Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis
Open accessAbstract
Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. Objective: To study the cross-sectional associations of pulmonary function with structural brain variables. Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Population surveys show that poorer pulmonary function is associated with a decreased brain volume and increased white matter hyperintensity (WMH), and a 1-year increase in the lung biological age increases the brain biological age by 25 days.
“According to population surveys, poorer pulmonary function (PF) is associated with a decreased brain volume and increased white matter hyperintensity (WMH),262 and a 1-year increase in the lung BA increases the brain BA by 25 days.”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [262]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Harrell (2015) · Springer Series in Statistics · doi:10.1007/978-3-319-19425-7 · Cited by 6,878 · see citing works
Quanjer, P. H., Stanojevic, S., Cole, T. J., Baur, X., Hall, G. L., Culver, B. H., Enright, P., Hankinson, J., Ip, M., Zheng, J., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00080312 · Cited by 5,944 · see citing works
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,484 · see citing works
Graham, B. L., Steenbruggen, I., Miller, M. R., Barjaktarevic, I. Z., Cooper, B. G., Hall, G. L., Hallstrand, T. S., Kaminsky, D. A., McCarthy, K., McCormack, M. C., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201908-1590st · Cited by 4,305 · see citing works
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652 · see citing works
Self-citationTHE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 3,491 · see citing works
(1989) · PubMed · Cited by 3,139 · see citing works
Longstreth, W. T., Manolio, T. A., Arnold, A., Burke, G. L., Bryan, N., Jungreis, C. A., Enright, P. L., O'Leary, D., & Fried, L. (1996) · Stroke · doi:10.1161/01.str.27.8.1274 · Cited by 1,464 · see citing works
Self-citationSchwarzer, G., Carpenter, J. R., & Rücker, G. (2015) · Use R! · doi:10.1007/978-3-319-21416-0 · Cited by 1,230 · see citing works
Scahill, R. I., Frost, C. D., Jenkins, R., Whitwell, J. L., Rossor, M. N., & Fox, N. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.7.989 · Cited by 924 · see citing works
Barker, D. J., Godfrey, K. M., Fall, C., Osmond, C., Winter, P. D., & Shaheen, S. O. (1991) · BMJ · doi:10.1136/bmj.303.6804.671 · Cited by 889 · see citing works
Lopez-Garcia, E., Schulze, M. B., Fung, T. T., Meigs, J. B., Rifai, N., Manson, J. E., & Hu, F. B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1029 · Cited by 881 · see citing works
Splansky, G. L., Corey, D., Yang, Q., Atwood, L. D., Cupples, L. A., Benjamin, E. J., D'Agostino, R. B., Fox, C. S., Larson, M. G., Murabito, J. M., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm021 · Cited by 860 · see citing works
Self-citationAssociation of Improved Air Quality with Lung Development in Children
Gauderman, W. J., Urman, R., Avol, E. L., Berhane, K. T., McConnell, R., Rappaport, E. B., Chang, R., Lurmann, F. W., & Gilliland, F. D. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414123 · Cited by 712 · see citing works
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
Harris, T. B., Launer, L. J., Eiriksdottir, G., Kjartansson, O., Jonsson, P. V., Sigurdsson, G., Thorgeirsson, G., Aspelund, T., Garcia, M. E., Cotch, M. F., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwk115 · Cited by 592 · see citing works
Self-citationPrediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification
Davatzikos, C. A., Bhatt, P., Shaw, L. M. J., Batmanghelich, K. N., & Trojanowski, J. Q. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.023 · Cited by 577 · see citing works
Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI
Jack, C. R., Shiung, M. M., Weigand, S. D., O’Brien, P. C., Gunter, J. L., Boeve, B. F., Knopman, D. S., Smith, G. E., Ivnik, R. J., Tangalos, E. G., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000180958.22678.91 · Cited by 492 · see citing works
