Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
Abstract
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease. Three groups of 10 subjects were studied: semantic dementia patients, Alzheimer's disease patients, and control subjects. The temporal lobe structures measured were the amygdala, hippocampus, entorhinal cortex, parahippocampal gyrus, fusiform gyrus, and superior, middle, and inferior temporal gyri. Semantic dementia and Alzheimer's disease groups did not differ significantly on global atrophy measures. In semantic dementia, there was asymmetrical temporal lobe atrophy, with greater left-sided damage. There was an anteroposterior gradient in the distribution of temporal lobe atrophy, with more marked atrophy anteriorly. All left anterior temporal lobe structures were affected in semantic dementia, with the entorhinal cortex, amygdala, middle and inferior temporal gyri, and fusiform gyrus the most severely damaged. Asymmetrical, predominantly anterior hippocampal atrophy was also present. In Alzheimer's disease, there was symmetrical atrophy of the entorhinal cortex, hippocampus, and amygdala, with no evidence of an anteroposterior gradient in the distribution of temporal lobe or hippocampal atrophy. These data demonstrate that there is a marked difference in the distribution of temporal lobe atrophy in semantic dementia and Alzheimer's disease. In addition, the pattern of atrophy in semantic dementia suggests that semantic memory is subserved by anterior temporal lobe structures, within which the middle and inferior temporal gyri may play a key role.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Semantic dementia is typified by progressive degeneration of the anterior temporal lobes, most severe on the ventral surface, including the anterior temporal fusiform gyrus, temporal pole, anterior hippocampus and amygdala.
“From a neural standpoint, semantic dementia is typified by the progressive degeneration of the anterior temporal lobes (Hodges and Patterson, 2007), which is most severe on the ventral surface, including the anterior temporal fusiform gyrus, temporal pole, anterior hippocampus and amygdala (Chan et al., 2001;Galton et al., 2001;Davies et al., 2004;Whitwell et al., 2005;Mion et al., 2010).”
From Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia (2012) · cites this paper as Chan et al., 2001
Hippocampal atrophy occurs in various neurological and psychiatric conditions, notably semantic dementia.
“Indeed, hippocampal atrophy has been highlighted in various neurological and psychiatric conditions (Geuze et al., 2005), and notably in other neurodegenerative disorders such as semantic dementia (SD) (Chan et al., 2001; Davies et al., 2004; Desgranges et al., 2007; Galton et al., 2001; Nestor et al., 2006).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Chan et al., 2001
Hippocampal atrophy differed between SD and AD patients in terms of hemispheric and anterior-posterior asymmetry.
“Contrastingly, hippocampal atrophy differed between SD and AD patients in terms of hemispheric and anterior–posterior asymmetry, in agreement with previous reports”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Chan et al., 2001
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282 · see citing works
SEMANTIC DEMENTIA: PROGRESSIVE FLUENT APHASIA WITH TEMPORAL LOBE ATROPHY
HODGES, J. R., PATTERSON, K., OXBURY, S., & FUNNELL, E. (1992) · Brain · doi:10.1093/brain/115.6.1783 · Cited by 1,710 · see citing works
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665 · see citing works
The Selective Impairment of Semantic Memory
Warrington, E. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400525 · Cited by 1,509 · see citing works
Semantic dementia: A form of circumscribed cerebral atrophy
Snowden, J. S., Goulding, P., & Neary, D. (1989) · Behavioural Neurology · doi:10.1155/1989/124043 · Cited by 944 · see citing works
