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Cited by 78Olfactory and Sensory Function StudiesParkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

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Chemosensory dysfunction in neurodegenerative diseases

Richard L. Doty, C H Hawkes·2019·Handbook of Clinical Neurology
DOI 10.1016/b978-0-444-63855-7.00020-4
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Abstract

A number of neurodegenerative diseases are accompanied by disordered smell function. The degree of dysfunction can vary among different diseases, such that olfactory testing can aid in differentiating, for example, Alzheimer's disease (AD) from major affective disorder and Parkinson's disease (PD) from progressive supranuclear palsy. Unfortunately, altered smell function often goes unrecognized by patients and physicians alike until formal testing is undertaken. Such testing uniquely probes brain regions not commonly examined in physical examinations and can identify, in some cases, patients who are already in the "preclinical" stage of disease. Awareness of this fact is one reason why the Quality Standards Committee of the American Academy of Neurology has designated smell dysfunction as one of the key diagnostic criteria for PD. The same recommendation has been made by the Movement Disorder Society for both the diagnosis of PD and identification of prodromal PD. Similar suggestions are proposed to include olfactory dysfunction as an additional research criterion for the diagnosis of AD. Although taste impairment, i.e., altered sweet, sour, bitter, salty, and umami perception, has also been demonstrated in some disorders, taste has received much less scientific attention than smell. In this review, we assess what is known about the smell and taste disorders of a wide range of neurodegenerative diseases and describe studies seeking to understand their pathologic underpinnings.

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Metadata

Authors
Doty, R. L., & Hawkes, C. H.
Affiliations
  • University of Pennsylvania (US)
  • Blizard Institute (GB)
Corresponding author
Richard L. Doty
ORCID
Venue
Handbook of Clinical Neurology
Publisher
Elsevier
Published
2019
Volume
164
Pages
325-360
ISSN
0072-9752 (ISSN-L)
DOI
10.1016/b978-0-444-63855-7.00020-4
OpenAlex
W2979614869
Cited by
78
References
4
Citations by year
2026: 1 · 2025: 7 · 2024: 15 · 2023: 20 · 2022: 12 · 2021: 13 · 2020: 10
FWCI
8.80
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Handbook of clinical neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
chemosensory dysfunction, olfactory dysfunction, taste disorders, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, prodromal Parkinson's disease, olfactory testing, diagnostic criteria, preclinical disease detection
MeSH terms
Alzheimer Disease, Olfaction Disorders, Humans, Parkinson Disease, Smell, Taste Disorders, Neurodegenerative Diseases

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