Self-citationObjectives, design and main findings until 2020 from the Rotterdam Study
Ikram, M. A., Brusselle, G., Ghanbari, M., Goedegebure, A., Ikram, M. K., Kavousi, M., Kieboom, B. C. T., Klaver, C. C. W., de Knegt, R. J., Luik, A. I., et al. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00640-5 · Cited by 450 · see citing works
Self-citationAdam, M., Schikowski, T., Carsin, A., Cai, Y. S., Jacquemin, B., Sanchez, M., Vierkötter, A., Marcon, A., Keidel, D., Sugiri, D., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00130014 · Cited by 383 · see citing works
Novel findings from 2,838 Adult Brains on Sex Differences in Gray Matter Brain Volume
Lotze, M., Domin, M., Gerlach, F. H., Gaser, C., Lueders, E., Schmidt, C. O., & Neumann, N. (2019) · Scientific Reports · doi:10.1038/s41598-018-38239-2 · Cited by 252 · see citing works
Spirometric Criteria for Airway Obstruction
Hansen, J. E., Sun, X., & Wasserman, K. (2007) · CHEST Journal · doi:10.1378/chest.06-1349 · Cited by 239 · see citing works
Cohort Profile Update: The Study of Health in Pomerania (SHIP)
Völzke, H., Schössow, J., Schmidt, C. O., Jürgens, C., Richter, A., Werner, A., Werner, N., Radke, D., Teumer, A., Ittermann, T., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac034 · Cited by 213 · see citing works
Self-citationCOPD and cognitive impairment: the role of hypoxemia and oxygen therapy
Eisner (2010) · International Journal of COPD · doi:10.2147/copd.s10684 · Cited by 185 · see citing works
Peers, C., Dallas, M. L., Boycott, H. E., Scragg, J. L., Pearson, H. A., & Boyle, J. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05026.x · Cited by 166 · see citing works
Insulin resistance and pathological brain ageing
Cholerton, B., Baker, L. D., & Craft, S. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03464.x · Cited by 160 · see citing works
Godfrey, M. S., & Jankowich, M. D. (2015) · CHEST Journal · doi:10.1378/chest.15-1045 · Cited by 152 · see citing works
Vital Capacity as a Predictor of Incident Type 2 Diabetes
Yeh, H., Punjabi, N. M., Wang, N., Pankow, J. S., Duncan, B. B., & Brancati, F. L. (2005) · Diabetes Care · doi:10.2337/diacare.28.6.1472 · Cited by 151 · see citing works
Dodd, J. W., Chung, A. W., van den Broek, M. D., Barrick, T. R., Charlton, R. A., & Jones, P. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0355oc · Cited by 144 · see citing works
Systemic inflammation and lung function in young adults
Hancox, R. J., Poulton, R., Greene, J., Filsell, S., McLachlan, C. R., Rasmussen, F., Taylor, D. R., Williams, M. J. A., Williamson, A., & Sears, M. R. (2007) · Thorax · doi:10.1136/thx.2006.076877 · Cited by 139 · see citing works
Genome-wide association analysis identifies six new loci associated with forced vital capacity
Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3011 · Cited by 138 · see citing works
Self-citationChronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review
Lahousse, L., Tiemeier, H. W., Ikram, M. A., & Brusselle, G. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.07.014 · Cited by 136 · see citing works
Self-citationImpaired Lung Function, Lung Disease, and Risk of Incident Dementia
Lutsey, P. L., Chen, N., Mirabelli, M. C., Lakshminarayan, K., Knopman, D. S., Vossel, K. A., Gottesman, R. F., Mosley, T. H., & Alonso, Á. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1220oc · Cited by 133 · see citing works
Self-citationPathan, S. S., Gottesman, R. F., Mosley, T. H., Knopman, D. S., Sharrett, A. R., & Alonso, Á. (2011) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03340.x · Cited by 116 · see citing works
Self-citationSchünemann, H. J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.5.463 · Cited by 112 · see citing works
Pulmonary Function, Cognitive Impairment and Brain Atrophy in a Middle-Aged Community Sample
Sachdev, P. S., Anstey, K. J., Parslow, R. A., Wen, W., Maller, J. J., Kumar, R., Christensen, H. M., & Jorm, A. F. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000091438 · Cited by 93 · see citing works