MR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease
Jack, C. R., Petersen, R. C., O’Brien, P. C., & Tangalos, E. G. (1992) · Neurology · doi:10.1212/wnl.42.1.183 · Cited by 878 · see citing works
Semantic dementia: a form of circumscribed cerebral atrophy
Snowden, J. (1995) · Neurocase · doi:10.1093/neucas/1.1.39-y · Cited by 868 · see citing works
Response Latencies in Naming Objects
Oldfield, R. C., & Wingfield, A. (1965) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470216508416445 · Cited by 811 · see citing works
MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
Insausti, R., Juottonen, K., Soininen, H. S., Insausti, A. M., Partanen, K. P. L., Vainio, P. A., Laakso, M. P., & Pitkänen, A. (1998) · PubMed Central · Cited by 774 · see citing works
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
Killiany, R., Gómez‐Isla, T., Moss, M. B., Kikinis, R., Sándor, T., Jolesz, F. A., Tanzi, R. E., Jones, K. J., Hyman, B. T., & Albert, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4 · Cited by 659 · see citing works
Presymptomatic hippocampal atrophy in Alzheimer's disease: A longitudinal MRI study
Fox, N. C., Warrington, E. K., Freeborough, P. A., Hartikainen, P., Kennedy, A. M., Stevens, J. M., & Rossor, M. N. (1996) · Brain · doi:10.1093/brain/119.6.2001 · Cited by 656 · see citing works
Self-citationThe role of the right hippocampus in the recall of spatial location
Smith, M. L., & Milner, B. A. (1981) · Neuropsychologia · doi:10.1016/0028-3932(81)90090-7 · Cited by 648 · see citing works
Amygdala core nuclei volumes are decreased in recurrent major depression
Sheline, Y. I., Gado, M. H., & Price, J. L. (1998) · NeuroReport · doi:10.1097/00001756-199806220-00021 · Cited by 472 · see citing works
Smirni, D., Turriziani, P., Oliveri, M., Smirni, P., & Lisa Cipolotti, A. (2010) · PsycTESTS Dataset · doi:10.1037/t76621-000 · Cited by 470 · see citing works
Kesslak, J. P., Nalcioğlu, O., & Cotman, C. W. (1991) · Neurology · doi:10.1212/wnl.41.1.51 · Cited by 434 · see citing works
DISTURBED PERCEPTION OF COLOURS ASSOCIATED WITH LOCALIZED CEREBRAL LESIONS
Meadows, J. C. (1974) · Brain · doi:10.1093/brain/97.1.615 · Cited by 405 · see citing works
Disrupted temporal lobe connections in semantic dementia
Mummery, C. J., Patterson, K. E., Wise, R. J. S., Vandenbergh, R., Price, C. J., & Hodges, J. R. (1999) · Brain · doi:10.1093/brain/122.1.61 · Cited by 387 · see citing works
Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease
Killiany, R., Moss, M. B., Albert, M., Sándor, T., Tieman, J., & Jolesz, F. A. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540090052010 · Cited by 371 · see citing works
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease
Seab, J. P., Jagust, W. J., Wong, S. T. S., Roos, M. S., Reed, B. R., & Budinger, T. F. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910080210 · Cited by 364 · see citing works
Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD
de Leon, M. J., Bobinski, M., Convit, A. J., Wolf, O. T., & Insausti, R. (2001) · Neurology · doi:10.1212/wnl.56.6.820 · Cited by 351 · see citing works
Myocardial Disorders in the Elderly
Brown, J. J., DAVIES, D. L., Lever, A., PARKER, R. A., & ROBERTSON, J. I. (1963) · The Lancet · doi:10.1016/s0140-6736(63)90462-8 · Cited by 348 · see citing works
Deterioration of word meaning: Implications for reading
Patterson, K. E., & Hodges, J. R. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90096-5 · Cited by 341 · see citing works
Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD
Xu, Y., Jack, C. R., O’Brien, P. C., Kokmen, E., Smith, G. E., Ivnik, R. J., Boeve, B. F., Tangalos, R. G., & Petersen, R. C. (2000) · Neurology · doi:10.1212/wnl.54.9.1760 · Cited by 335 · see citing works
Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease.
