1092180112 · Cited by 159 · see citing works
Olfactory Training in Patients with Parkinson's Disease
Haehner, A., Tosch, C., Wolz, M., Klingelhoefer, L., Fauser, M., Storch, A., Reichmann, H., & Hummel, T. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061680 · Cited by 159 · see citing works
Reduced olfactory bulb and tract volume in early Alzheimer's disease—A MRI study
Thomann, P. A., Santos, V. D., Toro, P., Schönknecht, P., Essig, M., & Schröder, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.001 · Cited by 142 · see citing works
Meisami, E., MIKHAIL, L., BAIM, D., & Bhatnagar, K. P. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10649.x · Cited by 137 · see citing works
Pathology of the Insular Cortex in Alzheimer Disease Depends on Cortical Architecture
Bonthius, D. J., Solodkin, A., & Hoesen, G. W. V. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000182983.87106.d1 · Cited by 128 · see citing works
Duff, K., McCaffrey, R. J., & Solomon, G. S. (2002) · Journal of Neuropsychiatry · doi:10.1176/jnp.14.2.197 · Cited by 121 · see citing works
So, M., Foxe, D., Kumfor, F., Murray, C., Hsieh, S., Savage, G. R., Ahmed, R. M., Burrell, J. R., Hodges, J. R., Irish, M., et al. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617718000541 · Cited by 121 · see citing works
Self-citationChanges in olfactory bulb volume following lateralized olfactory training
Negoias, S., Pietsch, K., & Hummel, T. R. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9567-9 · Cited by 115 · see citing works
Thomann, P. A., Santos, V. D., Seidl, U., Toro, P., Essig, M., & Schröder, J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1036 · Cited by 104 · see citing works
Flavour processing in semantic dementia
Piwnica-Worms, K. E., Omar, R., Hailstone, J., & Warren, J. (2010) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/j.cortex.2009.07.002 · Cited by 89 · see citing works
Croy, I., Bojanowski, V., & Hummel, T. R. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.11.008 · Cited by 87 · see citing works
Olfactory Function in Corticobasal Syndrome and Frontotemporal Dementia
Pardini, M., Huey, E. D., Cavanagh, A. L., & Grafman, J. H. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.521 · Cited by 85 · see citing works
Primary progressive aphasia: A dementia of the language network
Mesulam, M. M. (2013) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642013dn70100002 · Cited by 84 · see citing works
Yang, Y. M., & Schmitt, H. P. (2001) · Acta Neuropathologica · doi:10.1007/s004010000293 · Cited by 81 · see citing works
Evaluating the clinical usefulness of structured questions in parosmia assessment
Landis, B. N., Frasnelli, J., Croy, I., & Hummel, T. R. (2010) · The Laryngoscope · doi:10.1002/lary.20955 · Cited by 81 · see citing works
Chemosensory dysfunction in neurodegenerative diseases
(2019) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63855-7.00020-4 · Cited by 78 · see citing works
Maternal status regulates cortical responses to the body odor of newborns
Lundström, J. N., Mathe, A., Schaal, B., Frasnelli, J., Nitzsche, K. I., Gerber, J. C., & Hummel, T. R. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00597 · Cited by 74 · see citing works
Olfactory processing in bipolar disorder, major depression, and anxiety
Kamath, V. J., Paksarian, D., Cui, L., Moberg, P. J., Turetsky, B. I., & Merikangas, K. R. (2018) · Bipolar Disorders · doi:10.1111/bdi.12625 · Cited by 69 · see citing works
Hsieh, J. W., Keller, A., Wong, M., Jiang, R., & Vosshall, L. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711415114 · Cited by 66 · see citing works
Human Olfaction without Apparent Olfactory Bulbs
Weiss, T., Soroka, T., Gorodisky, L., Shushan, S., Snitz, K., Weissgross, R., Furman‐Haran, E., Dhollander, T., & Sobel, N. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.006 · Cited by 66 · see citing works
Bahar‐Fuchs, A., Moss, S. A., Rowe, C. C., & Savage, G. R. (2011) · International Psychogeriatrics · doi:10.1017/s1041610210002371 · Cited by 63 · see citing works
Olfactory Identification in Elderly Schizophrenia and Alzheimer’s Disease
Moberg, P. J., Doty, R. L., Mahr, R. N., Mesholam, R. I., Arnold, S. E., Turetsky, B. I., & Gur, R. E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00015-8 · Cited by 63 · see citing works
Odor identification deficits in frontotemporal dementia: A preliminary study
McLaughlin, N. C. R., & Westervelt, H. J. (2007) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2007.07.008 · Cited by 57 · see citing works
Hagemeier, J., Woodward, M. R., Rafique, U. A., Amrutkar, C. V., Bergsland, N., Dwyer, M. G., Benedict, R. H. B., Zivadinov, R., & Szigeti, K. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.08.003 · Cited by 55 · see citing works
Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia
Shaw, S. R., El-Omar, H., Roquet, D., Hodges, J. R., Piguet, O., Ahmed, R. M., Whitton, A. E., & Irish, M. (2021) · Brain · doi:10.1093/brain/awab032 · Cited by 55 · see citing works
Self-citationPhantom Smells: Prevalence and Correlates in a Population-Based Sample of Older Adults
Sjölund, S., Larsson, M. U., Olofsson, J., Seubert, J., & Laukka, E. J. (2017) · Chemical Senses · doi:10.1093/chemse/bjx006 · Cited by 52 · see citing works
Frontotemporal Dementia Syndromes
Hodges, J. R. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9781316135457 · Cited by 50 · see citing works
Complex neural representation of odour information in the olfactory bulb
Li, A., Rao, X., Zhou, Y., & Restrepo, D. (2019) · Acta Physiologica · doi:10.1111/apha.13333 · Cited by 49 · see citing works
Reduced olfactory bulb volume in depression—A structural moderator analysis
Rottstädt, F., Han, P., Weidner, K., Schellong, J., Wolff‐Stephan, S., Strauß, T., Kitzler, H. H., Hummel, T. R., & Croy, I. (2018) · Human Brain Mapping · doi:10.1002/hbm.24024 · Cited by 48 · see citing works
Chen, B., Zhong, X., Mai, N., Peng, Q., Wu, Z., Ouyang, C., Zhang, W., Liang, W., Wu, Y., Liu, S., et al. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy016 · Cited by 46 · see citing works
Frontotemporal dementias: main syndromes and underlying brain changes
Piguet, O., & Kumfor, F. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000792 · Cited by 46 · see citing works
Self-citationFlavour identification in frontotemporal lobar degeneration
Omar, R., Mahoney, C., Buckley, A. H., & Warren, J. D. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-303853 · Cited by 45 · see citing works
Yaldizli, Ö., Penner, I., Yonekawa, T., Naegelin, Y., Kühle, J., Pardini, M., Chard, D., Stippich, C., Kira, J., Bendfeldt, K., et al. (2015) · European Journal of Neurology · doi:10.1111/ene.12891 · Cited by 44 · see citing works
Jobin, B., Boller, B., & Frasnelli, J. (2021) · Brain Sciences · doi:10.3390/brainsci11081010 · Cited by 41 · see citing works
Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status
Poessel, M., Breuer, N., Joshi, A., Pampel, A., Villringer, A., Hummel, T. R., & Horstmann, A. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.586998 · Cited by 40 · see citing works
Loss of awareness of hyposmia is associated with mild cognitive impairment in Parkinson's disease
Kawasaki, I., Baba, T., Takeda, A., & Mori, E. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.11.015 · Cited by 39 · see citing works
Odour identification in frontotemporal lobar degeneration
Rami, L., Loy, C. T., Hailstone, J. C., & Warren, J. D. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0379-5 · Cited by 36 · see citing works
Odor Perception and Neuropathology in Neurodegenerative Diseases and Schizophrenia
Doty, R. L., Hawkes, C. H., Good, K. P., & Duda, J. E. (2015) · doi:10.1002/9781118971758.ch18 · Cited by 31 · see citing works
Diagnosing, monitoring and managing behavioural variant frontotemporal dementia
Piguet, O., Kumfor, F., & Hodges, J. R. (2017) · The Medical Journal of Australia · doi:10.5694/mja16.01458 · Cited by 28 · see citing works
Self-citationPre-aging of the Olfactory Bulb in Major Depression With High Comorbidity of Mental Disorders
Rottstaedt, F., Weidner, K., Hummel, T. R., & Croy, I. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00354 · Cited by 26 · see citing works
Parosmia and Neurological Disorders: A Neglected Association
Ciurleo, R., Salvo, S. D., Bonanno, L., Marino, S., Bramanti, P., & Caminiti, F. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.543275 · Cited by 22 · see citing works
Clinical presentations of frontotemporal dementia
Kipps, C., Knibb, J. A., & Hodges, J. R. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9781316135457.004 · Cited by 19 · see citing works
Olfactory bulb involvement in Pick's disease
Yoshimura, N. (1988) · Acta Neuropathologica · doi:10.1007/bf00687432 · Cited by 17 · see citing works
Can we Smell without an Olfactory Bulb?
Rombaux, P., Mouraux, A., Bertrand, B., Duprez, T. P. J., & Hummel, T. R. (2007) · American Journal of Rhinology · doi:10.2500/ajr.2007.21.3067 · Cited by 17 · see citing works
Olfactory impairment in posterior cortical atrophy
Witoonpanich, P., Cash, D. M., Shakespeare, T. J., Yong, K. X. X., Nicholas, J. M., Omar, R., Crutch, S. J., Rossor, M. N., & Warren, J. D. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304497 · Cited by 14 · see citing works
Multimodal cuing of autobiographical memory in semantic dementia.