Arterial oxygen saturation, COPD, and cerebral small vessel disease
van Dijk, E. J. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.022012 · Cited by 87 · see citing works
Bäckman, H., Lindberg, A., Sovijärvi, A. R. A., Larsson, K., Lundbäck, B., & Rönmark, E. (2015) · BMC Pulmonary Medicine · doi:10.1186/s12890-015-0022-2 · Cited by 86 · see citing works
Jackson, B. M. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh003 · Cited by 82 · see citing works
Bäckman, H., Eriksson, B., Hedman, L., Stridsman, C., Jansson, S., Sovijärvi, A. R. A., Lindberg, A., Rönmark, E., & Lundbäck, B. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.10.005 · Cited by 77 · see citing works
Lower Pulmonary Function and Cerebral Subclinical Abnormalities Detected by MRI
Liao, D., HIGGINS, M. W., Bryan, R. N., Eigenbrodt, M. L., Chambless, L. E., Lamar, V., Burke, G. L., & HEISS, G. M. (1999) · CHEST Journal · doi:10.1378/chest.116.1.150 · Cited by 76 · see citing works
Chhabra, S. K. (1998) · Journal of Asthma · doi:10.3109/02770909809075669 · Cited by 75 · see citing works
Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis
Saad, N. J., Patel, J., Burney, P., & Minelli, C. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201609-746sr · Cited by 74 · see citing works
Primary pulmonary botryomycosis: a bacterial lung infection mimicking lung cancer [Case study]
Ariza‐Prota, M., Pando‐Sandoval, A., Clemente, M. M. G., Jiménez, H., Álvarez-Álvarez, C., & Casán, P. (2012) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.12.0054 · Cited by 68 · see citing works
Mind Diet Adherence and Cognitive Performance in the Framingham Heart Study
van Lent, D. M., O’Donnell, A., Beiser, A., Vasan, R. S., DeCarli, C. S., Scarmeas, N., Wagner, M., Jacques, P. F., Seshadri, S. S., Himali, J. J., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201238 · Cited by 64 · see citing works
Self-citationInflammatory markers and imaging patterns of advanced brain aging in the general population
Janowitz, D., Habes, M., Toledo, J. B., Hannemann, A., Frenzel, S., Terock, J., Davatzikos, C. A., Hoffmann, W. U., & Grabe, H. J. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00058-y · Cited by 37 · see citing works
Self-citationAirflow limitation, lung volumes and systemic inflammation in a general population
Gläser, S., Ittermann, T., Koch, B., Völzke, H., Wallaschofski, H., Nauck, M. A., Warnke, C., Vogelmeier, C. F., Schulz, H., Felix, S. B., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00009811 · Cited by 35 · see citing works
Self-citationSpilling, C. A., Jones, P., Dodd, J. W., & Barrick, T. R. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0435-1 · Cited by 33 · see citing works
Spilling, C. A., Bajaj, M.-P. K., Burrage, D., Ruickbie, S., Thai, N. J., Baker, E. H., Jones, P., Barrick, T. R., & Dodd, J. W. (2019) · International Journal of COPD · doi:10.2147/copd.s213607 · Cited by 33 · see citing works
Ventilatory Capacity and Risk for Dementia
Schaub, R., Münzberg, H., Borchelt, M., Nieczaj, R., Hillen, T., Reischies, F. M., Schlattmann, P., Geiselmann, B., & Steinhagen‐Thiessen, E. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.11.m677 · Cited by 31 · see citing works
Brain structure mediates the association between height and cognitive ability
Vuoksimaa, E., Panizzon, M. S., Franz, C. E., Fennema‐Notestine, C., Hagler, D. J., Lyons, M. J., Dale, A. M., & Kremen, W. S. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1675-4 · Cited by 30 · see citing works
Association of FVC and Total Mortality in US Adults With Metabolic Syndrome and Diabetes
Lee, H. M., Chung, S. J., López, V. A., & Wong, N. D. (2009) · CHEST Journal · doi:10.1378/chest.08-1901 · Cited by 26 · see citing works
Air pollution exposure is associated with restrictive ventilatory patterns