Lehéricy, S., Baulac, M., Jacques Chiras, C., Pierot, L., Martin-Duverneuil, N., Pillon, B., Deweer, B., Dubois, B., & Marsault, C. (1994) · PubMed Central · Cited by 308 · see citing works
Nonfluent progressive aphasia and semantic dementia: A comparative neuropsychological study
Hodges, J. R., & Patterson, K. E. (1996) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700001685 · Cited by 301 · see citing works
EARLY MARKER FOR ALZHEIMER'S DISEASE: THE ATROPHIC HIPPOCAMPUS
De Leon, M., George, A., Stylopoulos, L., Smith, G., & Miller, D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90911-2 · Cited by 284 · see citing works
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease
Frisoni, G. B., Laakso, M. P., Beltramello, A., Geroldi, C., Bianchetti, A., Soininen, H. S., & Trabucchi, M. (1999) · Neurology · doi:10.1212/wnl.52.1.91 · Cited by 284 · see citing works
Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans
Freeborough, P. A., Fox, N. C., & Kitney, R. I. (1997) · Computer Methods and Programs in Biomedicine · doi:10.1016/s0169-2607(97)01803-8 · Cited by 276 · see citing works
Self-citationVolumes of the Entorhinal and Perirhinal Cortices in Alzheimer’s Disease
Juottonen, K., Laakso, M. P., Insausti, R., Lehtovirta, M., Pitkänen, A., Partanen, K. P. L., & Soininen, H. S. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00007-4 · Cited by 262 · see citing works
Soininen, H. S., Partanen, K. P. L., Pitkänen, A., Vainio, P. A., Hänninen, T., Hallikainen, M., Koivisto, K. J., & Riekkinen, P. J. (1994) · Neurology · doi:10.1212/wnl.44.9.1660 · Cited by 259 · see citing works
The role of the left hippocampal region in the acquisition and retention of story content
Frisk, V. A., & Milner, B. A. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90061-r · Cited by 259 · see citing works
The Impact of Semantic Memory Loss on Phonological Representations
Patterson, K. E., Graham, N. L., & Hodges, J. R. (1994) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1994.6.1.57 · Cited by 234 · see citing works
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease.
Juottonen, K., Laakso, M. P., Partanen, K. P. L., & Soininen, H. S. (1999) · PubMed · Cited by 212 · see citing works
Insights from semantic dementia on the relationship between episodic and semantic memory
Graham, K. S., Simons, J. S., Pratt, K. H., Patterson, K. E., & Hodges, J. R. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(99)00073-1 · Cited by 198 · see citing works
Semantic memory and reading abilities: A case report
Cipolotti, L., & Warrington, E. K. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700000163 · Cited by 164 · see citing works
Self-citationHETEROGENEITY IN PROGRESSIVE APHASIA DUE TO FOCAL CORTICAL ATROPHY
Tyrrell, P. J., Warrington, E. K., Frackowiak, R. S. J., et al. (1990) · Brain · doi:10.1093/brain/113.5.1321 · Cited by 164 · see citing works
Intracranial Volume and Alzheimer Disease
Jenkins, R., Fox, N. C., Rossor, A. M., Harvey, R. J., & Rossor, M. N. (2000) · Archives of Neurology · doi:10.1001/archneur.57.2.220 · Cited by 127 · see citing works
Self-citationMeasuring dysgraphia: a graded-difficulty spelling test.