Greenberg, D. L., Ogar, J. M., Viskontas, I. V., Tempini, M. L. G., Miller, B. L., & Knowlton, B. J. (2010) · Neuropsychology · doi:10.1037/a0021005 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Olfactory Impairment and Frailty
Yeo, B. S. Y., Chan, J. H., Tan, B. K. J., Liu, X., Tay, L., Teo, N. W. Y., & Charn, T. C. (2024) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2024.1854 · Cited by 26 · see citing works
Ulugut, H., Younes, K., Montembeault, M., Bertoux, M., Irish, M., Kumfor, F., Fumagalli, G., Samancı, B., Illán‐Gala, I., Thompson, J. C., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01252-4 · Cited by 15 · see citing works
“Clinical studies based on retrospective analyses of medical records frequently identify this de fi cit 4,32,39,51,55,56 .”
Self-citationFieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
“…(cross-sectional) (Macfarlane et al., 2015), posterior parietal atrophy and loss of recent autobiographical memory over one year (Irish et al., 2018), and olfactory bulb atrophy (specific to more severe disease stages) and olfactory dysfunction (loss of smell) over 1 year (Carnemolla et al., 2022).”
BackgroundAnglada‐Huguet, M., Endepols, H., Sydow, A., Hilgers, R., Neumaier, B., Drzezga, A. E., Kaniyappan, S., Mandelkow�, E., & Mandelkow, E.-M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119260 · Cited by 7 · see citing works
“Indeed, the olfactory dysfunction is among the earliest features of AD and FTD [51,52], and the accumulation of aggregated tau protein in this brain structure correlates with the progression and the severity of the disease in other brain regions [53], underscoring the potential utility of olfactory tissue in the early…”
BackgroundSmell loss is associated with cognitive impairment in amyotrophic lateral sclerosis patients
Huang, X., Wu, J., Zhang, N., Teng, J., Yang, Q., Zhang, Y., Yin, T., Zhou, W., Fan, D., & Ye, S. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14851 · Cited by 6 · see citing works
Xu, M. Q., Liu, J., Liu, Q., Gong, Y., Li, Y., Zhang, J., Shi, S., & Shi, Y. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1326394 · Cited by 5 · see citing works
Ulugut, H., Younes, K., Montembeault, M., Bertoux, M., Irish, M., Kumfor, F., Fumagalli, G., Samancı, B., Illán‐Gala, I., Thompson, J. C., et al. (2024) · medRxiv · doi:10.1101/2024.10.18.24315786 · Cited by 5 · see citing works
Self-citationOlfactory Network Disruptions as Mediators of Cognitive Impairment in De Novo Parkinson's Disease
Xing, Y., Zhou, H., Chen, S., Wang, Y., Ren, J., Cao, Y., Li, J., & Liu, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70198 · Cited by 4 · see citing works
“Carnemolla et al. found that in patients with AD and fron-totemporal dementia [19], the volumes of olfactory network regions significantly reduced.”
Multifactorial Causation of Alzheimer’s Disease Due to COVID-19
Monllor, P., Kumar, P., Lloret, M.-Á., Ftara, A., Leon, J.-L., Lopez, B., Cervera‐Ferri, A., & Lloret, A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230396 · Cited by 4 · see citing works
Preliminary Findings on the Morphometric Characteristics of the Olfactory Bulb in the Cat
Alvites, R., CAINE, A. R., Cherubini, G. B., Varejão, A. S. P., & Maurício, A. C. (2024) · Animals · doi:10.3390/ani14243590 · Cited by 2 · see citing works
“…other evidence in animals and humans indicating that cellular activity in the OB and the capacity for long-time memory of odors is greater in adults than in juvenile animals [38], although OB volume tends to decrease in older adults [40], particularly in cases of neurodegenerative evolution [24].”
Asghar, A., Narayan, R. K., Kumar, R., Sarangi, P. K., Patra, A., Kumar, A., & Zabihullah, M. (2025) · Indian journal of radiology and imaging - new series/Indian journal of radiology and imaging/Indian Journal of Radiology & Imaging · doi:10.1055/s-0045-1811932 · Cited by 1 · see citing works
Zecca, V., Palombelli, G., Vanacore, N., & Canese, R. (2026) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.70296 · Cited by 2 · see citing works
Wu, J., Liu, Y.-J., He, J., Shi, Y.-Q., & Zhao, B.-X. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1759500
“Olfactory and cognitive deficits in AD are closely related to lesions of the olfactory bulb and hippocampus (Attems et al., 2014; Carnemolla et al., 2022; Salimi et al., 2022).”
Görgülü, F. F., & Görgülü, O. (2026) · Medicina · doi:10.3390/medicina62081615
“Some have found no significant difference in OB volume between patients with AD or MCI and controls, particularly in the earliest stages, and have suggested that detectable OB atrophy may emerge only later in the disease course [11,22].”
Chmiel, J., & Kładna, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188043
- Authors
- Carnemolla, S. E., Kumfor, F., Liang, C. T., Foxe, D., Ahmed, R. M., & Piguet, O.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Piguet, Olivier
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2022-07-11
- Volume
- 89
- Issue
- 1
- Pages
- 51-66
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W4285095414
- Cited by
- 16
- References
- 81
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- olfactory bulb, olfactory dysfunction
- MeSH terms
- Alzheimer Disease, Olfaction Disorders, Aphasia, Atrophy, Humans, Magnetic Resonance Imaging, Olfactory Bulb, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