de Jong, K., Vonk, J. M., Zijlema, W. L., Stolk, R. P., van der Plaat, D. A., Hoek, G., Brunekreef, B., Postma, D. S., & Boezen, H. M. (2016) · European Respiratory Journal · doi:10.1183/13993003.00556-2016 · Cited by 25 · see citing works
Correlation between pulmonary function and brain volume in healthy elderly subjects
Taki, Y., Kinomura, S., Ebihara, S., Thyreau, B., Sato, K., Goto, R., Kakizaki, M., Tsuji, I., Kawashima, R., & Fukuda, H. (2013) · Neuroradiology · doi:10.1007/s00234-013-1157-6 · Cited by 22 · see citing works
Global lung function initiative 2012 reference values for spirometry in Asian Americans
Zhang, J., Hu, X., Tian, X., & Xu, K. (2018) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0658-9 · Cited by 16 · see citing works
Kim, Y., Lee, H. J., Son, T. O., Jang, H., Cho, S. H., Kim, S. E., Kim, S. J., Lee, J. S., Kim, J. P., Jung, Y. H., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102140 · Cited by 16 · see citing works
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Systemic determinants of brain health in ageing
Smith, E. E., Biessels, G. J., Gao, V., Gottesman, R. F., Liesz, A., Parikh, N. S., & Iadecola, C. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01016-z · Cited by 54 · see citing works
Self-citationWrzesień, A., Andrzejewski, K., Jampolska, M., & Kaczyńska, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042327 · Cited by 25 · see citing works
Cestelli, L., Gulsvik, A., Johannessen, A., Stavem, K., & Nielsen, R. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107421 · Cited by 19 · see citing works
Grande, G., Li, Y., Trevisan, C., Rizzuto, D., Kalpouzos, G., Ding, M., Laukka, E. J., Bellander, T., Fratiglioni, L., & Qiu, C. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14079 · Cited by 18 · see citing works
Clinical and Imaging Markers of Cardiac Function and Brain Health
Yaqub, A., Bis, J. C., Frenzel, S., Koini, M., Mbangdadji, D., Peloso, G. M., Talluri, R., Alonso, Á., Bahls, M., Bülow, R., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000213421 · Cited by 16 · see citing works
Self-citationDong, B., Yang, Y., Wang, Z., Sun, M., & Wang, Y. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05080-4 · Cited by 15 · see citing works
Fukatsu-Chikumoto, A., Hirano, T., Takahashi, S., Ishida, T., Yasuda, K., Donishi, T., Suga, K., Doi, K., Oishi, K., Ohata, S., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-53933-0 · Cited by 12 · see citing works
Brain structural changes in COPD patients with cognitive impairment
Jia-kai, H., Yun-sheng, T., Xin-yu, H., Shuai, Z., Wang, Z., Ze-hao, C., Yu-feng, M., Yi, L., Zi-ang, Y., Hong-tao, W., et al. (2026) · Journal of Neurology · doi:10.1007/s00415-025-13602-2 · Cited by 11 · see citing works
Lung Function and Brain MRI Outcomes in the Atherosclerosis Risk in Communities Neurocognitive Study
Shrestha, S., Zhu, X., Sullivan, K., Simino, J. M., Lutsey, P. L., Gottesman, R. F., London, S. J., Griswold, M. E., & Mosley, T. H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240162 · Cited by 8 · see citing works
Self-citationEstrella, M. L., Tarraf, W., Kuwayama, S., Gallo, L. C., Salazar, C. R., Stickel, A. M., Mattei, J., Vásquez, P. M., Eldeirawi, K. M., Perreira, K. M., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230796 · Cited by 5 · see citing works
Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons
Murrieta-Álvarez, I., Fernández-Gutiérrez, J. A., Pérez, C. A., León-Peña, A. A., Reyes-Cisneros, O. A., Benítez-Salazar, J. M., Sánchez‐Bonilla, D., Olivares‐Gazca, J. C., Fernández-Lara, D., Pérez‐Padilla, R., et al. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06914-6 · Cited by 5 · see citing works
Zheng, Y., Qiu, P., Luo, H., Chen, R., Wang, X., & Chen, P. (2025) · Aging Clinical and Experimental Research · doi:10.1007/s40520-025-03151-z · Cited by 4 · see citing works
Wang, H.-Q., Feng, Y.-K., Hu, X.-B., Wu, W., Lai, X., Gao, F., & Wang, B. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119798 · Cited by 3 · see citing works