Baxter, D. M., & Warrington, E. K. (1994) · PubMed · doi:10.3233/ben-1994-73-401 · Cited by 87 · see citing works
Measuring Dysgraphia: A Graded-Difficulty Spelling Test
Baxter, D. M., & Warrington, E. K. (1994) · Behavioural Neurology · doi:10.1155/1994/659593 · Cited by 86 · see citing works
Living/non-living dissociation in a case of semantic dementia: A SPECT activation study
Cardebat, D., Démonet, J., Celsis, P., et al. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00040-1 · Cited by 53 · see citing works
Meningeal cells can communicate with astrocytes by calcium signaling
Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works
Fronto-temporal lobar degeneration
Mackenzie, R. (1997) · Journal of Clinical Neuroscience · doi:10.1016/s0967-5868(97)90116-8 · Cited by 36 · see citing works
Payoff: A Neglected Factor in Reaction Time Measurement
Annett, J. (1966) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640746608400041 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Where do you know what you know? The representation of semantic knowledge in the human brain
Patterson, K., Nestor, P. J., & Rogers, T. T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2277 · Cited by 2,706 · see citing works
The human hippocampus and spatial and episodic memory
Burgess, N., Maguire, E. A., & O'Keefe, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00830-9 · Cited by 2,401 · see citing works
Development and neurophysiology of mentalizing
Frith, U., & Frith, C. D. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1218 · Cited by 2,306 · see citing works
Functional imaging of ‘theory of mind’
Gallagher, H. L., & Frith, C. D. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)00025-6 · Cited by 2,092 · see citing works
Brain Imaging in Alzheimer Disease
Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006213 · Cited by 875 · see citing works
Self-citationPatterns of brain atrophy in frontotemporal dementia and semantic dementia
Rosen, H. J., Gorno–Tempini, M. L., Goldman, W. P., Perry, R. J., Schuff, N., Weiner, M., Feiwell, R., Kramer, J. H., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.58.2.198 · Cited by 841 · see citing works
Clinical, genetic and pathological heterogeneity of frontotemporal dementia: A review
Seelaar, H., Rohrer, J. D., Pijnenburg, Y. A. L., Fox, N. C., & van Swieten, J. C. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.212225 · Cited by 609 · see citing works
Self-citationIkeda, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.4.371 · Cited by 499 · see citing works
Considering the role of semantic memory in episodic future thinking: evidence from semantic dementia
Irish, M., Addis, D. R., Hodges, J. R., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws119 · Cited by 405 · see citing works
The clinical profile of right temporal lobe atrophy
Chan, D., Anderson, V., Pijnenburg, Y., Whitwell, J., Barnes, J., Scahill, R., Stevens, J. M., Barkhof, F., Scheltens, P., Rossor, M. N., et al. (2009) · Brain · doi:10.1093/brain/awp037 · Cited by 377 · see citing works
Self-citationDistinguishing Alzheimer’s disease from other major forms of dementia
Karantzoulis, S., & Galvin, J. E. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.155 · Cited by 385 · see citing works
Declarative memory impairments in Alzheimer's disease and semantic dementia
Nestor, P. J., Fryer, T. D., & Hodges, J. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.008 · Cited by 370 · see citing works
The Pivotal Role of Semantic Memory in Remembering the Past and Imagining the Future
Irish, M., & Piguet, O. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00027 · Cited by 345 · see citing works
Speech production: Wernicke, Broca and beyond
Blank, S. C. (2002) · Brain · doi:10.1093/brain/awf191 · Cited by 342 · see citing works
The pathological basis of semantic dementia
Davies, R. R., Hodges, J. R., Kril, J. J., Patterson, K., Halliday, G. M., & Xuereb, J. H. (2005) · Brain · doi:10.1093/brain/awh582 · Cited by 325 · see citing works
Converging language streams in the human temporal lobe
Spitsyna, G., Warren, J. E., Scott, S. K., Turkheimer, F. E., & Wise, R. J. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0559-06.2006 · Cited by 312 · see citing works
Interdependence of episodic and semantic memory: evidence from neuropsychology
GREENBERG, D. L., & VERFAELLIE, M. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617710000676 · Cited by 320 · see citing works
Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study
Binder, J. R., Gross, W. L., Allendorfer, J. B., Bonilha, L., Chapin, J., Edwards, J. C., Grabowski, T. J., Langfitt, J. T., Loring, D. W., Lowe, M. J., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.048 · Cited by 300 · see citing works
Grueso, S., & Viejo-Sobera, R. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00900-w · Cited by 303 · see citing works
Pruessner, J. C. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.12.1342 · Cited by 297 · see citing works
La Joie, R., Perrotin, A., de La Sayette, V., Egret, S., Doeuvre, L., Belliard, S., Eustache, F., Desgranges, B., & Chételat, G. (2013) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.08.007 · Cited by 290 · see citing works
Defining a left-lateralized response specific to intelligible speech using fMRI
Narain, C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg083 · Cited by 246 · see citing works
The human perirhinal cortex and semantic memory
Davies, R. R., Graham, K. S., Xuereb, J. H., Williams, G. B., & Hodges, J. R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03710.x · Cited by 238 · see citing works
Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer’s disease
Grossman, M., Farmer, J., Leight, S., Work, M., Moore, P., Van Deerlin, V., Pratico, D., Clark, C. M., Coslett, H. B., Chatterjee, A., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20477 · Cited by 228 · see citing works
Irish, M., Hornberger, M., Lah, S., Miller, L., Pengas, G., Nestor, P. J., Hodges, J. R., & Piguet, O. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.05.017 · Cited by 223 · see citing works
Episodic memory in frontotemporal dementia: a critical review
Hornberger, M., & Piguet, O. (2012) · Brain · doi:10.1093/brain/aws011 · Cited by 210 · see citing works
Kipps, C. M., Davies, R. R., Mitchell, J., Kril, J. J., Halliday, G. M., & Hodges, J. R. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000100973 · Cited by 172 · see citing works
Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration
Gorno-Tempini, M. L., Rankin, K. P., Woolley, J. D., Rosen, H. J., Phengrasamy, L., & Miller, B. L. (2004) · Cortex · doi:10.1016/s0010-9452(08)70159-x · Cited by 164 · see citing works
Semantic dementia and the left and right temporal lobes
Snowden, J. S., Harris, J. M., Thompson, J. C., Kobylecki, C., Jones, M., Richardson, A. M., & Neary, D. (2018) · Cortex · doi:10.1016/j.cortex.2017.08.024 · Cited by 140 · see citing works
The anatomy of semantic knowledge: Medial vs. lateral temporal lobe
Levy, D. A., Bayley, P. J., & Squire, L. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401679101 · Cited by 156 · see citing works
<scp>EFNS</scp> task force: the use of neuroimaging in the diagnosis of dementia
Filippi, M., Agosta, F., Barkhof, F., Dubois, B., Fox, N. C., Frisoni, G. B., Jack, C. R., Johannsen, P., Miller, B. L., Nestor, P. J., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03859.x · Cited by 141 · see citing works
Self-citationDuval, C., Desgranges, B., de La Sayette, V., Belliard, S., Eustache, F., & Piolino, P. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.11.019 · Cited by 138 · see citing works
Self-projection and the default network in frontotemporal dementia
Irish, M., Piguet, O., & Hodges, J. R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.11 · Cited by 140 · see citing works
An algorithmic approach to structural imaging in dementia
Harper, L., Barkhof, F., Scheltens, P., Schott, J. M., & Fox, N. C. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306285 · Cited by 137 · see citing works
Self-citationThe more physical inactivity, the more agitation in dementia
Scherder, E. J. A., Bogen, T., Eggermont, L. H. P., Hamers, J. P. H., & Swaab, D. F. (2010) · International Psychogeriatrics · doi:10.1017/s1041610210001493 · Cited by 121 · see citing works
Hippocampal Subfield Volumetry and 3D Surface Mapping in Subjective Cognitive Decline
Perrotin, A., de Flores, R., Lamberton, F., Poisnel, G., La Joie, R., de la Sayette, V., Mézenge, F., Tomadesso, C., Landeau, B., Desgranges, B., et al. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150087 · Cited by 119 · see citing works
Impaired capacity for prospection in the dementias—theoretical and clinical implications
Irish, M., & Piolino, P. (2016) · British Journal of Clinical Psychology · doi:10.1111/bjc.12090 · Cited by 107 · see citing works
Disrupted brain connectome in semantic variant of primary progressive aphasia
Agosta, F., Galantucci, S., Valsasina, P., Canu, E., Meani, A., Marcone, A., Magnani, G., Falini, A., Comi, G., & Filippi, M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.017 · Cited by 94 · see citing works
Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year
Knopman, D. S., Jack, C. R., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a71236 · Cited by 85 · see citing works
Distribution of brain atrophy in behavioral variant frontotemporal dementia
Kril, J. J., Macdonald, V., Patel, S., Png, F., & Halliday, G. M. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.02.003 · Cited by 83 · see citing works
Peet, B. T., Spina, S., Mundada, N., & La Joie, R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01101-x · Cited by 74 · see citing works
Chapleau, M., Aldebert, J., Montembeault, M., & Brambati, S. M. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160382 · Cited by 73 · see citing works
Measuring disease progression in frontotemporal lobar degeneration: A clinical and MRI study
Gordon, E., Rohrer, J. D., Kim, L. G., Omar, R., Rossor, M. N., Fox, N. C., & Warren, J. D. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d1a879 · Cited by 70 · see citing works
Self-citationIrish, M., Landin-Romero, R., Mothakunnel, A., Ramanan, S., Hsieh, S., Hodges, J. R., & Piguet, O. (2018) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.03.014 · Cited by 65 · see citing works
Iaccarino, L., Crespi, C., Della Rosa, P. A., Catricalà, E., Guidi, L., Marcone, A., Tagliavini, F., Magnani, G., Cappa, S. F., & Perani, D. (2015) · PLOS ONE · doi:10.1371/journal.pone.0120197 · Cited by 56 · see citing works
FTD spectrum: Neuroimaging across the FTD spectrum
Whitwell, J. L. (2019) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2019.05.009 · Cited by 53 · see citing works
Self-citationAgosta, F., Ferraro, P. M., Canu, E., Copetti, M., Galantucci, S., Magnani, G., Marcone, A., Valsasina, P., Sodero, A., Comi, G., et al. (2015) · Radiology · doi:10.1148/radiol.15141869 · Cited by 48 · see citing works
‘I remember it as if it were yesterday’: Memory for recent events in patients with semantic dementia
Adlam, A.-L. R., Patterson, K., & Hodges, J. R. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.029 · Cited by 48 · see citing works
McCarthy, R. A., Kopelman, M. D., & Warrington, E. K. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.06.024 · Cited by 37 · see citing works
Watanabe, T., Kimura, H. M., Hirose, S., Wada, H., Imai, Y., Machida, T., Shirouzu, I., Miyashita, Y., & Konishi, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5553-11.2012 · Cited by 28 · see citing works
Using diffusion tensor imaging to detect cortical changes in fronto-temporal dementia subtypes
Torso, M., Bozzali, M., Cercignani, M., Jenkinson, M., & Chance, S. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68118-8 · Cited by 27 · see citing works
Olfactory bulb integrity in frontotemporal dementia and Alzheimer’s disease
Carnemolla, S. E., Kumfor, F., Liang, C. T., Foxe, D., Ahmed, R. M., & Piguet, O. (2022) · Journal of Alzheimer’s Disease · doi:10.3233/jad-220080 · Cited by 16 · see citing works
Grey and white matter brain network changes in frontotemporal dementia subtypes
Nguyen, T., Bertoux, M., O’Callaghan, C., Ahmed, S., Hodges, J., & Hornberger, M. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0141-2 · Cited by 9 · see citing works
- Authors
- Chan, D., Fox, N. C., Scahill, R. I., Crum, W. R., Whitwell, J. L., Leschziner, G., Rossor, A. M., Stevens, J. M., Cipolotti, L., & Rossor, M. N.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Corresponding author
- Fox, Nick C.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-04
- Volume
- 49
- Issue
- 4
- Pages
- 433-442
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2127384340
- Cited by
- 749
- References
- 46
- Citations by year
- 2026: 9 · 2025: 26 · 2024: 32 · 2023: 15 · 2022: 24 · 2021: 29 · 2020: 25 · 2019: 29 · 2018: 21 · 2017: 27 · 2016: 25 · 2015: 41 · 2014: 66 · 2013: 34 · 2012: 29
- FWCI
- 21.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- temporal lobe atrophy, semantic dementia, Alzheimer's disease, hippocampal atrophy, entorhinal cortex, amygdala, fusiform gyrus, inferior temporal gyrus, middle temporal gyrus, anteroposterior gradient, semantic memory, brain volumetry
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Dementia, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Temporal Lobe
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