Elmståhl, S., Ellström, K., Månsson, T., Basna, R., Siennicki‐Lantz, A., & Abul‐Kasim, K. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251333793 · Cited by 2 · see citing works
Vivek, S., Crimmins, E. M., Kim, J. K., Faul, J. D., Jacobs, D. R., Guan, W., & Thyagarajan, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-48115-z · Cited by 1 · see citing works
Lung function and the risk of Parkinson’s disease: a population-based cohort study
Liu, J., Wang, S., Zheng, X., Zhang, S., Jiang, Q., Li, C., & Shang, H. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13274-y · Cited by 1 · see citing works
Yeshaw, Y., Madakkatel, I., Mulugeta, A., Lumsden, A. L., & Hyppönen, E. (2025) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70090
Dong, B., Yang, Y., Wang, Z., Sun, M., & Wang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25906494
You, H., Huang, C., Fan, L., Feng, X., Zhang, Y., & Shao, N. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121238
Cui, X., Zhai, W., Wang, Z., Xu, Y., Fan, D., Zhang, Q., & Sun, L. (2026) · Medicine · doi:10.1097/md.0000000000047457
- Authors
- Frenzel, S., Bis, J. C., Gudmundsson, E. F., O’Donnell, A., Simino, J., Yaqub, A., Bartz, T. M., Brusselle, G. G. O., Bülow, R., DeCarli, C. S., Ewert, R., Gharib, S. A., Ghosh, S., Gireud-Goss, M., Gottesman, R. F., Ikram, M. A., Knopman, D. S., Launer, L. J., London, S. J., Longstreth, W. T., Lopez, O. L., Melo van Lent, D., O’Connor, G., Satizabal, C. L., Shrestha, S., Sigurdsson, S., Stubbe, B., Talluri, R., Vasan, R. S., Vernooij, M. W., Völzke, H., Wiggins, K. L., Yu, B., Beiser, A. S., Gudnason, V., Mosley, T., Psaty, B. M., Wolters, F. J., Grabe, H. J., & Seshadri, S.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- University of Washington (US)
- Icelandic Heart Association (IS)
- Boston University (US)
- University of Mississippi Medical Center (US)
- Erasmus MC (NL)
- University of California, Davis (US)
- Glenn Biggs Institute for Alzheimer and Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, SanAntonio, TX, USA
- National Institutes of Health (US)
- Mayo Clinic (US)
- United States Department of Health and Human Services (US)
- Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
- Framingham Heart Study, Framingham, MA, USA
- The University of Texas Health Science Center at Houston (US)
- University of Iceland (IS)
- Corresponding author
- Frenzel, Stefan
- ORCID
- Frenzel, Stefan
- Bis, Joshua C.
- Gudmundsson, Elias F.
- O’Donnell, Adrienne
- Simino, Jeannette
- Yaqub, Amber
- Bartz, Traci M.
- Brusselle, Guy G. O.
- Bülow, Robin
- DeCarli, Charles S.
- Ewert, Ralf
- Gharib, Sina A.
- Ghosh, Saptaparni
- Gottesman, Rebecca F.
- Ikram, M. Arfan
- Knopman, David S.
- Launer, Lenore J.
- London, Stephanie J.
- O’Connor, George
- Shrestha, Srishti
- Sigurdsson, Sigurdur
- Stubbe, Beate
- Talluri, Rajesh
- Vasan, Ramachandran S.
- Vernooij, Meike W.
- Völzke, Henry
- Wiggins, Kerri L.
- Yu, Bing
- Beiser, Alexa S.
- Gudnason, Vilmundur
- Mosley, Thomas
- Psaty, Bruce M.
- Wolters, Frank J.
- Grabe, Hans J.
- Seshadri, Sudha
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2022-11-22
- Volume
- 90
- Issue
- 3
- Pages
- 1073-1083
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC9712227
- OpenAlex
- W4300981025
- Cited by
- 22
- References
- 59
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 9 · 2023: 2
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (publishedVersion, other-oa)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by-nc-sa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Opin vísindi (Opin vísindi) (submittedVersion, other-oa)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Institute on Aging (R01 AG059421, R01AG054076, RF1AG059421, P30AG066546)
- National Heart, Lung, and Blood Institute (R01HL105756)
- National Institute of Neurological Disorders and Stroke (R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Keywords
- lung function, brain volume
- MeSH terms
- Aged, Brain, Cross-Sectional Studies, Forced Expiratory Volume, Humans, Lung, Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
